TLX3, T cell leukemia homeobox 3, 30012

N. diseases: 34; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.020 GeneticVariation phenotype BEFREE Somatically acquired mutations in <i>PHF6</i> (<i>plant homeodomain finger 6</i>) frequently occur in hematopoietic malignancies and often coincide with ectopic expression of <i>TLX3.</i> However, there is no functional evidence to demonstrate whether these mutations contribute to tumorigenesis. 30755422 2019
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.020 GeneticVariation phenotype BEFREE Association with other oncogene expression (TAL1, HOXAs, or TLX3/HOX11L2), NOTCH1 activating mutations, and/or CDKN2A/p16/ARF deletion, showed that cyclin D2 dysregulation could contribute to multi-event oncogenesis in various T-ALL groups. 16270038 2006