|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
<i>N</i>-Methyl D-aspartate receptor subtype 2B (NR2B)-containing NMDAR are associated with cognitive dysfunction in schizophrenia.
|
29695955 |
2018 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
GRIN2B variants were genotyped using standard TaqMan procedures in 175 European patients with schizophrenia deemed resistant or intolerant to treatment.
|
26876050 |
2016 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A surprising number of variants have been found in the N-methyl-d-aspartate receptor (NMDAR) gene family, with the GRIN2B gene encoding the GluN2B subunit being implicated in many cases of neurodevelopmental disorders, which are psychiatric conditions originating in childhood and include language, motor, and learning disorders, autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), developmental delay, epilepsy, and schizophrenia.
|
27818011 |
2016 |
|
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Accordingly, we found that upon crack inhalation mice have shown decreased social interaction and working memory deficits analogous to schizophrenia's symptoms, along with increased D2S/D2L expression ratio and decreased expression of NR1, NR2A and NR2B NMDA receptor subunits in the PFC.
|
28314129 |
2017 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Although we did not detect NMDAR2B protein variants, our findings support the possibility that the GRIN2B gene or a locus in linkage disequilibrium with it may confer susceptibility to schizophrenia.
|
11317224 |
2001 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
An association study of the N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) and NR2B subunit gene (GRIN2B) in schizophrenia with universal DNA microarray.
|
15841096 |
2005 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Association analysis of polymorphisms in the N-methyl-D-aspartate (NMDA) receptor subunit 2B (GRIN2B) gene and tardive dyskinesia in schizophrenia.
|
17669510 |
2007 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Association analysis of the genetic variants of the N-methyl D-aspartate receptor subunit 2b (NR2b) and treatment-refractory schizophrenia in the Chinese.
|
12824739 |
2003 |
|
Schizophrenia
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
Changes in GRIN2B promoter methylation may represent an environmental influence contributing to glutamatergic dysfunction in psychosis and relate to lower cognitive performance in subjects with first-episode schizophrenia.
|
30785307 |
2019 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Especially, GluN2B, a subunit of NMDA receptors, associated trafficking complex is altered in the prefrontal cortex of schizophrenia.
|
26421900 |
2015 |
|
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Genetic variation in the NR2B gene predicts reduced levels of the obligatory NR1 subunit, suggesting a novel mechanism by which the NR2B SNP may negatively influence other NMDAR subunit expression and reasoning ability in schizophrenia.
|
23070074 |
2013 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of schizophrenia in Ashkenazi Jews.
|
26198764 |
2015 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
In a recent weighted burden analysis of exome-sequenced schizophrenia cases and controls, we noted modest statistical evidence for an enrichment of rare, functional variants in FYN, GRIN1, and GRIN2B in schizophrenia cases.
|
30664045 |
2019 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
In the present study, we performed western blot analysis to determine whether protein levels of NMDA receptor subunits (NR1, NR2A, NR2B) and associated PSD proteins (NF-L, PSD95, SAP102) are altered in schizophrenia.
|
16762023 |
2006 |
|
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In the present work, we investigated whether expression of this NR2B-associated trafficking complex might be abnormal in schizophrenia.
|
20347576 |
2010 |
|
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In the present work, we observed increased expression of NMDA NR2B subunit transcripts, and decreased expression of all three associated postsynaptic density protein transcripts in schizophrenia.
|
15054476 |
2004 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this study, we investigated whether single nucleotide polymorphisms (SNPs) in GRIN2B were associated with schizophrenia.
|
27453061 |
2016 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this study, we performed a case-control study to identify polymorphisms of the GRIN2B gene that may confer susceptibility to SZ in the Han Chinese population.
|
26020650 |
2015 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
It has also been demonstrated that the level of an ionotropic N-methyl-d-aspartate 2B subunit (GRIN2B) of the glutamate receptor tends to increase after subchronic administration of clozapine, suggesting that GRIN2B may play an active role in the pathogenesis of schizophrenia and the function of clozapine medication.
|
11807413 |
2001 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
It has also been demonstrated that the level of an ionotropic N-methyl-d-aspartate 2B subunit (GRIN2B) of the glutamate receptor tends to increase after subchronic administration of clozapine, suggesting that GRIN2B may play an active role in the pathogenesis of schizophrenia and the function of clozapine medication.
|
11807413 |
2001 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
It is necessary to explain the inconsistency of these results and to clarify the contribution of the GRIN2B gene to schizophrenia.
|
17224684 |
2007 |
|
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
One possible source of compromised glutamatergic function in SZ is decreased surface expression of GluN2B-containing NMDARs.
|
22781170 |
2012 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
CTD_human |
Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.
|
18583979 |
2008 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The findings provided no evidence of an association between schizophrenia and the 2664C/T polymorphism of the NR2B subunit gene.
|
10910800 |
2000 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
LHGDN |
The genetic findings suggest a role for GRIN2B in schizophrenia and bipolar disorder.
|
16549338 |
2006 |