GSK3B, glycogen synthase kinase 3 beta, 2932

N. diseases: 393; N. variants: 25
Disease: Enzyme inhibition disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0877008
Disease: Enzyme inhibition disorder
Enzyme inhibition disorder 		0.030 Biomarker phenotype BEFREE Synthesis of coumarin derivatives as versatile scaffolds for GSK-3β enzyme inhibition. 31648640 2020
CUI: C0877008
Disease: Enzyme inhibition disorder
Enzyme inhibition disorder 		0.030 AlteredExpression phenotype BEFREE Overall, the enzyme inhibition assays demonstrated the prominence of mulberrofuran D2 as an inhibitor of AChE, BChE, BACE1, and GSK-3β enzymes with IC<sub>50</sub> values of 4.61, 1.51, 0.73, and 6.36 μM, respectively. 31459768 2019
CUI: C0877008
Disease: Enzyme inhibition disorder
Enzyme inhibition disorder 		0.030 Biomarker phenotype BEFREE The number of viable cells and mitochondrial membrane potential were increased following GSK-3β enzyme inhibition against MPP⁺. 30965670 2019