Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Glucocorticoid receptor (GR)-α phosphorylated at serine 226 was increased in cells from severe asthma, and the MUC1-CT/GRα complex was downregulated in severe asthma cells.
|
29978485 |
2019 |
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Maternal asthma increases the risk of adverse pregnancy outcomes and may affect fetal growth and placental function by differential effects on the expression of glucocorticoid receptor (GR) isoforms, leading to altered glucocorticoid signalling.
|
31477204 |
2019 |
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Compared with PBMCs from patients with easy-to-control asthma, PBMCs from those with difficult-to-control asthma had significantly lower glucocorticoid receptor α levels at V0 (P = .05).
|
30059697 |
2019 |
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Chronic stress has also been shown to result in biological changes such as expression of immunologic genes, changes in expression of the beta-adrenergic (B2AR) and the glucocorticoid receptor (GR-α) genes, cytokine regulation, and alterations in the hypothalamic pituitary axis and cortisol levels which all may affect asthma pathophysiology and therapeutic response among patients exposed to chronic stress.
|
31079340 |
2019 |
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
AZD7594 is a non-steroidal, selective, glucocorticoid receptor modulator (SGRM), currently in development for the treatment of asthma and chronic obstructive pulmonary disease.
|
31814707 |
2019 |
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Glucocorticoids act on the glucocorticoid receptor (GR; NR3C1) to resolve inflammation and, as inhaled corticosteroids (ICS), are the cornerstone of treatment for asthma.
|
30704470 |
2019 |
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Impaired GRα nuclear translocation and inhibited p-p65 expression might contribute to glucocorticoid resistance caused by MUC1 deficiency in TNF-α-induced necroptosis in 16HBE cells, and should be considered as a potential target for the development of novel therapeutics for asthma.
|
30738043 |
2019 |
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In a sample of 104 youth with asthma (10-17 years) and their primary caregiver, we assessed SES via caregiver report, emotional expression by youth and parents in the home over four days using the electronically activated recorder (EAR), and NR3C1 expression via blood collected from youth.
|
29529520 |
2018 |
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
P values of less than 0.05 were considered to represent statistically significant associations between glucocorticoid receptor gene polymorphisms and asthma.
|
29729712 |
2018 |
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
GLCCI1 deficiency in asthmatic mice inhibits the activation of GR and MKP-1 and leads to more obvious phosphorylation of p38 MAPK, leading to a decremental sensitivity to GCs.
|
30511684 |
2018 |
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Short-term exposure to A. fumigatus could down-regulate the expression of GCR, aggravate airway hyper-responsiveness and increase the level of TLR2 in rats with asthma.
|
28696809 |
2018 |
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to verify glucocorticoid receptor glcococorticoid receptor (GR) nuclear translocation in CD4 T cells treated with fluticasone furoate (FF), vilanterol (V) and FF/V combination in severe asthmatic patients compare to patients with moderate asthma and healthy controls using Immunocytochemistry (ICC).
|
29512364 |
2018 |
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
AZD5423 is a non-steroidal glucocorticoid receptor modulator, with low aqueous solubility, developed for treatment of asthma and COPD.
|
28281196 |
2017 |
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Novel small molecule drugs, such as CRTH2 receptor antagonists, PDE<sub>4</sub> inhibitors, protein kinase inhibitors and nonsteroidal glucocorticoid receptor agonists and 'off-label' use of licensed drugs, such as macrolides and statins are under investigation for asthma, although their effectiveness in clinical practice is not established.
|
28099820 |
2017 |
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
However, interactions between residential greenspace and difficult family relationships were found for asthma control (<i>P</i> = .02), asthma functional limitations (<i>P</i> = .04), airway inflammation (<i>P</i> = .007), and the abundance of glucocorticoid receptor in T-helper cells (<i>P</i> = .05).
|
28280210 |
2017 |
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
A relationship between single nucleotide polymorphism in the glucocorticoid receptor (GCR) gene promoter (Bcl I polymorphism), development of asthma and sensitivity to glucocorticoids has been hypothesised.
|
25982579 |
2016 |
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Homozygosity for the G allele at rs41423247 of the glucocorticosteroid receptor (NR3C1) gene is associated with a higher improvement in FEV1 at 4 h in children with moderate-to-severe asthma exacerbation treated with high-dose ICS.
|
27003716 |
2016 |
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The aim of the present study was to identify polymorphic forms of the nuclear receptor subfamily 3, group C, member 1 (NR3C1) and transforming growth factor β1 (TGF-β1) genes and evaluate their impact on the expression levels of interleukin (IL)-5 and IL‑15 in asthma.
|
27081784 |
2016 |
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, SNPs in NR3C1 were not significantly associated with asthma in patients from the Henan Province.
|
27323143 |
2016 |
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Histamine H1 receptor (H1R) antagonists and glucocorticoid receptor (GR) agonists are used to treat inflammatory conditions such as allergic rhinitis, atopic dermatitis and asthma.
|
26635083 |
2015 |
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
We examined whether the bacterial product lipopolysaccharide (LPS) reduces glucocorticoid receptor (GR) function in control nasal mucosa (NM) fibroblasts and in nasal polyp (NP) fibroblasts from patients with CRSwNP and asthma.
|
25943109 |
2015 |
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Gene network modeling revealed decreased glucocorticoid receptor signaling and increased activity of the mitogen-activated protein kinase and Jun kinase cascades in patients with SA.
|
25863981 |
2015 |
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
There was no significant difference between the I559N and V729I GR variants on comparing SR asthma patients with SS asthma patients or CTRs.
|
25815773 |
2015 |
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
GCs after binding to the glucocorticoid receptor (GR) form the complex (transcription factor), which acts on promoter and regulatory parts of genes enhancing the expression of anti-inflammatory proteins and decreasing the proinflammatory protein synthesis, including numerous cytokines mediating inflammation in the course of asthma.
|
25649164 |
2015 |
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
DEX-stimulated recruitment of GR and histone H4 acetylation at the glucocorticoid response element 4.6 kbp upstream of the MKP-1 gene were significantly lower in monocytes from patients with SR asthma compared with those from patients with SS asthma.
|
24418482 |
2014 |