Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Lung cancer risk associated with individual SNPs was seen for GSTP1 [A allele; odds ratio (OR) = 1.85; 95% confidence interval (CI), 1.04-3.27] and XRCC1 (A/A genotype; OR = 1.68; 95% CI, 1.01-2.79) in white women and CYP1B1 (G allele; OR = 11.1; 95% CI, 1.18-104) in black women smokers.
|
19174490 |
2009 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
There appears to be evidence for interaction between amount of smoking, the GSTP1 exon 5 polymorphism, and risk of lung cancer in whites.
|
19240225 |
2009 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Haplotype-tagging SNPs were selected and GSTP1 haplotypes were tested for genetic association to lung cancer using unconditional logistic regression after adjusting for confounders.
|
19282111 |
2009 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The polymorphisms of GSTP1 Ile105Val and MPO G-463A showed no significant association with lung cancer.
|
17980933 |
2008 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
However, only four of the previously reported associations with polymorphisms in the GSTP1 (Ala14Val), SOD2 (Val16Ala), EPHX1 (His139Arg) genes and the NAT1 fast acetylator phenotype remained significantly associated with lung cancer.
|
18258609 |
2008 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of our study was to measure the frequency of GSTM1, GSTT1, GSTP1*B and p53 gene polymorphisms in a Brazilian population and determine the possible contribution of these genetic variations to LC risk.
|
18280004 |
2008 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The GSTT1 null genotype was also associated with an increased lung cancer risk (OR, 1.49; 95% CI, 1.17-1.89; p=0.001), but no association was observed for the GSTP1 105Val allele.
|
17428724 |
2008 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The study has been extended to investigate the potential role of polymorphism in GSTP1 alone or in combination with the status of GSTM1 and GSTT1 genes in the likelihood of development of lung cancer.
|
18415801 |
2008 |
Malignant neoplasm of lung
|
0.600 |
Biomarker
|
disease |
CTD_mouse |
Glutathione transferase pi plays a critical role in the development of lung carcinogenesis following exposure to tobacco-related carcinogens and urethane.
|
17909032 |
2007 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
After combination study of the three gene-polymorphism, the subjects who were most different with the reference, i.e. had the mutant allele of the GSTP1 and CYP1A1 and homozygous wild type of the MPO, showed approximately 5-fold-higher risk for lung cancer than the reference (95% CI, 2.05-12.05).
|
17428572 |
2007 |
Malignant neoplasm of lung
|
0.600 |
Biomarker
|
disease |
CTD_human |
Glutathione transferase pi plays a critical role in the development of lung carcinogenesis following exposure to tobacco-related carcinogens and urethane.
|
17909032 |
2007 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Interactions between GSTM1, GSTT1 and GSTP1 polymorphisms and smoking and intake of fruit and vegetables in relation to lung cancer.
|
17123660 |
2007 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, individuals possessing combined genotypes of N-acetyltransferase 2 (NAT2) rapid acetylator, GSTP1 mutant and both GSTT1(-) and GSTM1(-) have a remarkably higher lung cancer risk than those carrying combined NAT2 slow acetylator genotype, GSTP1 wild genotype and both GSTT1(+) and GSTM1(+) genotypes.
|
16788248 |
2006 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The risk of lung cancer is not strongly associated with the I105V and A114V polymorphisms in the GSTP1 gene or with GSTM3 intron 6 polymorphism.
|
16509765 |
2006 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The GSTP1 GG genotype was not associated with an overall increased risk of lung cancer (adjusted odds ratio, 1.02; 95% confidence interval [95% CI], 0.78-1.34) compared with the GSTP1 AA genotype.
|
16933328 |
2006 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The interaction between GSTP1 105Val mutation and smoking in the development of lung cancer were not detected, nor was hOGG1 326Cys mutation.
|
15896461 |
2005 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
No significant single gene associations between GSTM1, GSTT1 or GSTP1 and early-onset lung cancer were identified in Caucasians, after adjusting for age, sex, pack years and family history of lung cancer.
|
15661806 |
2005 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Individuals in this high ETS exposure category carrying the GSTM1 null and the GSTP1 Val allele were at over 4-fold increased risk of developing lung cancer (OR = 4.56, 95% CI: 1.21-17.21).
|
15528218 |
2005 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The results showed a 2.4-fold (CI = 1.31-4.41) increased risk of lung cancer in GSTT1 null-genotype carriers but no significant effects of the polymorphisms in GSTM1, GSTM3, GSTP1-105 or GSTP1-114.
|
15069685 |
2004 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
GSTM1 null genotype, combined GSTT1 and GSTM1 null genotype and GSTP1 Val105/Val105 genotype did not confer any increase risk for lung cancer.
|
15246186 |
2004 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In the current German study we investigated the role of GSTM1, GSTT1 and GSTP1 polymorphisms as a genetic modifier of risk for individuals with lung cancer as susceptible genotypes especially in relation to tobacco smoking.
|
15105047 |
2004 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The effect of the GSTP1 polymorphisms on lung cancer risk was evaluated by considering the joint effect of having both an ETS exposure and the GSTP1 GG genotype compared to the absence of ETS exposure and the GSTP1 AA genotype as a reference group as well as doing stratified analysis by genotype.
|
12640684 |
2003 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The GSTP1 GG genotype approximately doubled the lung cancer risk associated with pack-years.
|
14501269 |
2003 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Recent investigations have shown that the GSTM1-null genotype combined with CYP1A1, NAT2, or GSTP1 polymorphisms confers a greater risk of lung cancer than the GSTM1-null genotype alone.
|
12894585 |
2003 |
Malignant neoplasm of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Utilizing a hospital-based case-control study, we investigated the association between GSTP1 polymorphisms at exons 5 and 6 with lung cancer risk.
|
12660004 |
2003 |