Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease BEFREE It is necessary to explain the inconsistency of these results and to clarify the contribution of the GRIN2B gene to schizophrenia. 17224684 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease BEFREE Association analysis of polymorphisms in the N-methyl-D-aspartate (NMDA) receptor subunit 2B (GRIN2B) gene and tardive dyskinesia in schizophrenia. 17669510 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease LHGDN The genetic findings suggest a role for GRIN2B in schizophrenia and bipolar disorder. 16549338 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease BEFREE In the present study, we performed western blot analysis to determine whether protein levels of NMDA receptor subunits (NR1, NR2A, NR2B) and associated PSD proteins (NF-L, PSD95, SAP102) are altered in schizophrenia. 16762023 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease BEFREE The genetic findings suggest a role for GRIN2B in schizophrenia and bipolar disorder. 16549338 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease LHGDN These findings suggest that the combined effects of the polymorphisms in the GRIN1 and GRIN2B genes might be involved in the etiology of schizophrenia.European Journal of Human Genetics (2005) 13, 807-814. doi:10.1038/sj.ejhg.5201418 Published online 20 April 2005. 15841096 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease BEFREE An association study of the N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) and NR2B subunit gene (GRIN2B) in schizophrenia with universal DNA microarray. 15841096 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease BEFREE These results suggest that GRIN2B variations might be linked with susceptibility to schizophrenia. 15211626 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease LHGDN These results suggest that GRIN2B variations might be linked with susceptibility to schizophrenia. 15211626 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 AlteredExpression disease BEFREE In the present work, we observed increased expression of NMDA NR2B subunit transcripts, and decreased expression of all three associated postsynaptic density protein transcripts in schizophrenia. 15054476 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease BEFREE Association analysis of the genetic variants of the N-methyl D-aspartate receptor subunit 2b (NR2b) and treatment-refractory schizophrenia in the Chinese. 12824739 2003
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease LHGDN These findings suggest that the T-200G variant causes dysfunction of NMDA receptors consisting of the NR2B subunit and may be involved in the development of schizophrenia. 12476325 2002
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease BEFREE These findings suggest that the T-200G variant causes dysfunction of NMDA receptors consisting of the NR2B subunit and may be involved in the development of schizophrenia. 12476325 2002
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease LHGDN It has also been demonstrated that the level of an ionotropic N-methyl-d-aspartate 2B subunit (GRIN2B) of the glutamate receptor tends to increase after subchronic administration of clozapine, suggesting that GRIN2B may play an active role in the pathogenesis of schizophrenia and the function of clozapine medication. 11807413 2001
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease BEFREE It has also been demonstrated that the level of an ionotropic N-methyl-d-aspartate 2B subunit (GRIN2B) of the glutamate receptor tends to increase after subchronic administration of clozapine, suggesting that GRIN2B may play an active role in the pathogenesis of schizophrenia and the function of clozapine medication. 11807413 2001
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease BEFREE Although we did not detect NMDAR2B protein variants, our findings support the possibility that the GRIN2B gene or a locus in linkage disequilibrium with it may confer susceptibility to schizophrenia. 11317224 2001
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease BEFREE The findings provided no evidence of an association between schizophrenia and the 2664C/T polymorphism of the NR2B subunit gene. 10910800 2000