Brugada Syndrome (disorder)
|
0.550 |
GeneticVariation
|
disease |
BEFREE |
The nonsense p.E61X genetic variation in the RANGRF gene has been postulated as responsible for Brugada syndrome although no clear association has been established.
|
24142675 |
2014 |
Brugada Syndrome (disorder)
|
0.550 |
Biomarker
|
disease |
BEFREE |
Previously, the genes SCN1B, SCN3B, MOG1, and KCND3 have been associated with BrS.
|
22284586 |
2012 |
Brugada Syndrome (disorder)
|
0.550 |
Biomarker
|
disease |
BEFREE |
MOG1 was screened by direct sequencing in patients with BrS and idiopathic ventricular fibrillation.
|
21447824 |
2011 |
Brugada Syndrome (disorder)
|
0.550 |
GeneticVariation
|
disease |
BEFREE |
However, the molecular basis for the MOG1/Nav1.5 interaction and how the E83D substitution causes BrS remains unknown.
|
30282806 |
2018 |
Brugada Syndrome (disorder)
|
0.550 |
Biomarker
|
disease |
BEFREE |
We here screened the coding sequence, the flanking intronic regions as well as the 5' and 3'UTR regions of SCN5A gene and further five candidate genes (GPD1L, SCN1B, KCNE3, SCN4B, and MOG1) in a Tunisian family diagnosed with BrS.
|
31627867 |
2019 |
Cardiac Arrhythmia
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
RAN guanine nucleotide release factor (RANGRF) encoding protein MOG1 plays an important role in cardiac arrhythmia, so we intended to investigate the regulatory miRNA of RANGRF and explore its potential regulatory mechanism in arrhythmogenesis.
|
28796037 |
2017 |
Cardiac Arrhythmia
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
A novel nonsense variant in Nav1.5 cofactor MOG1 eliminates its sodium current increasing effect and may increase the risk of arrhythmias.
|
21621375 |
2011 |
Paroxysmal familial ventricular fibrillation
|
0.010 |
Biomarker
|
disease |
BEFREE |
MOG1 was screened by direct sequencing in patients with BrS and idiopathic ventricular fibrillation.
|
21447824 |
2011 |
Adverse Event Associated with Cardiac Arrhythmia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
RAN guanine nucleotide release factor (RANGRF) encoding protein MOG1 plays an important role in cardiac arrhythmia, so we intended to investigate the regulatory miRNA of RANGRF and explore its potential regulatory mechanism in arrhythmogenesis.
|
28796037 |
2017 |
Adenocarcinoma of lung (disorder)
|
0.300 |
Biomarker
|
disease |
CTD_human |
c-Myc targeted regulators of cell metabolism in a transgenic mouse model of papillary lung adenocarcinoma.
|
27602772 |
2016 |
Cardiac Arrest
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Paroxysmal ventricular tachycardia
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Sick Sinus Syndrome
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Syncope
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Supraventricular tachycardia
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Ventricular Fibrillation
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
First degree atrioventricular block
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Right bundle branch block
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Trifascicular block
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
ST segment elevation (finding)
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
AV Block First Degree by ECG Finding
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Brugada Syndrome (disorder)
|
0.550 |
GeneticVariation
|
disease |
ORPHANET |
The nonsense p.E61X genetic variation in the RANGRF gene has been postulated as responsible for Brugada syndrome although no clear association has been established.
|
24142675 |
2014 |
Experimental Autoimmune Encephalomyelitis
|
0.200 |
Biomarker
|
disease |
RGD |
The N-terminal domain of the myelin oligodendrocyte glycoprotein (MOG) induces acute demyelinating experimental autoimmune encephalomyelitis in the Lewis rat.
|
8557821 |
1995 |
Brugada Syndrome (disorder)
|
0.550 |
Biomarker
|
disease |
CLINGEN |
MOG1 was screened by direct sequencing in patients with BrS and idiopathic ventricular fibrillation.
|
21447824 |
2011 |
Brugada Syndrome (disorder)
|
0.550 |
Biomarker
|
disease |
CLINGEN |
Use of MOG1 to enhance Na(v)1.5 trafficking to PM may be a potential personalized therapeutic approach for some patients with Brugada syndrome, dilated cardiomyopathy, and sick sinus syndrome in the future.
|
23420830 |
2013 |