Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0234251
Disease: Inflammatory pain
Inflammatory pain
0.050 Biomarker phenotype BEFREE Here, we show that KCC2-dependent disinhibition is coupled to increased GluN2B-mediated synaptic NMDAR responses in a rodent model of inflammatory pain, with an associated downregulation of the tyrosine phosphatase STEP61. 31135041 2019
CUI: C0234251
Disease: Inflammatory pain
Inflammatory pain
0.050 Biomarker phenotype BEFREE This study shows that pre-emptive administration of propofol produces preventive analgesic effects on inflammatory pain through regulating neuronal GluN2B-containing NMDA receptor and ERK1/2 pathway in the spinal dorsal horn. 28969472 2018
CUI: C0234251
Disease: Inflammatory pain
Inflammatory pain
0.050 Biomarker phenotype BEFREE These results demonstrated that WSLP can efficiently deliver siRNA targeting NR2B to PC12 cells and relieve pain in rats with chronic inflammatory pain. 29623145 2018
CUI: C0234251
Disease: Inflammatory pain
Inflammatory pain
0.050 AlteredExpression phenotype BEFREE Our results reveal that BDNF activates mTOR to up-regulate NR2B expression, which is required for inflammatory pain-related aversion in the rACC of rats. 29353374 2018
CUI: C0234251
Disease: Inflammatory pain
Inflammatory pain
0.050 Biomarker phenotype BEFREE Loss of Arrb2 also results in prolongation of inflammatory pain and neuropathic pain and enhancement of GluN2B-mediated NMDA currents in spinal lamina IIo not lamina I neurons. 27538456 2016