Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 AlteredExpression disease BEFREE Magnesium and ketamine have a common mechanism of action in the treatment of depression: an increase in GluN2B (NMDAR subunit) expression is related to the administration of both of the agents, as well as inhibition of phosphorylation of eEF2 (eukaryotic elongation factor 2) in cell culture and increase of the expression of BDNF in the hippocampus. 31488789 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 AlteredExpression disease BEFREE Ketamine can improve expression of NR2B, LTP induction and NMDA receptor-mediated EPSCs in the hippocampus of depression-like mice, which might be part of the reason why ketamine can alleviate the memory dysfunction induced by depression. 30356718 2018
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 Biomarker disease BEFREE The effects common to ketamine and NR2B-selective compounds were localized to the same brain regions as those reported in depression, but in the opposite direction. 29305627 2018
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 Biomarker disease BEFREE The interaction of death-associated protein kinase <b>1</b> (DAPK1) with the 2B subunit (GluN2B) C-terminus of N-methyl-D-aspartate receptor (NMDAR) plays a critical role in the pathophysiology of depression and is considered a potential target for the structure-based discovery of new antidepressants. 30463177 2018
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 AlteredExpression disease BEFREE Downregulation of Egr-1 Expression Level via GluN2B Underlies the Antidepressant Effects of Ketamine in a Chronic Unpredictable Stress Animal Model of Depression. 29294341 2018
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 AlteredExpression disease BEFREE Collectively, these results suggest that CCL2/CCR2 signaling in the NAc shell is important in mediating neuropathic pain and depression via regulating NR2B-mediated NMDAR function in D1R- and D2R-containing neurons following peripheral nerve injury. 29993042 2018
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 Biomarker disease BEFREE Altogether, our findings suggest that the DAPK1 interaction with the NMDAR GluN2B subunit acts as a critical component in the pathophysiology of depression and is a potential target for new antidepressant treatments. 28439098 2018
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 AlteredExpression disease BEFREE In addition, decreased GR nuclear translocation with normal mechanical nociception and hypoalgesia of thermal nociception were observed in OB-Sham rats.Intrathecal injection (i.t.) of GR agonist dexamethasone (Dex; 4 μg/rat/day for 1 week) eliminated the attenuating effect of depression on nociceptive hypersensitivity in OB-SNL rats and aggravated neuropathic pain in NOB-SNL rats, which was associated with the up-regulation of brain-derived neurotrophic factor (BDNF), TrkB and NR2B expression in the spinal dorsal horn. 28579944 2017
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 Biomarker disease BEFREE Negative regulation of DAPK1/GluN2B binding by Ca<sup>2+</sup>/CaM results in synaptic DAPK1 removal during LTP but retention during LTD. A pharmacogenetic approach showed that suppression of CaMKII/GluN2B binding is a DAPK1 function required for LTD. 28614711 2017
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 Biomarker disease BEFREE Here, using the chronic mild stress (CMS) paradigm of depression, we found that, independently from the anhedonic phenotype, CMS rats showed a deficit in the novel object recognition (NOR) test, which is associated with an inability to phosphorylate GluN2B subunit on Ser1303 and to activate the mTOR pathway. 28094500 2017
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 Biomarker disease PSYGENET Our study provides strong evidence that Gent inhibits reserpine-induced pain/depression dyad by downregulating GluN2B receptors in the amygdala. 24584520 2014
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 Biomarker disease PSYGENET Indeed, we observed a significant reduction of NMDA-induced field excitatory postsynaptic potential depression in the hippocampus of Tau mice together with a reduced phosphorylation of NR2B at the Y1472, known to be critical for NMDAR function. 23082852 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 PosttranslationalModification disease BEFREE Indeed, we observed a significant reduction of NMDA-induced field excitatory postsynaptic potential depression in the hippocampus of Tau mice together with a reduced phosphorylation of NR2B at the Y1472, known to be critical for NMDAR function. 23082852 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 Biomarker disease PSYGENET In addition, we demonstrate that while stress increased NMDA NR2B-mediated synaptic transmission, known to be implicated in depression, Reelin overexpression significantly reduced it. 21814183 2011
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 Biomarker disease PSYGENET Loss of GluN2B-containing NMDA receptors in CA1 hippocampus and cortex impairs long-term depression, reduces dendritic spine density, and disrupts learning. 20357110 2010
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 Biomarker disease PSYGENET Genetic enhancement of memory and long-term potentiation but not CA1 long-term depression in NR2B transgenic rats. 19838302 2009