Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.330 GeneticVariation disease BEFREE This study examined the effects of glucocorticoid receptor (NR3C1), corticotropin-releasing hormone receptor 1 (CRHR1), and brain-derived neurotrophic factor (BDNF) genes on susceptibility to crack cocaine addiction and BDNF levels. 28237884 2017
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.330 Biomarker disease BEFREE Glucocorticoid receptor gene modulates severity of depression in women with crack cocaine addiction. 27397864 2016
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.330 GeneticVariation disease BEFREE The aim of this study was to analyze hypotheses-driven gene-environment and gene-gene interactions in smoked (crack) cocaine addiction by evaluating childhood neglect and polymorphisms in mineralocorticoid and glucocorticoid receptor genes (NR3C2 and NR3C1, respectively). 26228405 2015
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.330 Biomarker disease CTD_human Stress and addiction: glucocorticoid receptor in dopaminoceptive neurons facilitates cocaine seeking. 19234455 2009
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.330 Biomarker disease CTD_human This suggests that targeting GR function in the brain could provide new therapeutic strategies to treat cocaine addiction for which there is no available treatment. 12805318 2003