CXCL1, C-X-C motif chemokine ligand 1, 2919

N. diseases: 315; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.030 AlteredExpression disease LHGDN Growth-regulated oncogene-1 expression is associated with angiogenesis and lymph node metastasis in human oral cancer. 15218300 2004
CUI: C0153381
Disease: Malignant neoplasm of mouth
Malignant neoplasm of mouth 		0.030 AlteredExpression group BEFREE A previous article noted that GRO-1 was upregulated in oral cancer using a genome-wide microarray approach. 15218300 2004
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma 		0.030 AlteredExpression disease BEFREE A previous article noted that GRO-1 was upregulated in oral cancer using a genome-wide microarray approach. 15218300 2004
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.100 Biomarker phenotype BEFREE We previously performed gene expression profiling in a multistep squamous cell carcinoma (SCC) progression model, and identified growth-regulated oncogene-1 (Gro-1/KC) as a factor that contributes to enhanced angiogenesis, tumorigenesis and metastasis. 15221009 2004
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.050 Biomarker phenotype BEFREE We previously performed gene expression profiling in a multistep squamous cell carcinoma (SCC) progression model, and identified growth-regulated oncogene-1 (Gro-1/KC) as a factor that contributes to enhanced angiogenesis, tumorigenesis and metastasis. 15221009 2004
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.030 Biomarker disease BEFREE We previously performed gene expression profiling in a multistep squamous cell carcinoma (SCC) progression model, and identified growth-regulated oncogene-1 (Gro-1/KC) as a factor that contributes to enhanced angiogenesis, tumorigenesis and metastasis. 15221009 2004
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.100 Biomarker phenotype BEFREE These included growth regulated oncogene alpha (GROalpha/GRO1/CXCL1), another neutrophil chemoattractant implicated in tumor angiogenesis and metastasis. 15256456 2004
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.050 Biomarker phenotype BEFREE These included growth regulated oncogene alpha (GROalpha/GRO1/CXCL1), another neutrophil chemoattractant implicated in tumor angiogenesis and metastasis. 15256456 2004
CUI: C0037274
Disease: Dermatologic disorders
Dermatologic disorders 		0.020 Biomarker group LHGDN The lesional skin of linear IgA bullous dermatosis expresses growth-regulated peptide (GRO)-alpha. 15492419 2004
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.060 AlteredExpression disease BEFREE These data demonstrate that the constitutive expression of CXCL1 and its receptor CXCR2 is associated with metastatic potential and modulates colon cancer cell proliferation and an invasive phenotype. 15787094 2004
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.050 AlteredExpression disease BEFREE These data demonstrate that the constitutive expression of CXCL1 and its receptor CXCR2 is associated with metastatic potential and modulates colon cancer cell proliferation and an invasive phenotype. 15787094 2004
CUI: C4744565
Disease: Metastatic Colon Carcinoma
Metastatic Colon Carcinoma 		0.010 AlteredExpression disease BEFREE Non-metastatic and low metastatic cells expressed lower levels of CXCL1 and CXCR2 mRNA and protein as compared to high metastatic colon carcinoma cells. 15787094 2004
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.030 GeneticVariation disease BEFREE Therefore, the data presented here suggests that the CXCL1 gene could not be associated with the susceptibility to AD in a Japanese population. 15843053 2005
CUI: C0025202
Disease: melanoma
melanoma 		0.100 Biomarker disease BEFREE In addition, the melanoma growth and migration stimulatory chemokines CXCL1 and CXCL2 were significantly up-regulated in the cocultured fibroblasts. 15899804 2005
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.100 Biomarker disease BEFREE Three markers, heat shock protein 70 (HSP-70), chemokine (C-X-C motif) ligand 1 (CXCL-1), and secreted leukocyte protease inhibitor (SLPI), were studied further with breast cancer tissue microarrays using a novel method of automated quantitative analysis. 15994930 2005
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.100 Biomarker disease BEFREE Three markers, heat shock protein 70 (HSP-70), chemokine (C-X-C motif) ligand 1 (CXCL-1), and secreted leukocyte protease inhibitor (SLPI), were studied further with breast cancer tissue microarrays using a novel method of automated quantitative analysis. 15994930 2005
CUI: C0025202
Disease: melanoma
melanoma 		0.100 Biomarker disease LHGDN As determined by ELISA, endothelin-1 (ET-1) induces CXCL1 and CXCL8 secretion in three human melanoma cell lines in a concentration-dependent fashion. 16098041 2005
CUI: C0019193
Disease: Hepatitis, Toxic
Hepatitis, Toxic 		0.300 Biomarker disease CTD_human Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils. 16118408 2005
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.300 Biomarker phenotype CTD_human Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils. 16118408 2005
CUI: C1262760
Disease: Hepatitis, Drug-Induced
Hepatitis, Drug-Induced 		0.300 Biomarker disease CTD_human Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils. 16118408 2005
CUI: C3658290
Disease: Drug-Induced Acute Liver Injury
Drug-Induced Acute Liver Injury 		0.300 Biomarker disease CTD_human Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils. 16118408 2005
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Biomarker disease CTD_human Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils. 16118408 2005
CUI: C4279912
Disease: Chemically-Induced Liver Toxicity
Chemically-Induced Liver Toxicity 		0.300 Biomarker disease CTD_human Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils. 16118408 2005
CUI: C0025202
Disease: melanoma
melanoma 		0.100 Biomarker disease BEFREE Another protein, m/z 7,866, was identified as CXC chemokine ligand 1 (CXCL1) or GRO-alpha, a chemokine associated with melanoma formation and some epithelial cancers. 16452192 2006
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.500 Biomarker disease CTD_human Effect of furosemide infusion on renal hemodynamics and angiogenesis gene expression in acute renal ischemia/reperfusion. 16526316 2006