|
Renal Cell Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Relationship of the GSTM1-null genotype with clinical TNM stage of RCC was not observed in the overall population of Asians or Caucasians.
|
29884137 |
2018 |
|
Renal Cell Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Finally, the presence of GSTM1:ASK1 protein-protein interaction was found in all RCC tissue samples studied.
|
28284893 |
2017 |
|
Renal Cell Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Subgroup analysis of occupational exposure to pesticides showed an inverse association of the active genotypes of both GSTM1 and GSTT1 polymorphisms with the exposed group of RCC (P<0.00001 and P<0.00001, respectively).
|
27185341 |
2016 |
|
Renal Cell Carcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
This meta-analysis suggests that there may be a relationship between the GSTM1 and GSTT1 wild-type genotype and RCC.
|
26656529 |
2015 |
|
Renal Cell Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis suggests that there may be a relationship between the GSTM1 and GSTT1 wild-type genotype and RCC.
|
26656529 |
2015 |
|
Renal Cell Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, the GSTM1-GSTT1 interaction analysis showed that the dual null genotype of GSTM1/GSTT1 was significantly associated with an increased RCC risk (odds ratio (OR) = 1.42, 95% CI 1.14-1.76, P = 0.001).
|
24337975 |
2014 |
|
Renal Cell Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
No relationship between GSTT1 and GSTM1 genotypes and RCC risk was observed.
|
21458313 |
2013 |
|
Renal Cell Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The GSTM1 and GSTT1 active genotypes in subjects exposed to pesticides (GSTM1: OR = 3.44; 95% CI, 2.04-5.80; GSTT1: OR = 2.84; 95% CI, 1.75-4.60), most of the GSTs genotypes in Asian populations (GSTT1: OR = 2.39, 95% CI = 1.63-3.51; GSTP1: Dominant model: OR = 1.50, 95% CI = 1.14-1.99; Additive model: OR = 1.39, 95% CI = 1.12-1.73; AG vs. AA: OR = 1.47, 95% CI = 1.10-1.97; GG vs. AA: OR = 1.82, 95% CI = 1.07-3.09) and the dual null genotype of GSTT1-GSTP1 (OR = 2.84, 95% CI = 1.75-4.60) showed positive associations with the RCC risk.
|
23717494 |
2013 |
|
Renal Cell Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The cumulative meta-analyses showed a trend of no obvious association between GSTM1 null genotype and risk of RCC as information accumulated.
|
22994718 |
2012 |
|
Renal Cell Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, the dual null genotype of GSTM1-GSTT1 was associated with RCC risk in Asians (N = 1, OR = 2.06, 95% CI: 1.36-3.13, p = 0.007).
|
22880812 |
2012 |
|
Renal Cell Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this study, we investigated the association of GSTP1, GSTM1, and GSTP1 genetic variants with renal cell carcinoma (RCC) among North Indian patients.
|
22054067 |
2012 |
|
Renal Cell Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Renal cell carcinoma Fuhrman grade and histological subtype correlate with complete polymorphic deletion of glutathione S-transferase M1 gene.
|
20083259 |
2010 |
|
Renal Cell Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The effects of GSTM1 and GSTT1 polymorphism on susceptibility to RCC depend on exposure to specific chemicals.
|
19424176 |
2009 |
|
Renal Cell Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the largest RCC case-control study with genotype information conducted to date, we observed that risk associated with pesticide exposure was exclusive to individuals with active GSTM1/T1 genotypes.
|
18566013 |
2008 |
|
Renal Cell Carcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
In the largest RCC case-control study with genotype information conducted to date, we observed that risk associated with pesticide exposure was exclusive to individuals with active GSTM1/T1 genotypes.
|
18566013 |
2008 |
|
Renal Cell Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Results support the hypothesis that GSTM1 and GSTT1 polymorphisms can interact with several occupational exposures to significantly modify the risk of RCC among exposed subjects.
|
14504370 |
2003 |
|
Renal Cell Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Glutathione S-transferase M1, T1, and P1 polymorphisms as risk factors for renal cell carcinoma: a case-control study.
|
10794492 |
2000 |
|
Renal Cell Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Odds ratio for renal cell cancer were 2.7 for GSTM1 + individuals (95% CI, 1.18-6.33; P < 0.02) and 4.2 for GSTT1 + individuals (95% CI, 1.16-14.91; P < 0.05), respectively.
|
9285043 |
1997 |