Disease: Hypertensive disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 GeneticVariation group BEFREE We applied appropriate statistical methods to analyze the association of occupational stress and glucocorticoid receptor (GR) gene polymorphism with the presence of hypertension. 30545316 2018
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 GeneticVariation group BEFREE This provides a mechanistic basis to understand the hypertension associated with loss-of-function polymorphisms in GR in the context of habitually high salt intake. 30038578 2018
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 AlteredExpression group BEFREE We hypothesized that HDAC inhibition (HDACi) decreased transcriptional activity of glucocorticoid receptor (GR), which ameliorates hypertension and hyperglycemia in patients with CS. 28928236 2018
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 GeneticVariation group BEFREE We recommend determination of the 24-h urinary free cortisol excretion and sequencing of the NR3C1 gene in patients with hyperandrogenism and/or hypertension of unknown origin. 25715669 2015
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 Biomarker group BEFREE Importantly, GR agonist significantly increased blood pressure and redox markers in TG mice with Hap-6A of the hAGT gene. 25568318 2015
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 GeneticVariation group BEFREE Mutations in NR3C1 do not seem to be common causes for hypertension with low renin and aldosterone levels. 23076843 2013
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 Biomarker group BEFREE We propose thus that GR haploinsufficiency compromises glucocorticoid sensitivity and may represent a novel genetic cause of subclinical hypercortisolism, incidentally revealed bilateral adrenal hyperplasia and mineralocorticoid-independent hypertension. 21042587 2010
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 Biomarker group CTD_human The glucocorticoid receptor is required for experimental adrenocorticotrophic hormone-induced hypertension in mice. 20659135 2010
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 Biomarker group RGD A putative role for hypothalamic glucocorticoid receptors in hypertension induced by prenatal undernutrition in the rat. 20674672 2010
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 Biomarker group BEFREE Thus, reduced GR density balanced by HPA activation leaves glucocorticoid functions unaffected but mineralocorticoid functions increased, causing hypertension. 18697839 2008
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 Biomarker group CTD_human A critical role for vascular smooth muscle in acute glucocorticoid-induced hypertension. 18434569 2008
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 GeneticVariation group LHGDN A novel point mutation in the amino terminal domain of the human glucocorticoid receptor (hGR) gene enhancing hGR-mediated gene expression. 18827003 2008
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 GeneticVariation group BEFREE The NR3C1 N363S variant is associated with obesity and overweight in a range of patient settings but is not associated with hypertension or type 2 diabetes. 12805402 2003
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 GeneticVariation group BEFREE For instance, the BclI polymorphism within the intron upstream of GR exon 2 has been associated with cardiovascular risk factors such as visceral obesity, hypertension, insulin resistance, and elevated cortisol concentrations. 12376590 2002
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 GeneticVariation group BEFREE Studies in humans have associated glucocorticoid receptor (GR) polymorphisms with high blood pressure, insulin sensitivity, body mass index, increased visceral fat, and variations in tissue-specific steroid sensitivity. 11344238 2001
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 Biomarker group BEFREE No comparable mechanisms of hypertension following glucocorticoid receptor occupancy have been documented to date. 8564448 1995
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 GeneticVariation group BEFREE Cross-sectional analyses are reasonably powerful, require no knowledge of mode of transmission and have been used to show the association of variants of the insulin receptor, dipeptidyl carboxypeptidase-1 and glucocorticoid receptor genes with hypertension, using relatively low numbers of subjects having a strong genetic component to their elevated blood pressure. 8096533 1993
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 Biomarker group HPO