Disease: Memory impairment ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.100 Biomarker phenotype BEFREE Therefore, we also investigated the dynamic of other protein markers involved in cognition and memory impairment such as metabotropic glutamate receptor 5 (mGluR5), ionotropic NMDA receptor (NMDAR2B), prion protein (PrPc) and amyloid precursor protein (APP), whose activity depends on membrane lipid organization. 31068782 2019
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.100 Biomarker phenotype BEFREE AM281, a CB1 receptor antagonist, reversed the TBI-reduced NMDA receptor subunits NR2B in the hippocampus and ameliorate the spatial learning and memory impairment at 7 d post-TBI, suggesting CB1 receptor is involved in the TBI-induced hippocampal-dependent spatial learning and memory impairment. 30576711 2019
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.100 Biomarker phenotype BEFREE Interestingly, pharmacological blockade of GluN2B with the selective antagonist Ro25 6981 was less effective to reduce synaptic plasticity in ELS mice, and was also ineffective to impair memory retrieval in ELS mice. 30641077 2019
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.100 Biomarker phenotype BEFREE Downregulation of hippocampal NR2A subunit was more evident than NR2B in pristane and pristane+LPS at 7 and 12 weeks of treatment and it is related to learning and memory disturbance assayed by Barnes maze. 31498792 2019
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.100 AlteredExpression phenotype BEFREE We found that the activation of GABA<sub>A</sub>Rs (diazepam) and the inactivation of GluN2B-NMDARs (Ro25-6981) or 5-HT<sub>1A</sub>R ((S)-WAY100135) resulted in memory impairment. 31071338 2019
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.100 AlteredExpression phenotype BEFREE The results demonstrated that propofol exposure caused learning and memory deficits and decreased KIF17 and M‑NR2B protein levels in the hippocampus; however, no but changes in the expression of T‑NR2B were observed. 29393422 2018
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.100 Biomarker phenotype BEFREE Collectively, these results show that H<sub>2</sub>S can reverse aging-associated amygdalar synaptic plasticity and fear memory deficits by restoring the function of GluN2B-containing NMDARs, suggesting that supplement of H<sub>2</sub>S might be a therapeutic approach for aging-related cognitive disorders. 29930496 2018
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.100 Biomarker phenotype BEFREE These molecular, cellular and behavioral alterations induced by EphB2 inactivation were reversed by NR2B antagonist Ro25-6981, suggesting that EphB2 functions to prevent the progression of depression-like behavior and memory impairment by downregulating NR2B. 30131699 2018
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.100 GeneticVariation phenotype BEFREE These results suggested that propofol exposure downregulates NR2B membrane translocation and causes spatial memory deficits, with a mediated increased NR2B protein expression and phosphorylation at Ser1303/1480 residues in the hippocampus of neonatal mice. 28729940 2017
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.100 AlteredExpression phenotype BEFREE Accordingly, we found that upon crack inhalation mice have shown decreased social interaction and working memory deficits analogous to schizophrenia's symptoms, along with increased D2S/D2L expression ratio and decreased expression of NR1, NR2A and NR2B NMDA receptor subunits in the PFC. 28314129 2017
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.100 AlteredExpression phenotype BEFREE Results showed that hypertonic saline effectively alleviated spatial learning and memory deficit, enhanced synaptic plasticity of CA3-CA1 hippocampal synapses, upregulated N-methyl-d-aspartate receptor subunit 2B (NR2B) and postsynaptic density protein 95 (PSD-95) surface expressions, reduced oxidative stress and increased Nissl bodies in 2VO model rats. 28934194 2017
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.100 Biomarker phenotype BEFREE Chronic GluN2B antagonism disrupts behavior in wild-type mice without protecting against synapse loss or memory impairment in Alzheimer's disease mouse models. 24920631 2014
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.100 Biomarker phenotype BEFREE Accumulating evidence suggests that elevated brain magnesium levels, via dietary supplementation, can boost NR2B in the brain, consequently reversing memory deficits and enhancing cognitive abilities. 25152202 2014
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.100 AlteredExpression phenotype BEFREE TTBK1-Tg mice show significant age-dependent memory impairment as determined by radial arm water maze test, which is associated with enhancement of tau and neurofilament phosphorylation, increased levels of p25 and p35, both activators of cyclin-dependent protein kinase 5 (CDK5), enhanced calpain I activity, and reduced levels of hippocampal NMDA receptor types 2B (NR2B) and D. Enhanced CDK5/p35 complex formation is strongly correlated with dissociation of F-actin from p35, suggesting the inhibitory mechanism of CDK5/p35 complex formation by F-actin. 19118186 2008