|
Malignant Neoplasms
|
0.370 |
AlteredExpression
|
group |
BEFREE |
The bioactivity of the extracts was tested on the redox activity of PDIA3 disulfide isomerase, an enzyme involved in the regulation of several cellular functions and associated with different diseases such as cancer, prion disorders, Alzheimer's and Parkinson's diseases.
|
30658391 |
2019 |
|
Malignant Neoplasms
|
0.370 |
Biomarker
|
group |
BEFREE |
Multifunctional molecule ERp57: From cancer to neurodegenerative diseases.
|
28723413 |
2018 |
|
Malignant Neoplasms
|
0.370 |
AlteredExpression
|
group |
BEFREE |
GSEA of the Cancer Genome Atlas dataset showed that Kyoto Encyclopedia of Genes and Genomes oxidative phosphorylation and amino sugar and nucleotide sugar metabolism pathways could be correlated with PDIA3 expression; this was further confirmed in AML cells by Western blotting.
|
29844689 |
2018 |
|
Malignant Neoplasms
|
0.370 |
AlteredExpression
|
group |
BEFREE |
In HCT116 colon carcinoma cells, lentiviral depletion of ERp57 resulted in oxidation of PDI and activation of PERK, whereas depletion or chemical inhibition of PDI reduced PERK signaling and sensitized the cancer cells to hypoxia and ER stress.
|
28796255 |
2017 |
|
Malignant Neoplasms
|
0.370 |
Biomarker
|
group |
BEFREE |
It would appear that ER60 protease is involved in breast tumorigenesis and could therefore be a prospective target for cancer therapeutics.
|
22266712 |
2012 |
|
Malignant Neoplasms
|
0.370 |
Biomarker
|
group |
BEFREE |
Unspecifically downregulated proteins include cancer markers involved in apoptotic resistance and endoplasmatic reticulum (ER) stress such as the 78 kDa glucose regulated protein (GRP 78), protein disulfide isomerase A3 (PDIA3, GRP 58), calumenin, and galectin-1, as well as the glycolytic enzymes triose phosphate isomerase, glyceraldehyde phosphodehydrogenase, and phosphoglycerate mutase.
|
20544786 |
2010 |
|
Malignant Neoplasms
|
0.370 |
Biomarker
|
group |
BEFREE |
Moreover, ERp57(low) cancer cells (which failed to expose CRT) treated with anthracyclines were unable to elicit an anti-tumor response in conditions in which control cells were highly immunogenic.
|
18464797 |
2008 |
|
Malignant Neoplasms
|
0.370 |
Therapeutic
|
group |
CTD_human |
Targeting homeostatic mechanisms of endoplasmic reticulum stress to increase susceptibility of cancer cells to fenretinide-induced apoptosis: the role of stress proteins ERdj5 and ERp57.
|
17353921 |
2007 |
|
Liver carcinoma
|
0.340 |
Biomarker
|
disease |
BEFREE |
An examination of whether PDIA3 knockdown induced apoptosis through ER stress revealed that PDIA3 knockdown did not increase ER stress marker, 78 kDa glucose‑regulated protein, in HCC cell lines.
|
30720090 |
2019 |
|
Liver carcinoma
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
PDIA3 repressed DKC1 expression in HCC cells by recognizing the G-quadruplex DNA at the DKC1 location.
|
29672884 |
2018 |
|
Liver carcinoma
|
0.340 |
Biomarker
|
disease |
BEFREE |
Increased ERp57 Expression in HBV-Related Hepatocellular Carcinoma: Possible Correlation and Prognosis.
|
28373975 |
2017 |
|
Neoplasms
|
0.340 |
GeneticVariation
|
group |
BEFREE |
Changes in the expression of the protein disulfide isomerase genes PDIA3 and PDIA6 may increase endoplasmic reticulum stress, leading to cellular instability and neoplasia.
|
26125904 |
2015 |
|
Neoplasms
|
0.340 |
AlteredExpression
|
group |
BEFREE |
Immunohistochemistry revealed that ERp57 expression in 123 cervical cancers was down-regulated compared to cervical intraepithelial neoplasias or normal tissues (p < 0.001).
|
23957851 |
2013 |
|
Liver carcinoma
|
0.340 |
Biomarker
|
disease |
CTD_human |
Hepatocellular carcinoma-associated protein markers investigated by MALDI-TOF MS.
|
21472284 |
2012 |
|
Neoplasms
|
0.340 |
AlteredExpression
|
group |
BEFREE |
In IHC analysis, ER-60 (PDIA3) was significantly overexpressed in both borderline tumors and invasive ovarian cancers (P<0.001).
|
20596667 |
2010 |
|
Neoplasms
|
0.340 |
Biomarker
|
group |
BEFREE |
Moreover, ERp57(low) cancer cells (which failed to expose CRT) treated with anthracyclines were unable to elicit an anti-tumor response in conditions in which control cells were highly immunogenic.
|
18464797 |
2008 |
|
Neoplasms
|
0.340 |
Therapeutic
|
group |
CTD_human |
Targeting homeostatic mechanisms of endoplasmic reticulum stress to increase susceptibility of cancer cells to fenretinide-induced apoptosis: the role of stress proteins ERdj5 and ERp57.
|
17353921 |
2007 |
|
Liver carcinoma
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
A statistically highly significant difference in calreticulin and PDIA3 fragment serum levels between patients with HCC and healthy individuals was observed.
|
16762624 |
2006 |
|
Malignant neoplasm of prostate
|
0.320 |
Biomarker
|
disease |
BEFREE |
LEDGF/p75 Overexpression Attenuates Oxidative Stress-Induced Necrosis and Upregulates the Oxidoreductase ERP57/PDIA3/GRP58 in Prostate Cancer.
|
26771192 |
2016 |
|
Malignant neoplasm of prostate
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Differential expression of apoptotic genes PDIA3 and MAP3K5 distinguishes between low- and high-risk prostate cancer.
|
20035634 |
2009 |
|
Malignant neoplasm of prostate
|
0.320 |
Biomarker
|
disease |
CTD_human |
Proteome analysis of human androgen-independent prostate cancer cell lines: variable metastatic potentials correlated with vimentin expression.
|
17566973 |
2007 |
|
SPINOCEREBELLAR ATAXIA 17
|
0.300 |
Biomarker
|
disease |
CTD_human |
The results illustrate downregulation of proteins involved in the endoplasmic reticulum stress response (HYOU1, HSPA5, PDIA3, and P4HB) and Nrf2-ARE signaling (NQO1 and HMOX1) in SCA17 lymphoblastoid cells.
|
24413982 |
2014 |
|
Acute Coronary Syndrome
|
0.300 |
Biomarker
|
disease |
CTD_human |
"Proteomic changes related to ""bewildered"" circulating platelets in the acute coronary syndrome."
|
21751358 |
2011 |
|
Prostatic Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Proteome analysis of human androgen-independent prostate cancer cell lines: variable metastatic potentials correlated with vimentin expression.
|
17566973 |
2007 |
|
Benign Neoplasm
|
0.300 |
Therapeutic
|
group |
CTD_human |
Targeting homeostatic mechanisms of endoplasmic reticulum stress to increase susceptibility of cancer cells to fenretinide-induced apoptosis: the role of stress proteins ERdj5 and ERp57.
|
17353921 |
2007 |