Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3714948
Disease: PACHYONYCHIA CONGENITA 3
PACHYONYCHIA CONGENITA 3
0.040 Biomarker disease BEFREE Lu-iPSMA-BN (radiochemical purity>98%) showed specific recognition for PSMA and GRPr (IC50=5.62 and 3.49 nmol/l, respectively) with a significant decrease in cell viability (10.15% of cell viability in LNCaP and 40.10% in PC3 at 48 h), as well as high LNCaP and PC3 tumor uptake (5.21 and 3.21% ID/g at 96 h, respectively). 30763290 2019
CUI: C3714948
Disease: PACHYONYCHIA CONGENITA 3
PACHYONYCHIA CONGENITA 3
0.040 Biomarker disease BEFREE The in vitro stabilities, receptor binding, cell uptake, internalization, and efflux properties of the probes <sup>68</sup>Ga-1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA)-Aca-BBN<sub>7-14</sub> and <sup>68</sup>Ga-NOTA-poly(ethylene glycol)<sub>3</sub> (PEG<sub>3</sub>)-RM26 were studied in PC-3 cells, and the in vivo GRPR targeting abilities and kinetics were investigated using PC-3 tumor xenografted mice. 29254329 2018
CUI: C3714948
Disease: PACHYONYCHIA CONGENITA 3
PACHYONYCHIA CONGENITA 3
0.040 Biomarker disease BEFREE Competitive binding assays in PC3 cancer cells showed that these BBN-containing AuNPs have high affinity for GRPr. 28485418 2017
CUI: C3714948
Disease: PACHYONYCHIA CONGENITA 3
PACHYONYCHIA CONGENITA 3
0.040 AlteredExpression disease BEFREE The PC-3 tumor cell line has an elevated expression of GRP-Rs (2.5 x 10(5)/cell), whereas LNCaP--a prostate cancer metastatic cell line representing the early androgen-sensitive stage of prostate cancer--and DU145--an androgen-insensitive metastatic line--express lower receptor numbers (5.9 x 10(3) and 1.2 x 10(4)/cell, respectively). 19910427 2009