GSTM1, glutathione S-transferase mu 1, 2944

N. diseases: 627; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Chemical and Drug Induced Liver Injury
0.500 Biomarker disease RGD Identification of liver proteins and their roles associated with carbon tetrachloride-induced hepatotoxicity. 21138988 2011
Chemical and Drug Induced Liver Injury
0.500 Biomarker disease CTD_human Glutathione S-transferase m1 and t1 null genotypes increase susceptibility to idiosyncratic drug-induced liver injury. 18666253 2008
Chemical and Drug Induced Liver Injury
0.500 Biomarker disease CTD_human Glutathione S-transferase M1 null genotype as a risk factor for carbamazepine-induced mild hepatotoxicity. 17465707 2007
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 GeneticVariation disease BEFREE Herein, we investigated the relationship of three GSTs polymorphisms (GSTT1 deletion, GSTM1 deletion, GSTP1 rs1695) as well as GSTP1 promoter region DNA methylation and HCC risk with a particular focus on the interaction with OCPs exposure among 90 HCC cases and 99 controls in a Chinese population. 31731000 2020
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease BEFREE The combination of higher CG methylation levels of <i>LMO2_E148, IL10_P325</i>, and <i>GSTM1_P266</i> corresponded to the highest risk of asthma by 43.48%, compared to other combinations (16.67-23.08%) in the 3-way multi-factor dimensionality reduction (MDR) analysis. 31214241 2019
Malignant neoplasm of urinary bladder
0.400 GeneticVariation disease BEFREE This study focuses on the impact of GSTM1 null genotype on bladder cancer patients' outcome. 31646988 2019
Malignant neoplasm of urinary bladder
0.400 GeneticVariation disease BEFREE We aimed to investigate the association of serum organochlorine pesticides (OCPs) and organophosphorus pesticides (OPs) levels and GSTM1/GSTT1 gene polymorphism with bladder cancer (BC). 31009110 2019
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.400 GeneticVariation disease BEFREE We aimed to investigate the association of serum organochlorine pesticides (OCPs) and organophosphorus pesticides (OPs) levels and GSTM1/GSTT1 gene polymorphism with bladder cancer (BC). 31009110 2019
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.400 GeneticVariation disease BEFREE This study focuses on the impact of GSTM1 null genotype on bladder cancer patients' outcome. 31646988 2019
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation disease BEFREE Additionally, patients with combined GSTM1-null/GSTT1-null/GSTA1 low-activity/GSTP1-variant genotype showed 2.71-fold increased risk of developing CRC (p = 0.037). 30694518 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE Separate or combination of GSTM1 and GSTT1 null genotypes (GST gene) were associated with T2DM. 28548478 2019
CUI: C0023418
Disease: leukemia
leukemia
0.400 GeneticVariation disease BEFREE Additionally, GSTM1 null genotype was also significantly correlated with elevated individual susceptibility to leukemia in East Asians. 30659796 2019
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 Biomarker disease BEFREE In the present study, we show the effects of a single dose of Atremorine (5 g, p. o.) on plasma dopamine (DA) response and brain function in PD (n = 183) and the influence that pathogenic (<i>LRRK2</i>), metabolic (<i>CYP2D5, CYP2C9, CYP2C19, CYP3A5, NAT2</i>), transporter (<i>ABCB1</i>), pleiotropic (<i>APOE</i>), and detoxifying genes (<i>CYP1B1, GSTT1, GSTP1, GSTM1, SOD2</i>) involved in the pharmacogenetic network exerts on Atremorine-induced DA response. 31559607 2019
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.400 GeneticVariation disease BEFREE These findings support the hypothesis that certain polymorphisms in genes involved in DNA-repair and carriers of GSTM1 deletion have an increased risk of lung cancer in never-smokers exposed to residential radon. 31446980 2019
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 AlteredExpression disease BEFREE As the relationship between copy number variation and gene expression of GSTM1 in CaP remains unexplored, this study analyzed GSTM1 gene expression and/or dosage effect on CaP risk and aggressiveness. 30595465 2019
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease
0.400 GeneticVariation phenotype BEFREE Previous studies suggest that individuals who are homozygous-null at the GSTM1 or GSTT1 locus may have an increased risk of environmentally related cancers and drug-induced hepatotoxicity. 30471640 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 Biomarker disease BEFREE In vitro, Transwell and doxorubicin (DOX)-induced apoptosis assays revealed that GSTM1 showed opposite functions in different HCC cell lines with varied TP53 genotype statuses. 31605953 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 GeneticVariation disease BEFREE The pooled analysis showed that both GSTM1 null genotypes (OR = 1.37, 95% CI = 1.18-1.59) and GSTT1 null genotypes (OR = 1.43, 95% CI = 1.23-1.66) increased the risk of HCC. 30976200 2019
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease BEFREE Carriers of GSTM1/T1 null and GSTP1 val genotypes were more susceptible to indoor air pollution exposures, having a higher risk of asthma and lung function deficits. 29557517 2018
Malignant neoplasm of urinary bladder
0.400 GeneticVariation disease BEFREE Our meta-analysis suggested that GSTM1-null genotype is associated with an increased bladder cancer risk in the Chinese individuals. 30539835 2018
Malignant neoplasm of urinary bladder
0.400 GeneticVariation disease BEFREE In conclusion, the GSTM1-null, GSTT1-null and dual-null GSTM1-GSTT1 genotypes might be associated with the onset of bladder cancer, but additional genetic-epidemiological studies should be conducted to explore this association further. 30419877 2018
Malignant neoplasm of urinary bladder
0.400 Biomarker disease BEFREE With regard to BC, an overall odds ratio (OR) of 2.07 [95% confidence interval (CI): 1.38-3.09] for those with GSTM1 and an OR of 2.07 (95% CI: 1.38-3.09) for those with GSTT1 null genotype were reported when exposed to polycyclic aromatic hydrocarbons (PAHs). 28403014 2018
Malignant neoplasm of urinary bladder
0.400 GeneticVariation disease BEFREE The common deletion of the glutathione S-transferase Mu 1 (GSTM1) gene in humans has been shown to be involved in xenobiotic metabolism and associated with bladder cancer. 29695243 2018
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.400 GeneticVariation disease BEFREE Our meta-analysis suggested that GSTM1-null genotype is associated with an increased bladder cancer risk in the Chinese individuals. 30539835 2018
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.400 Biomarker disease BEFREE With regard to BC, an overall odds ratio (OR) of 2.07 [95% confidence interval (CI): 1.38-3.09] for those with GSTM1 and an OR of 2.07 (95% CI: 1.38-3.09) for those with GSTT1 null genotype were reported when exposed to polycyclic aromatic hydrocarbons (PAHs). 28403014 2018