GRPR, gastrin releasing peptide receptor, 2925

N. diseases: 85; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.100 Biomarker disease BEFREE Synergistic consequences of GRP-R inhibition and DCA treatment may suggest a novel therapeutic strategy for the treatment of aggressive neuroblastoma. 25630799 2015
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.100 Biomarker disease BEFREE Herein, we sought to characterize miRNA profile in GRP-R silenced neuroblastoma cells, and to determine the role of miRNAs on tumorigenicity and metastatic potential. 23806264 2013
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.100 PosttranslationalModification disease BEFREE Single-walled carbon nanotube-mediated small interfering RNA delivery for gastrin-releasing peptide receptor silencing in human neuroblastoma. 23749575 2013
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.100 Biomarker disease BEFREE We hypothesize that inhibition of GRPR enhances autophagy-mediated degradation of GRP and subsequent inhibition of angiogenesis in neuroblastoma. 24108003 2013
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.100 AlteredExpression disease BEFREE We also confirmed that GRP-R is upstream of AKT2 and in turn, regulated N-myc expression via AKT2 in neuroblastoma cells. 23468863 2013
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.100 AlteredExpression disease BEFREE We found that FAK expression correlates with GRP-R expression in human neuroblastoma sections and cell lines. 23211542 2012
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.100 PosttranslationalModification disease BEFREE These findings provide evidence that a GRPR antagonist can stimulate the growth of cancer cells, and suggest that GRPR might interact with epigenetic mechanisms in regulating neuroblastoma cell growth. 19426821 2009
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.100 AlteredExpression disease BEFREE Conversely, overexpression of GRP-R in less aggressive SK-N-SH neuroblastoma cells resulted in soft agar colony formation, which was inhibited by a GRP-blocking antibody. 18753628 2008
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.100 Biomarker disease BEFREE Human neuroblastoma cell lines (SK-N-SH and SH-SY5Y) were stably transfected with the plasmid pEGFP-GRP-R to establish GRP-R overexpression cell lines, and the effects of GRP on PTEN gene and protein expression were determined. 15849504 2005
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.100 AlteredExpression disease BEFREE Therefore, the purpose of our study was to determine whether Ets regulates transcriptional activity of GRP-R in NBs. 15300220 2004