Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.340 GeneticVariation group BEFREE Changes in the expression of the protein disulfide isomerase genes PDIA3 and PDIA6 may increase endoplasmic reticulum stress, leading to cellular instability and neoplasia. 26125904 2015
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.340 AlteredExpression group BEFREE Immunohistochemistry revealed that ERp57 expression in 123 cervical cancers was down-regulated compared to cervical intraepithelial neoplasias or normal tissues (p < 0.001). 23957851 2013
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.340 AlteredExpression group BEFREE In IHC analysis, ER-60 (PDIA3) was significantly overexpressed in both borderline tumors and invasive ovarian cancers (P<0.001). 20596667 2010
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.340 Biomarker group BEFREE Moreover, ERp57(low) cancer cells (which failed to expose CRT) treated with anthracyclines were unable to elicit an anti-tumor response in conditions in which control cells were highly immunogenic. 18464797 2008
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.340 Therapeutic group CTD_human Targeting homeostatic mechanisms of endoplasmic reticulum stress to increase susceptibility of cancer cells to fenretinide-induced apoptosis: the role of stress proteins ERdj5 and ERp57. 17353921 2007