Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Pathway analysis showed an enrichment of the glucocorticoid receptor (GR) pathway with the genes MED1, HSPA1L, GTF2A1 and TAF15, which might underlie the previously reported role of stress response in the risk for BD in vulnerable populations.
|
28291257 |
2017 |
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Fifty-nine depressed individuals with major depressive disorder (n=33) or bipolar disorder (n=26), and 32 healthy individuals were genotyped for the glucocorticoid receptor BclI G/C polymorphism, and underwent functional magnetic resonance imaging during a monetary reward task.
|
26349556 |
2016 |
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Hypothalamic-pituitary-adrenal axis dysfunction and illness progression in bipolar disorder.
|
25522387 |
2014 |
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
The higher interaction between GR and HSP70 and the disturbances in the relations among heat shock response parameters and GR as observed in our BD patients may provide novel insights into the contribution of these factors in BD aetiopathogenesis.
|
23938235 |
2013 |
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Molecular abnormalities within the glucocorticoid receptor (GR) stress signaling pathway may confer, or reflect, susceptibility to stress in schizophrenia and bipolar disorder, but the extent of such abnormalities in the brain is not known.
|
24345775 |
2013 |
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Molecular abnormalities within the glucocorticoid receptor (GR) stress signaling pathway may confer, or reflect, susceptibility to stress in schizophrenia and bipolar disorder, but the extent of such abnormalities in the brain is not known.
|
24345775 |
2013 |
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
The aim of the study was to investigate the possible association between polymorphisms of HPA axis genes-CRHR1 (corticotrophin-releasing hormone receptor), NR3C1 (glucocorticoid receptor) and AVPR1B (arginine vasopressin receptor) and dimensions of bipolar disorder assessed by OPCRIT.
|
24012103 |
2013 |
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
No association between polymorphisms and haplotypes of the AVPR1b, CRHR1 and NR3C1 genes and depression with melancholic features in the course of bipolar disorder.
|
23068076 |
2013 |
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
No association between polymorphisms and haplotypes of the AVPR1b, CRHR1 and NR3C1 genes and depression with melancholic features in the course of bipolar disorder.
|
23068076 |
2013 |
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The higher interaction between GR and HSP70 and the disturbances in the relations among heat shock response parameters and GR as observed in our BD patients may provide novel insights into the contribution of these factors in BD aetiopathogenesis.
|
23938235 |
2013 |
Bipolar Disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Glucocorticoid receptor mRNA and protein isoform alterations in the orbitofrontal cortex in schizophrenia and bipolar disorder.
|
22812453 |
2012 |
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Evidence for the involvement of the glucocorticoid receptor gene in bipolar disorder in an isolated northern Swedish population.
|
22085474 |
2012 |
Bipolar Disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
GR-1B mRNA was decreased in schizophrenia cases relative to controls (20.2%, p<0.05), while GR-1C mRNA was decreased in both schizophrenia and bipolar disorder cases relative to controls (16.1% and 17.2% respectively, both p<0.005).
|
22427805 |
2012 |
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Glucocorticoid receptor polymorphism is associated with major depression and predominance of depression in the course of bipolar disorder.
|
21764460 |
2011 |
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of the GR-gene are factors which influence some clinical manifestations of BD, with respect to seasonal pattern of (hypo)mania and age of onset.
|
21531081 |
2011 |
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
This finding was replicated in a second cohort of 35 schizophrenia cases, 34 bipolar disorder cases, and 35 controls, in which both schizophrenia and bipolar disorder diagnoses were significant predictors of putative GRα-D1 abundance (p<0.05 and p=0.005, respectively).
|
21881570 |
2011 |
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of our study is to evaluate associations between GR gene polymorphisms and bipolar disorder (BD).
|
19133972 |
2009 |
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In this overview, currently known clinically relevant GR and MR polymorphisms are discussed in relation to mood disorders (both unipolar depression and bipolar disorder) and cognitive function.
|
19906241 |
2009 |
Bipolar Disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Additionally, these studies suggest that regulation of GR-mediated plasticity may play a role in the treatment of bipolar disorder and raise the possibility that agents affecting BAG-1 more directly may represent novel therapies for this devastating illness.
|
15872096 |
2005 |
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
CTD_human |
Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology Consortium.
|
14708030 |
2004 |
Bipolar Disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Compared with control subjects, GR mRNA expression was reduced in the basolateral/lateral nuclei in schizophrenia and bipolar disorder.
|
15576061 |
2004 |
Bipolar Disorder
|
0.600 |
AlteredExpression
|
disease |
LHGDN |
Compared with control subjects, GR mRNA expression was reduced in the basolateral/lateral nuclei in schizophrenia and bipolar disorder.
|
15576061 |
2004 |