Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Conventional (Clear Cell) Renal Cell Carcinoma
0.380 GeneticVariation disease BEFREE This meta-analysis indicated that there was no an association between GSTM1-null genotype, GSTT1-null genotype, GSTP1 A/G gene polymorphism and RCC risk in the overall population of Caucasians or Asians. 29884137 2018
Conventional (Clear Cell) Renal Cell Carcinoma
0.380 GeneticVariation disease BEFREE We noted an increased risk of RCC development in carriers of GSTM1-null and GSTP1-variant genotype (P<0.05). 28284893 2017
Conventional (Clear Cell) Renal Cell Carcinoma
0.380 GeneticVariation disease BEFREE Combined GSTM1-Null, GSTT1-Active, GSTA1 Low-Activity and GSTP1-Variant Genotype Is Associated with Increased Risk of Clear Cell Renal Cell Carcinoma. 27500405 2016
Conventional (Clear Cell) Renal Cell Carcinoma
0.380 GeneticVariation disease BEFREE However, studies on the association between GST (GSTM1, GSTT1, and GSTP1) polymorphisms and RCC remain to be conflicting. 24337975 2014
Conventional (Clear Cell) Renal Cell Carcinoma
0.380 GeneticVariation disease BEFREE The GSTM1 and GSTT1 active genotypes in subjects exposed to pesticides (GSTM1: OR = 3.44; 95% CI, 2.04-5.80; GSTT1: OR = 2.84; 95% CI, 1.75-4.60), most of the GSTs genotypes in Asian populations (GSTT1: OR = 2.39, 95% CI = 1.63-3.51; GSTP1: Dominant model: OR = 1.50, 95% CI = 1.14-1.99; Additive model: OR = 1.39, 95% CI = 1.12-1.73; AG vs. AA: OR = 1.47, 95% CI = 1.10-1.97; GG vs. AA: OR = 1.82, 95% CI = 1.07-3.09) and the dual null genotype of GSTT1-GSTP1 (OR = 2.84, 95% CI = 1.75-4.60) showed positive associations with the RCC risk. 23717494 2013
Conventional (Clear Cell) Renal Cell Carcinoma
0.380 GeneticVariation disease BEFREE The gene-gene interaction in terms of three-way combination of GSTM1 null, GSTT1 null, and GSTP1 (AG/GG) resulted in 4.5-fold increase in RCC risk (OR=4.452; 95% CI=2.220-9.294). 22054067 2012
Conventional (Clear Cell) Renal Cell Carcinoma
0.380 Biomarker disease CTD_human Differential protein profiling in renal-cell carcinoma. 15108329 2004
Conventional (Clear Cell) Renal Cell Carcinoma
0.380 Biomarker disease BEFREE Thus, combining our results with data published previously, it appears that promoter methylation occurs frequently (> or =20% of primary tumours) at CASP8, SLIT2 and RASSF1A in Wilms' tumour and at RASSF1A, TIMP3, DAPK, SLIT2, MT1G and GSTP1 in RCC. 14555992 2003
Conventional (Clear Cell) Renal Cell Carcinoma
0.380 GeneticVariation disease BEFREE There was also a higher risk of RCC for subjects with the CYP1A1 (m) variant genotype combined with any of the following genotypes: GSTT1 (+) "active" [odds ratio (OR), 2.3; 95% CI, 1.2-4.5], GSTP1 (m) variant (OR, 2.4; 95% CI, 1.0-5.4), or NAT2 (-) "slow acetylator" (OR, 2.5; 95% CI, 1.1-5.5). 10383153 1999