Recently, five novel single nucleotide polymorphisms (SNPs), rs10937625 in <i>STK32B</i> (serine/threonine kinase 32B), rs17590046 in <i>PPARGC1A</i> (peroxisome proliferator-activated receptor gamma coactivator 1-alpha), and rs12764057, rs10822974, and rs7903491 in <i>CTNNA3</i> (catenin alpha 3), were found to be associated with increased risk of essential tremor (ET) in a genome-wide association study (GWAS)in individuals of Caucasian ancestry.
Our research supports that C allele of rs10937625 in STK32B is a protective factor and G allele of rs7903491 in CTNNA3 is a risk factor for ET in Chinese population.