GSTM1, glutathione S-transferase mu 1, 2944

N. diseases: 627; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.380 GeneticVariation disease BEFREE This study demonstrated that the GSTM1 null and combined GSTM1/GSTT1 null genotypes are susceptibility factors for development of atherosclerosis in a Serbian population. 29658969 2019
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.380 GeneticVariation disease BEFREE In addition, the GSTM1 present genotype was more frequent in individuals who reported being former smokers - 45.5% in individuals with atherosclerosis who smoked for more than 20 years and 50% each for individuals in the control group who smoked for less than 10 years or for 10 to 20 years, respectively (P = 0.0240). 28362975 2017
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.380 GeneticVariation disease BEFREE The aim of our study was to analyze the possible association of GSTM1 and GSTT1 gene polymorphisms with the occurrence of carotid plaque (CP); and biochemical parameters of oxidative stress, lipid profile and inflammation, in 346 consecutive patients with advanced atherosclerosis that underwent endarterectomy. 24407598 2014
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.380 GeneticVariation disease BEFREE The GSTT1-0 genotype and GSTT1-0/GSTM1-0 haplotype might be a potential determinants of susceptibility to advanced atherosclerosis in patients with type 2 diabetes mellitus. 22330623 2012
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.380 Biomarker disease CTD_human Across species, genetic variants that result in decreased expression of the Gstm1 gene are associated with increased susceptibility for vascular diseases, including atherosclerosis in humans. 19822795 2009
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.380 GeneticVariation disease BEFREE We estimated the effect of interaction of smoking with the deletion polymorphisms of GSTM1 and GSTT1 on the risk of carotid artery atherosclerosis. 12859033 2003
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.380 GeneticVariation disease BEFREE GSTM1 gene deletion, which has been associated with an increased risk of cancer at various sites and molecular lesions in atherosclerosis, predisposes to more severe oxidative DNA damage in glaucoma patients. 12798451 2003
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.380 GeneticVariation disease BEFREE Furthermore, the combined genotypes GSTM1 null/ CYP2E1(*)5B, GSTM1 null/mEH YY, and GSTT1 null/mEH YY are significantly associated with susceptibility to AR (OR = 15.42, 95% CI = 1.33-77.93, P = 0.021; OR = 3.48, 95% CI = 1.63-8.04, P = 0.0008; OR = 3.4; 95% CI = 0.99-17.38, P = 0.05; respectively). 12355548 2002
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.380 GeneticVariation disease BEFREE In the vitamin E group no effect of GSTM1 genotype on atherosclerosis progression was found. 11500195 2001