GSTM2, glutathione S-transferase mu 2, 2946

N. diseases: 195; N. variants: 11
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0008626
Disease: Congenital chromosomal disease
Congenital chromosomal disease 		0.060 GeneticVariation group BEFREE Chromosomal aberrations in humans induced by urban air pollution: influence of DNA repair and polymorphisms of glutathione S-transferase M1 and N-acetyltransferase 2. 10207633 1999
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma 		0.030 GeneticVariation disease BEFREE Renal cell carcinoma Fuhrman grade and histological subtype correlate with complete polymorphic deletion of glutathione S-transferase M1 gene. 20083259 2010
CUI: C0279702
Disease: Conventional (Clear Cell) Renal Cell Carcinoma
Conventional (Clear Cell) Renal Cell Carcinoma 		0.030 GeneticVariation disease BEFREE Renal cell carcinoma Fuhrman grade and histological subtype correlate with complete polymorphic deletion of glutathione S-transferase M1 gene. 20083259 2010
CUI: C0796135
Disease: Renpenning syndrome 1
Renpenning syndrome 1 		0.010 GeneticVariation disease BEFREE SHS significantly modified the relationship between diplotypes and methylation levels in one GSTM2 CpG site; however, this site did not predict lung function outcomes at age 18. 24004509 2013
CUI: C1834523
Disease: ARTHROGRYPOSIS, DISTAL, TYPE 2B
ARTHROGRYPOSIS, DISTAL, TYPE 2B 		0.010 GeneticVariation disease BEFREE SHS significantly modified the relationship between diplotypes and methylation levels in one GSTM2 CpG site; however, this site did not predict lung function outcomes at age 18. 24004509 2013
CUI: C0524909
Disease: Hepatitis B, Chronic
Hepatitis B, Chronic 		0.010 GeneticVariation disease BEFREE Chronic hepatitis B carriers with null genotypes of glutathione S-transferase M1 and T1 polymorphisms who are exposed to aflatoxin are at increased risk of hepatocellular carcinoma. 8659516 1996
CUI: C0007107
Disease: Malignant neoplasm of larynx
Malignant neoplasm of larynx 		0.040 GeneticVariation disease BEFREE Larynx cancer risk in relation to glutathione S-transferase M1 and T1 genotypes and tobacco smoking. 9456238 1998
CUI: C0023532
Disease: Leukoplakia, Oral
Leukoplakia, Oral 		0.010 Biomarker disease BEFREE Glutathione S-transferase M1 and T1 null genotypes as risk factors for oral leukoplakia in ethnic Indian betel quid/tobacco chewers. 10334189 1999
CUI: C2931822
Disease: Nasopharyngeal carcinoma
Nasopharyngeal carcinoma 		0.030 Biomarker disease BEFREE Glutathione S-transferase M1 and susceptibility to nasopharyngeal carcinoma. 10385146 1999
CUI: C0375071
Disease: Malignant neoplasm of vulva
Malignant neoplasm of vulva 		0.010 GeneticVariation disease BEFREE Glutathione S-transferase M1 genotypes and the risk of vulvar cancer: a population-based case-control study. 10472942 1999
CUI: C0677055
Disease: CARCINOMA OF VULVA
CARCINOMA OF VULVA 		0.010 GeneticVariation disease BEFREE Glutathione S-transferase M1 genotypes and the risk of vulvar cancer: a population-based case-control study. 10472942 1999
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.010 GeneticVariation disease BEFREE Glutathione S-transferase M1 genotypes and the risk of squamous carcinoma of the cervix: a population-based case-control study. 10489995 1999
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.100 Biomarker disease BEFREE Glutathione S-transferase M1 status and lung cancer risk: a meta-analysis. 10744127 1999
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.100 Biomarker disease BEFREE Glutathione S-transferase M1 status and lung cancer risk: a meta-analysis. 10744127 1999
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 Biomarker disease BEFREE Glutathione S-transferase M1 status and lung cancer risk: a meta-analysis. 10744127 1999
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.020 GeneticVariation disease BEFREE Glutathione S-transferase M1 null genotype is associated with a decreased risk of myocardial infarction. 10744635 2000
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma 		0.030 Biomarker disease BEFREE Glutathione S-transferase M1, T1, and P1 polymorphisms as risk factors for renal cell carcinoma: a case-control study. 10794492 2000
CUI: C0279702
Disease: Conventional (Clear Cell) Renal Cell Carcinoma
Conventional (Clear Cell) Renal Cell Carcinoma 		0.030 Biomarker disease BEFREE Glutathione S-transferase M1, T1, and P1 polymorphisms as risk factors for renal cell carcinoma: a case-control study. 10794492 2000
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.030 GeneticVariation group BEFREE Glutathione S-transferase M1 null genotype: lack of association with tumour characteristics and survival in advanced breast cancer. 11056682 1999
CUI: C3495917
Disease: Advanced breast cancer
Advanced breast cancer 		0.010 GeneticVariation disease BEFREE Glutathione S-transferase M1 null genotype: lack of association with tumour characteristics and survival in advanced breast cancer. 11056682 1999
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.100 GeneticVariation disease BEFREE Glutathione S-transferase M1 polymorphism and lung cancer risk in African-Americans. 11062156 2000
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.100 GeneticVariation disease BEFREE Glutathione S-transferase M1 polymorphism and lung cancer risk in African-Americans. 11062156 2000
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 GeneticVariation disease BEFREE Glutathione S-transferase M1 polymorphism and lung cancer risk in African-Americans. 11062156 2000
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.330 GeneticVariation disease BEFREE Glutathione S-transferase M1 gene deletion may be associated with susceptibility to certain forms of schizophrenia. 11181039 2001
CUI: C0005684
Disease: Malignant neoplasm of urinary bladder
Malignant neoplasm of urinary bladder 		0.100 GeneticVariation disease BEFREE Glutathione S-transferase M1 gene polymorphism in bladder cancer patients. a marker for invasive bladder cancer? 11297759 2001