Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Malignant neoplasm of colon and/or rectum
0.080 Biomarker disease BEFREE PIK3CD induces cell growth and invasion by activating AKT/GSK-3β/β-catenin signaling in colorectal cancer. 30618098 2019
Malignant neoplasm of colon and/or rectum
0.080 AlteredExpression disease BEFREE Mutations in APC that disrupt the regulation of β-catenin by GSK-3β cause colorectal cancer in humans. 28057765 2017
Malignant neoplasm of colon and/or rectum
0.080 Biomarker disease BEFREE Gankyrin sustains PI3K/GSK-3β/β-catenin signal activation and promotes colorectal cancer aggressiveness and progression. 27835604 2016
Malignant neoplasm of colon and/or rectum
0.080 PosttranslationalModification disease BEFREE Mutations in the β-catenin gene in the region of serine-threonine glycogen kinase (GSK)-3β phosphorylation target sites have been identified in colorectal cancer in humans. 26373808 2016
Malignant neoplasm of colon and/or rectum
0.080 Biomarker disease BEFREE Taken together, our results demonstrated that therapeutic targeting of ROS/GSK-3β/NF-κB pathways may be an effective way for colorectal cancer intervention, although further preclinical and clinical testing are desirable. 25002914 2014
Malignant neoplasm of colon and/or rectum
0.080 Biomarker disease BEFREE Epithelial-mesenchymal transition (EMT) induced by TNF-α requires AKT/GSK-3β-mediated stabilization of snail in colorectal cancer. 23431386 2013
Malignant neoplasm of colon and/or rectum
0.080 Biomarker disease BEFREE In this study, we report that p53 regulates GSK-3β nuclear localization via miR-34-mediated suppression of Axin2 in colorectal cancer. 23624843 2013
Malignant neoplasm of colon and/or rectum
0.080 AlteredExpression disease BEFREE RKIP levels in human colorectal cancer positively correlate with GSK3β expression. 21303975 2011