SENP1, SUMO specific peptidase 1, 29843

N. diseases: 79; N. variants: 5
Disease: Prostate carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.090 AlteredExpression disease BEFREE The expression of SENP1 mRNA was significantly increased in human prostatic carcinoma cell lines after exposure to hypoxia, accompanied by the up-regulation of HIF1α. 30745829 2019
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.090 AlteredExpression disease BEFREE SENP1, a member of this family, is highly expressed and plays oncogenic roles in diverse cancers including prostate cancer. 29705808 2018
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.090 Biomarker disease BEFREE SENP1 regulates PTEN stability to dictate prostate cancer development. 27852060 2017
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.090 Biomarker disease BEFREE In the current study we analyzed prevalence and prognostic impact of the de-SUMOylation enzyme SENP1 in prostate cancer. 26202067 2015
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.090 AlteredExpression disease BEFREE Here we found that low expression of miR-145 was correlated with high expression of SENP1 in PCa cell line PC-3. 25645686 2015
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.090 Biomarker disease BEFREE All these results show the contribution of SENP1 to the progression of prostate cancer, and suggest that SENP1 may be a prognostic marker and a therapeutic target for metastasis in prostate cancer patients. 22733136 2013
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.090 Biomarker disease BEFREE Positive SENP1 immunostaining in the CaP, PIN, and normal prostate tissue samples were 76.5%, 57.9%, and 4.2%, respectively. 23089540 2013
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.090 Biomarker disease BEFREE SUMO-specific protease 1 (SENP1) was thought to be a potential marker and therapeutical target of PCa. 22666381 2012
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.090 AlteredExpression disease BEFREE Here, we show that SENP1 (sentrin/SUMO-specific protease 1) is highly expressed in human prostate cancer specimens and correlates with hypoxia-inducing factor 1alpha (HIF1alpha) expression. 20551310 2010