Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0349204
Disease: Nonorganic psychosis
Nonorganic psychosis
0.030 AlteredExpression disease BEFREE Using mature miRNA profiling and quantitative real-time PCR (qRT-PCR) in the orbitofrontal cortex (OFC) of SCZ (N = 29; 20 male and 9 female), BD (N = 26; 12 male and 14 female), and unaffected control (N = 25; 21 male and 4 female) subjects, we uncovered that miR-223, an exosome-secreted miRNA that targets glutamate receptors, was increased at the mature miRNA level in the OFC of SCZ and BD patients with positive history of psychosis at the time of death and was inversely associated with deficits in the expression of its targets glutamate ionotropic receptor NMDA-type subunit 2B (GRIN2B) and glutamate ionotropic receptor AMPA-type subunit 2 (GRIA2). 31775160 2020
CUI: C0349204
Disease: Nonorganic psychosis
Nonorganic psychosis
0.030 PosttranslationalModification disease BEFREE Changes in GRIN2B promoter methylation may represent an environmental influence contributing to glutamatergic dysfunction in psychosis and relate to lower cognitive performance in subjects with first-episode schizophrenia. 30785307 2019
CUI: C0349204
Disease: Nonorganic psychosis
Nonorganic psychosis
0.030 Biomarker disease BEFREE We interpret these observations to implicate a reduction in the influence of a ubiquitous gene repressor, repressor element-1 silencing transcription factor (REST) in psychosis; REST is involved in the age-related maturation of the NMDA receptor from GluN2B- to GluN2A-containing NMDA receptors through epigenetic remodeling. 26211447 2015