GSTP1, glutathione S-transferase pi 1, 2950

N. diseases: 610; N. variants: 18
Disease: Glucocorticoid-remediable aldosteronism ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1260386
Disease: Glucocorticoid-remediable aldosteronism
Glucocorticoid-remediable aldosteronism 		0.010 Biomarker disease BEFREE The dissociation constant of the heterocomplex is K(d)=0.3 μM; however the binding affinity strongly decreases when the active site of GSTP1-1 is occupied by the substrate GSH (K(d)≥2.6 μM) or is inactivated by oxidation (Kd=1.7 μM). 24457959 2014