Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease BEFREE GSTM1 exhibited a significant association with increased risk of squamous cell carcinoma (p < 0.001). 25663492 2015
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 GeneticVariation disease BEFREE Effect of GSTM1 polymorphism on risks of basal cell carcinoma and squamous cell carcinoma: a meta-analysis. 23184764 2013
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 GeneticVariation disease BEFREE GSTT1, GSTM1, GSTP1 polymorphism did not show any significant association with SCC. 22248273 2012
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease CTD_human Moreover, a significant increase in the risk to SCC of lung in the cases carrying combination of variant genotype of CYP1A2 with either CYP1A1 or GSTM1 have shown that gene-gene interactions may play an important role in squamous cell lung cancer risk. 22072123 2012
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 GeneticVariation disease BEFREE The frequency of one null genotype of the GSTM1 or GSTT1 gene was higher in patients with pharyngeal SCC and heavy smoking status than in controls (76.3% versus 57.7%, P = 0.04). 21870186 2012
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 GeneticVariation disease BEFREE Moreover, a significant increase in the risk to SCC of lung in the cases carrying combination of variant genotype of CYP1A2 with either CYP1A1 or GSTM1 have shown that gene-gene interactions may play an important role in squamous cell lung cancer risk. 22072123 2012
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 GeneticVariation disease BEFREE The genotype for GSTM1 (mutation vs. wild type) was determined by polymerase chain reaction (PCR) using genomic DNA extracted from peripheral blood from 28 OSCC patients. 20060357 2011
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 GeneticVariation disease BEFREE When analyzed by histology the GSTM1 null genotype was more prevalent in squamous-cell carcinoma and adenocarcinoma patients. 19669596 2010
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 GeneticVariation disease BEFREE GSTM1 polymorphisms seem to be involved in BCC risk, while GSTM1 null/null genotype combined with CYP1A1 allele Val(462) are associated with a higher risk for SCC, indicating that allelism and/or interactions between allelic variants at other loci may also influence the risk of NMSC, particularly SCC. 17083362 2007
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 GeneticVariation disease LHGDN Individuals with this genotype are hight susceptibble to oral squamous cell carcinoma. 17461521 2007
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 GeneticVariation disease LHGDN In this study the authors were unable to show a correlation between GSTM1 and GSTT1 genotypes and the development of head and neck squamous cell carcinomas in cigarette smokers. 17221058 2007
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 GeneticVariation disease BEFREE In agreement with some literature data, our results support the concerted role of CYP1A1 and GSTM1 at-risk genotypes in SCC predisposition. 16416283 2007
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 AlteredExpression disease BEFREE Relationship between genetic polymorphisms of metabolizing enzymes CYP2E1, GSTM1 and Kazakh's esophageal squamous cell cancer in Xinjiang, China. 15968714 2005
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 GeneticVariation disease BEFREE Accumulation of certain alleles or genotypes of the CYP1A1, NAT2, GSTM1 and XPD seems to be associated with either increased or decreased risk to develop laryngeal SCC. 15914211 2005
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 GeneticVariation disease BEFREE The purpose of this study was to evaluate the prognostic ability of polymorphisms of three genes involved in the metabolism of tobacco carcinogens (GSTT1, GSTM1, GSTP1) and one polymorphism of a DNA repair gene (XRCC1) for patients diagnosed with squamous cell carcinoma (SCC). 15668931 2005
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 GeneticVariation disease LHGDN genotype may be important marker for the age of onset and risk of metastasis in oral squamous cell carcinoma 16091114 2005
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 AlteredExpression disease LHGDN GSTM1*2/* 2 and CYP1A1*1A/* 2C genotype frequencies were higher among squamous cell carcinomas at a level close to statistical significance 15526353 2005
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 GeneticVariation disease BEFREE GSTM1 polymorphism and oral squamous cell carcinoma. 14662415 2004
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 GeneticVariation disease BEFREE Furthermore, in agreement with mechanistic considerations, the GSTM1 null genotypes were more prevalent in squamous cell carcinoma patients (58%) and in lung cancer patients with seemingly low cumulative carcinogen exposure dose (non-smokers: 63%; patients aged below 50 years: 76%). 15165083 2004
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 GeneticVariation disease LHGDN genetic polymorphisms of GSTM1 found in head and neck squamous cell carcinoma 12748560 2003
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 GeneticVariation disease BEFREE Among AC and SCC cancer patients, individuals with the GSTM1-null genotype had an OR of 1.80 (95% CI, 1.1-2.8; case-only analysis) of having AC versus SCC if they also carried a p53 Pro allele. 11751390 2002
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 GeneticVariation disease BEFREE The GSTM1 null genotype was associated with a decreased risk of squamous cell carcinoma: the OR, adjusted for age, sex and pack years was 0.32 (95% CI 0.12-0.82). 12175548 2002
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 GeneticVariation disease BEFREE To investigate the relation between GSTM1 genotype and K-ras gene mutation we examined 193 adenocarcinomas and 119 squamous cell carcinomas of lung. 11470766 2001
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 Biomarker disease BEFREE Analysis of the interaction between GSTM1 null and sunbathing score showed that the two factors were synergistic and individuals with both risk parameters demonstrated a shorter time from transplantation to development of the first SCC (p = 0.012, hazard ratio = 7.1). 11511301 2001
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.400 GeneticVariation disease BEFREE These results are supported by logistic regressions of patients allowing interactions between tumour type (or treatment) and PY (or age), and indicate that the GSTM1-null genotype could be an important susceptibility factor for SQ while the NAT2-slow genotype may have an impact on other types of lung cancer. 10607733 2000