Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.560 Biomarker phenotype BEFREE This study investigated the role of SAP102 in the formation of hyperalgesia in rats with CIBP SAP102 is present in spinal dorsal horn neurons, but not in astrocytes or microglia.NMDAR-NR2B is localized with neurons. 31682872 2020
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.560 Biomarker phenotype BEFREE Then, we intrathecally injected MK-801 (an NMDAR inhibitor) and ifenprodil (a selective NR2B subunit antagonist) and observed that the two types of inhibitors not only alleviated masseter hyperalgesia but also significantly inhibited the phosphorylation of JNK in the Vc after restraint stress; this indicates that the effect of NMDAR antagonists may influence the activation of astrocytic JNK. 31798413 2019
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.560 Biomarker phenotype BEFREE Moreover, pretreatment with AMD3100 reduced hyperalgesia and NR2B-containing NMDAR phosphorylation. 30120960 2019
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.560 Biomarker phenotype BEFREE GluN2B/CaMKII mediates CFA-induced hyperalgesia via HDAC4-modified spinal COX2 transcription. 29614314 2018
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.560 Biomarker phenotype BEFREE Downregulation of the spinal NMDA receptor NR2B subunit during electro-acupuncture relief of chronic visceral hyperalgesia. 27221284 2017
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.560 Biomarker phenotype BEFREE GluN2B antagonist also blocked CXCL13, and IL-17 directly induced hyperalgesia. 28359934 2017
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.560 Therapeutic phenotype RGD A polyamine-deficient diet prevents oxaliplatin-induced acute cold and mechanical hypersensitivity in rats. 24204988 2013
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.560 Biomarker phenotype CTD_human This study provides direct evidence that tyrosine phosphorylation of the NR2B at Tyr1472 in spinal dosal horn contributes to postoperative hyperalgesia induced by remifentanil and supports the potential therapeutic value of ketamine for improving postoperative hyperalgesia induced by remifentanil. 20042082 2009