Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The stroma cells represent the neoplastic population of the tumor and are characterized by the H3F3A mutation G34W.
|
31015476 |
2019 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The presence of TERT promoter mutation, H3F3A mutation and EGFR amplification showed negative prognostic impacts in this tumor entity.
|
30298540 |
2019 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Since heterozygous H3F3A c. 103G>T (p. Gly34Trp) mutation was detected not only in the biopsy sample from the primary site with typical GCTB and high-grade sarcoma components but also in the resected material from the metastatic site with only pure high-grade sarcoma component, the tumor was considered originally derived from conventional GCTB and acquire malignant transformation to high-grade sarcoma.
|
29970305 |
2018 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
FoxG1-positive nuclei were significantly reduced in IDH and H3F3A K27-mutant tumours, whereas Olig-2-positive nuclei were significantly reduced in IDH-wild-type and H3F3A G34-mutant tumours.
|
29053887 |
2018 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
After the discovery of RANKL, the concept of GCTB as a tumor of RANKL-expressing stromal cells was established, and comprehensive exosome studies finally disclosed the causative single-point mutation at histone H3.3 (H3F3A) in stromal cells.
|
29356963 |
2018 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
None of the tumors harbored H3F3A mutation.
|
29532523 |
2018 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We demonstrate the feasibility of two strategies to detect H3 mutations in CSF-derived tumor DNA from children with brain tumors (n = 11) via either targeted Sanger sequencing of H3F3A and HIST1H3B, or H3F3A c.83 A > T detection via nested PCR with mutation-specific primers.
|
28416018 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A diagnostic algorithm based on IDH, TERT, ATRX, H3F3A, and 1p19q co-deletion status resulted in a consistent molecular classification with only 14 (13%) marker-negative tumors.
|
28823044 |
2017 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Patients with H3F3A-mutated tumors (13.8 months overall survival) had much worse prognoses than those with IDH1-mutated (54.9 months, p=0.001) or H3F3A-IDH1 co-wildtype tumors (38.4 months, p=0.001).
|
29137285 |
2017 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Yet, the reliability of ATRX in predicting isocitrate dehydrogenase (IDH) and H3 histone, family 3A (H3F3A) mutations in gliomas, is unclear.We analysed the ATRX expression status by immunohistochemistry, in a large series of 1064 gliomas and analysed the results in correlation to IDH, H3F3A and loss of heterozygosity (LOH) 1p/19q status in these tumors.
|
27311324 |
2016 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Molecular diagnosis of tumor tissue obtained at first and second surgeries revealed H3F3A K27M mutation in both primary and secondary specimens.
|
27392443 |
2016 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our results show that H3F3A and H3F3B mutation analysis appears to be a highly specific, although less sensitive, diagnostic tool for the distinction of GCTB and chondroblastoma from other giant cell-containing tumors.
|
26457357 |
2015 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We only identified H3F3A K27M in 2 of 34 cases (5.9%), with both tumors located in the posterior fossa.
|
25231549 |
2015 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We identified an increased number of iCNA in older children compared to infants, and increased iCNA in H3F3A K27M mutant tumours compared to G34R/V and wild-type.
|
24548782 |
2014 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Because H3F3A K27M mutations occur exclusively in pediatric diffuse high-grade astrocytomas, analysis of codon 27 mutational status could be useful in the differential diagnosis of these neoplasms.
|
23429371 |
2013 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In the context of previously reported H3F3A mutations encoding p.Lys27Met and p.Gly34Arg or p.Gly34Val alterations in childhood brain tumors, a remarkable picture of tumor type specificity for histone H3.3 driver alterations emerges, indicating that histone H3.3 residues, mutations and genes have distinct functions.
|
24162739 |
2013 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Evaluation of histone 3 lysine 27 trimethylation (H3K27me3) and enhancer of Zest 2 (EZH2) in pediatric glial and glioneuronal tumors shows decreased H3K27me3 in H3F3A K27M mutant glioblastomas.
|
23414300 |
2013 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Furthermore, SETD2 mutations were mutually exclusive with H3F3A mutations in HGGs (P = 0.0492) while they partly overlapped with IDH1 mutations (4/14), and SETD2-mutant tumors were found exclusively in the cerebral hemispheres (P = 0.0055).
|
23417712 |
2013 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Recurrent mutations in H3F3A, which encodes the replication-independent histone 3 variant H3.3, were observed in 31% of tumours, and led to amino acid substitutions at two critical positions within the histone tail (K27M, G34R/G34V) involved in key regulatory post-translational modifications.
|
22286061 |
2012 |