|
Asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
CLC/Gal-10 and MBP-1 may be useful biomarkers for differentiation of eosinophilic airway inflammation in asthma.
|
31157540 |
2019 |
|
Mycoses
|
0.010 |
AlteredExpression
|
group |
BEFREE |
This review focuses on a family of fungal transcription factors (Swi4/Mbp1, APSES, Xbp1, Bqt4) derived from the lateral gene transfer of a KilA-N domain commonly found in prokaryotic and eukaryotic DNA viruses.
|
31600629 |
2019 |
|
Pulmonary Thromboembolisms
|
0.010 |
Biomarker
|
disease |
BEFREE |
We aimed to investigate if fibulin-4 and -5 can be used as a biomarker for pulmonary thromboembolism (PTE).
|
30632874 |
2019 |
|
Acute infectious disease
|
0.010 |
Biomarker
|
group |
BEFREE |
Here, we investigated the degranulation patterns, including the cellular mechanisms of major basic protein-1 (MBP-1) release, from inflammatory eosinophils in a mouse model of <i>S. mansoni</i> infection (acute phase).
|
30619361 |
2018 |
|
Aneurysm of ascending aorta
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Ascending Aortic Aneurysm in a Child With Fibulin-4 Deficiency.
|
29362193 |
2018 |
|
Abnormality of cardiovascular system morphology
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Mice lacking expression of the elastic fiber genes elastin ( Eln<sup>-/-</sup>), fibulin-4 ( Efemp2<sup>-/-</sup>), or lysyl oxidase ( Lox<sup>-/-</sup>) die at birth with severe cardiovascular malformations.
|
30312140 |
2018 |
|
Osteosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, our findings demonstrate that fibulin-4 is a promoter of osteosarcoma development and progression, and suggest a novel therapeutic target for future studies.
|
28339091 |
2017 |
|
Cardiovascular Abnormalities
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Homozygous or compound heterozygous mutations in fibulin-4 (<i>FBLN4</i>) lead to autosomal recessive cutis laxa type 1B (ARCL1B), a multisystem disorder characterized by significant cardiovascular abnormalities, including abnormal elastin assembly, arterial tortuosity, and aortic aneurysms.
|
28508064 |
2017 |
|
Osteosarcoma of bone
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, our findings demonstrate that fibulin-4 is a promoter of osteosarcoma development and progression, and suggest a novel therapeutic target for future studies.
|
28339091 |
2017 |
|
Childhood Osteosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, our findings demonstrate that fibulin-4 is a promoter of osteosarcoma development and progression, and suggest a novel therapeutic target for future studies.
|
28339091 |
2017 |
|
Ovarian Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, no information has been available to date regarding the function of fibulin-4 in ovarian carcinoma progression.
|
25885889 |
2015 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Fibulin-4 overexpression was significantly associated with advanced stage, low differentiation, lymph node metastasis and poor prognosis in patients with ovarian cancer.
|
25885889 |
2015 |
|
ovarian neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study shows that fibulin-4 may serve as a new prognostic factor and as a potential therapeutic target for patients with ovarian cancer in the future.
|
25885889 |
2015 |
|
Malignant neoplasm of ovary
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, no information has been available to date regarding the function of fibulin-4 in ovarian carcinoma progression.
|
25885889 |
2015 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, no information has been available to date regarding the function of fibulin-4 in ovarian carcinoma progression.
|
25885889 |
2015 |
|
Malignant tumor of cervix
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Fibulin-4 overexpression and high serum levels were significantly associated with advanced stage, low differentiation, lymph node metastasis, and poor prognosis in patients with cervical cancer.
|
24737201 |
2014 |
|
Vascular Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
FBLN4-associated vasculopathy is a highly lethal disease characterized by severe aneurysmal dilatation of thoracic aorta, its branches and pulmonary arteries with stenoses at typical locations.
|
24838734 |
2014 |
|
Cervical Intraepithelial Neoplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Serum fibulin-4 levels in patients with CIN and cervical carcinoma were measured by enzyme-linked immunosorbent assay.
|
24737201 |
2014 |
|
Cerebral Vasospasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Baroreflex failure, sympathetic storm, and cerebral vasospasm in fibulin-4 cutis laxa.
|
24733866 |
2014 |
|
Cervix carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Fibulin-4 overexpression and high serum levels were significantly associated with advanced stage, low differentiation, lymph node metastasis, and poor prognosis in patients with cervical cancer.
|
24737201 |
2014 |
|
Dissection of aorta
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Decreased expression of fibulin-4 in aortic wall of aortic dissection.
|
23518852 |
2014 |
|
Ascending aortic dissection
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
In conclusion, in aortic wall of ascending aortic dissection, the expression of fibulin-4 protein decreased and the expression of fibulin-4 mRNA was abnormal.
|
23518852 |
2014 |
|
cervical cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Fibulin-4 overexpression and high serum levels were significantly associated with advanced stage, low differentiation, lymph node metastasis, and poor prognosis in patients with cervical cancer.
|
24737201 |
2014 |
|
Mesothelioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here we report that AQP1 is overexpressed in epithelioid mesothelioma and identify TRIP6 and EFEMP2 as candidate genes for further investigation in mesothelioma.
|
23313295 |
2013 |
|
Epithelioid mesothelioma, malignant
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here we report that AQP1 is overexpressed in epithelioid mesothelioma and identify TRIP6 and EFEMP2 as candidate genes for further investigation in mesothelioma.
|
23313295 |
2013 |