GSTP1, glutathione S-transferase pi 1, 2950

N. diseases: 610; N. variants: 18
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017638
Disease: Glioma
Glioma
0.380 Biomarker disease BEFREE The effects of the changes in MTase levels on global genomic DNA methylation and on the methylation status of CpG dinucleotides in the GSTP1 gene were determined in a glioma cell line that overexpresses the GSTP1 gene. 10760946 2000
CUI: C0017638
Disease: Glioma
Glioma
0.380 GeneticVariation disease BEFREE There was evidence of supermultiplicativity of the joint effect of GSTP1 I105V and CYP2E1 RsaI variants on both glioma and acoustic neuroma, even following adjustment of estimates toward a common prior distribution using hierarchical regression models. 12540498 2003
CUI: C0017638
Disease: Glioma
Glioma
0.380 Biomarker disease BEFREE Polymorphisms in GSTM1, GSTT1, and GSTP1 did not show association with histopathologic type of brain tumor (glioma or meningioma). 15642394 2005
CUI: C0017638
Disease: Glioma
Glioma
0.380 Biomarker disease CTD_human In vitro drug response and molecular markers associated with drug resistance in malignant gliomas. 16899598 2006
CUI: C0017638
Disease: Glioma
Glioma
0.380 Biomarker disease BEFREE We found no associations between the GSTM3, GSTP1, NQO1, CYP1A1, GSTM1, or GSTT1 polymorphisms and adult brain tumor risk with the possible exception of a weak association between the G-C (Val-Ala) GSTP1 105/114 haplotype and glioma [odds ratio (OR), 0.73; 95% confidence interval (95% CI), 0.54, 0.99], nor was there an interaction between the effects of the GSTM3 or GSTP1 polymorphisms and cigarette smoking. 17372252 2007
CUI: C0017638
Disease: Glioma
Glioma
0.380 GeneticVariation disease BEFREE We identified two tSNPs to be associated with glioma susceptibility (rs1695, GSTP1, P = 0.019; rs2853676, TERT, P = 0.039), which we confirmed using dominant and additive model analyses. 22795327 2012
CUI: C0017638
Disease: Glioma
Glioma
0.380 GeneticVariation disease BEFREE The combined results based on all studies showed that there was no association between any of the GST variants and the risk of glioma (for GSTM1: pooled OR = 1.03; 95 % CI, 0.92-1.15; for GSTT1: pooled OR = 1.12; 95 % CI, 0.90-1.40; for GSTP1 I105V: pooled OR = 0.92; 95 % CI, 0.64-1.31 and for GSTP1 A114V: pooled OR = 1.14; 95 % CI, 0.97-1.34). 23079710 2013
CUI: C0017638
Disease: Glioma
Glioma
0.380 GeneticVariation disease BEFREE In conclusion, the meta-analysis suggests that there is no association between GSTP1 Ile105Val polymorphism and glioma risk. 23975366 2014
CUI: C0017638
Disease: Glioma
Glioma
0.380 Biomarker disease BEFREE No significant differences in gene and protein expression were detected between the different types of gliomas, suggesting that glioma chemoresistance is probably multifactorial and GSTP1-independent. 30952719 2019