Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Differential effects of DRN GR deletion in female mice may provide insight into the greater incidence of depression and specific depression symptoms in women.
|
31846734 |
2020 |
Mental Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Time-group interaction effects were found for several impulsivity scores, SCL-90R Global Severity Index, Paranoid Thoughts, and Depression subscales as well as for NR3C1 expression.
|
31812111 |
2020 |
Mental Depression
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
Poisson regression with robust variance adjusted by gender, tobacco use, self-perceived stress, leisure activity, suicidal ideation, low cortisol levels and NR3C1 DNA methylation was performed and predicted risk factors for depression.
|
31731185 |
2020 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
The mineralocorticoid receptor (MR)/glucocorticoid receptor balance plays an important role in the pathophysiology of anxiety and depression.
|
30852427 |
2019 |
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Pain and depressive-like behavior were measured over 14 days and brain-derived neurotrophic factor (BDNF; a factor involved in nociception and depression) and glucocorticoid receptor (GR; a stress-related receptor) expression were measured on day 14.
|
31815911 |
2019 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Glucocorticoid receptor dysfunction orchestrates inflammasome effects on chronic obstructive pulmonary disease-induced depression: A potential mechanism underlying the cross talk between lung and brain.
|
30738183 |
2019 |
Mental Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Considering possible confounding effects of alcohol and/or depression, we conclude that chronic cocaine use is associated with lower NR3C1 gene expression suggesting possible direct effects of the drug on the biological adaptation of stress-related genes.
|
29761890 |
2019 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Studies investigating Glucocorticoid Receptor (GR/NR3C1) in the brain have primarily focused on the forebrain, however in recent years, the hindbrain has become a region of interest for research into the development of anxiety and depression, though the role of GR signalling in the hindbrain remains poorly characterised.
|
30824750 |
2019 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Mothers with depression also had lower NR3C1 than other mothers (p < 0.003) but did not differ in OXTR.
|
29580902 |
2019 |
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Methylation of the glucocorticoid receptor gene associated with depression in patients with acute coronary syndrome.
|
30408722 |
2019 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
We argue that better understanding the long-term effects of developmental stressors on PFC trkB, GR, and related factors may yield insights into risk for chronic, remitting depression and related neuropsychiatric illnesses.
|
30477984 |
2018 |
Mental Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
APPL2 Tg mice displayed higher GR activity and less capacity of neurogenesis at olfactory system with less olfactory sensitivity than WT mice, indicating that APPL2 could be a potential therapeutic target for depression and olfactory deficits.
|
29675572 |
2018 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
The glucocorticoid receptor is dysfunctional in depression, and it is a direct target of miR-124.
|
29484897 |
2018 |
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis demonstrates that the NR3C1 rs41423247 homozygous mutation may be a risk factor for depression.
|
30278546 |
2018 |
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that hypermethylation at the NR3C1 exon 1F may occur in depression.
|
29793048 |
2018 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Regulators of glucocorticoid receptor function in an animal model of depression and obesity.
|
29524264 |
2018 |
Mental Depression
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
Additionally, a higher NR3C1 methylation level at CpG 2 was associated with depression incidence 2 years later in this population.
|
29432878 |
2018 |
Mental Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In addition, six glucocorticoid receptor pathway genes (Slc22a5, Aqp1, Stat5a, Ampd3, Plekhf1, and Cyb561) were upregulated in GF mice, and of these only two (Stat5a and Ampd3) were upregulated in LPS-treated mice, whereas the shared gene, Stat5a, was downregulated in "depression microbiota" recipient mice.
|
30194287 |
2018 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
The noradrenergic system and GR pathway in the locus coeruleus may be involved in the formation of depression concomitant with sleep disturbances.
|
29894769 |
2018 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Combining both models resulted in 22 new and confirmed HSP90-independent NR3C1 inhibitors, providing two scaffolds (i.e., pyrimidine and pyrazolo-pyrimidine), which could potentially be of interest in the treatment of depression (i.e., inhibiting the glucocorticoid receptor (i.e., NR3C1), while leaving its chaperone, HSP90, unaffected).
|
29658791 |
2018 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
The results do not support the hypothesis that GR dysregulation is aetiopathogenic in CFS and suggest that current and future endocrine cross-sectional studies in CFS may be vulnerable to the confounding influence of childhood trauma which is likely increased by comorbid depression.
|
29983634 |
2018 |
Mental Depression
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
The glucocorticoid receptor gene (NR3C1) displayed different methylation patterns in chronic stress and depression.
|
27998510 |
2017 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
The sex-dependent role of the glucocorticoid receptor in depression: variations in the NR3C1 gene are associated with major depressive disorder in women but not in men.
|
27549215 |
2017 |
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In the context of environmental stress, a functional variant in the glucocorticoid receptor co-chaperone FKBP5 gene has been repeatedly shown to increase risk for psychiatric illness, including depression.
|
27485401 |
2017 |
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Recent human studies show that DNA methylation changes of hypothesis-driven candidate gene regions, such as the promoter of the glucocorticoid receptor and the serotonin transporter, were associated with maternal depression in peripheral tissue samples of newborns' cord blood, infants' saliva, or adults' peripheral blood.
|
28714605 |
2017 |