GSTP1, glutathione S-transferase pi 1, 2950

N. diseases: 610; N. variants: 18
Disease: Parkinson Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.380 Biomarker disease BEFREE In the present study, we show the effects of a single dose of Atremorine (5 g, p. o.) on plasma dopamine (DA) response and brain function in PD (n = 183) and the influence that pathogenic (<i>LRRK2</i>), metabolic (<i>CYP2D5, CYP2C9, CYP2C19, CYP3A5, NAT2</i>), transporter (<i>ABCB1</i>), pleiotropic (<i>APOE</i>), and detoxifying genes (<i>CYP1B1, GSTT1, GSTP1, GSTM1, SOD2</i>) involved in the pharmacogenetic network exerts on Atremorine-induced DA response. 31559607 2019
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.380 Biomarker disease BEFREE Also, large genetic and environmental studies considering tobacco use, alcoholism, GSTP1 and PD are necessary to confirm our findings. 23857610 2013
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.380 Biomarker disease CTD_human The Nrf2/SKN-1-dependent glutathione S-transferase π homologue GST-1 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of manganism. 23721876 2013
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.380 GeneticVariation disease BEFREE We found evidence of statistically significant gene-tobacco interaction for GSTM1, NAT2, and GSTP1, the negative association between tobacco smoking and PD being significantly enhanced in subjects expressing GSTM1-1 activity, in NAT2 fast acetylators, and in those with the GSTP1*B*C haplotype. 20461808 2010
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.380 Biomarker disease BEFREE An interaction between GSTM1 and GSTP1 was observed in this late onset PD group. 17250723 2007
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.380 GeneticVariation disease BEFREE Nevertheless, our results suggest that further investigation in GSTP1 variants and PD pathogenesis is warranted in sporadic PD and that a search for toxins that accelerate PD OA should pay particular attention to GST-P1 substrates. 17034008 2007
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.380 Biomarker disease CTD_human Using the GenePD Study sample of familial PD cases, we explored whether GSTP1 polymorphisms were associated with the age at onset of PD symptoms and whether that relation was modified by exposure to herbicides. 17190945 2006
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.380 GeneticVariation disease BEFREE Polymorphisms in the glutathione S-transferase pi gene (GSTP1), encoding GSTP1-1, a detoxification enzyme, may increase the risk of Parkinson disease (PD) with exposure to pesticides. 17190945 2006
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.380 GeneticVariation disease BEFREE These data suggest that one or more GSTP1 polymorphisms may interact with cigarette smoking to influence the risk for PD. 15288444 2004
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.380 Biomarker disease BEFREE Taken together, these results suggest a potentially minor role of GSTP1 in PD, but do not give evidence for associations with either GSTM1 or GSTT1. 12524158 2003