|
Abdominal Pain
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Abnormal bone structure
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Abnormal hemoglobin finding
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Abnormality of metabolism/homeostasis
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Abnormality of the dentition
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Abnormality of the hypothalamus-pituitary axis
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Abnormality of the skeletal system
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Abnormality of the spleen
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Abnormality of the thorax
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Achromatopsia
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Acute Erythroblastic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CAAT/enhancer-binding proteins are involved in beta-globin gene expression and are differentially expressed in murine erythroleukemia and K562 cells.
|
8663270 |
1996 |
|
Acute Erythroblastic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, beta-globin gene expression has been evaluated in human erythroleukemia cells, K562 cells, and, although stable transformants with integrated beta-globin genes have been obtained, none of these transformants expressed the added beta-globin genes.
|
2990298 |
1985 |
|
Acute Erythroblastic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To resolve the apparent paradox of hypermethylated LTRs possessing transcriptional activities, we studied the ERV-9 LTR retrotransposon located at the 5' border of the transcriptionally active β-globin gene locus in human erythroid progenitor and erythroleukemia K562 cells.
|
28165867 |
2017 |
|
Acute Erythroblastic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These recombinant virions were used to infect a human erythroleukemia cell line which normally does not express the beta-globin gene (K562), or a human nasopharyngeal carcinoma cell line (KB).
|
8646553 |
1996 |
|
Acute Erythroblastic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression from a virally transferred gamma- or beta-globin gene exceeded endogenous gamma- or beta-globin expression by a factor of 6 or more in the human erythroleukemia line KMOE, in which the endogenous globin genes are weakly inducible.
|
1693523 |
1990 |
|
Acute Erythroblastic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Controls with the beta-globin gene, which is constitutively nonexpressed in Namalva-S cells but upon induction is highly expressed in murine erythroleukemia cells, completely confirmed the conclusion we had made for the intranuclear localization of c-myc.
|
1379916 |
1992 |
|
Acute Erythroblastic Leukemia
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Using chromatin immunoprecipitation assays, we show that PIAS3 preferentially occupies the β-globin promoter in undifferentiated murine erythroleukemia cells.
|
25713074 |
2015 |
|
Acute Erythroblastic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Trans acting regulation of beta globin gene expression in erythroleukemia (K562) cells.
|
2991858 |
1985 |
|
Acute Erythroblastic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A cosmid construct containing extensive human gamma- and beta-globin gene promoter and structural sequences as well as upstream control sequences also exhibits higher levels of globin gene transcription in K562 NE than in HeLa NE.
|
8353292 |
1993 |
|
Acute Erythroblastic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Activation of the beta-globin promoter by the locus control region correlates with binding of a novel factor to the CAAT box in murine erythroleukemia cells but not in K562 cells.
|
8413287 |
1993 |
|
Acute Erythroblastic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Erythroleukemia (K562) cells contain a functional beta-globin gene.
|
6595498 |
1984 |
|
Acute Erythroblastic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Human alpha- and beta-globin gene transcription in mouse erythroleukaemia cells.
|
6151696 |
1984 |
|
Acute Erythroblastic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
To determine the critical cis-acting elements, hybrid genes containing elements of the gamma and beta globin genes were transfected into K562 cells, a human erythroleukemia line.
|
2735651 |
1989 |
|
Acute Erythroblastic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Introduction of a virus containing the beta-globin gene with introns into murine erythroleukemia cells resulted in inducible expression of human beta-globin RNA and protein, while the viruses containing the minigene were inactive.
|
3288863 |
1988 |
|
Acute Erythroblastic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Both proteins were expressed in and secreted by murine erythroleukemia cells under the control of the human beta-globin promoter placed down-stream from the human globin locus control region.
|
7530072 |
1994 |