|
Heart Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
MHb levels of 70% are generally lethal, but the existence of underlying anemia, acidosis, respiratory compromise, and cardiac disease may exacerbate the toxicity of MHb.
|
30293223 |
2019 |
|
Iron-Refractory Iron Deficiency Anemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
In a study ambispective comprising 1623 patients, 153 subjects showed an abnormal hemoglobin and 1470 with hypochromic and microcytic anemia, and of these 1470, 23 patients were studied for simultaneously α-thalassemias and structural hemoglobinopathies.
|
31025160 |
2019 |
|
Blanching of skin
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Moreover, it produced an elevation in methemoglobin levels and skin blanching.
|
30587535 |
2019 |
|
Anemia, Hemolytic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Sickle cell disease (SCD) is an autosomal recessive disorder that results in hemolytic anemia related to abnormal hemoglobin and erythrocyte levels.
|
29309293 |
2018 |
|
Malignant neoplasm of vulva
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A 47-year-old female with medical history of vulvar cancer and HIV undergoing chemoradiation was sent by the oncology clinic to the emergency department for worsening dyspnea, fatigue, hypoxia to 78% on room air, and gradual onset of cyanosis over the past week.A methemoglobin (MetHb) level was 49%.
|
27754990 |
2018 |
|
CARCINOMA OF VULVA
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A 47-year-old female with medical history of vulvar cancer and HIV undergoing chemoradiation was sent by the oncology clinic to the emergency department for worsening dyspnea, fatigue, hypoxia to 78% on room air, and gradual onset of cyanosis over the past week.A methemoglobin (MetHb) level was 49%.
|
27754990 |
2018 |
|
Triple Negative Breast Neoplasms
|
0.010 |
Biomarker
|
disease |
BEFREE |
Although BCL11A was shown to suppress γ-globin and p21 and to induce MDM2 expression in the hematopoietic system, its downstream targets in TNBC are still unclear.
|
29263092 |
2018 |
|
Triple-Negative Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Although BCL11A was shown to suppress γ-globin and p21 and to induce MDM2 expression in the hematopoietic system, its downstream targets in TNBC are still unclear.
|
29263092 |
2018 |
|
Coronary heart disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Symptoms occur at varying methemoglobin levels and are more severe in patients with pre-existing coronary disease or chronic lung disease.
|
28699887 |
2017 |
|
Immunologic Deficiency Syndromes
|
0.010 |
Biomarker
|
group |
BEFREE |
We developed a double gene lentiviral vector encoding both human γ-globin and NA10HD, which was used to transduce human peripheral blood CD34<sup>+</sup> cells and increased engraftment 2- to 2.5-fold at 15 weeks post-transplantation in immunodeficient mice.
|
28190779 |
2017 |
|
Intravascular hemolysis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In these patients, excessive intravascular hemolysis saturates scavenger mechanisms resulting in free hemoglobin in plasma that irreversibly reacts with nitric oxide to form nitrate and methemoglobin, leading to arterial thrombosis.
|
28622911 |
2017 |
|
HPFH deletion type
|
0.010 |
Biomarker
|
disease |
BEFREE |
Hereditary persistence of fetal hemoglobin deletion type-2 (HPFH-2) and Sicilian-δβ-thalassemia are conditions described as large deletions of the human β-like globin cluster, with absent β-globin chains and a compensatory variable increase in γ-globin.
|
27591578 |
2017 |
|
Chronic lung disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Symptoms occur at varying methemoglobin levels and are more severe in patients with pre-existing coronary disease or chronic lung disease.
|
28699887 |
2017 |
|
SPONDYLOCARPOTARSAL SYNOSTOSIS SYNDROME
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Sickle cell trait (SCT) places individuals at risk of passing an abnormal hemoglobin gene to biological children and is associated with rare but serious complications.
|
27550467 |
2017 |
|
Coronary Artery Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Symptoms occur at varying methemoglobin levels and are more severe in patients with pre-existing coronary disease or chronic lung disease.
|
28699887 |
2017 |
|
Central cyanosis
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Although rare, congenital methaemoglobin aemia should be considered in the differential in a preterm with central cyanosis and investigated with genetic testing for γ globin chain mutations if other laboratory tests are non-conclusive.
|
26969357 |
2016 |
|
Metabolic Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Given that increased expression of γ-globin leads to increased levels of fetal hemoglobin which confers protection against malaria, we hypothesize that evolution in Africa of protection against malaria may have occurred at the cost of increased serum uric acid levels, contributing to the high rates of hyperuricemia and associated cardio-metabolic disorders observed in African Americans.
|
26686224 |
2015 |
|
Hyperuricemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Given that increased expression of γ-globin leads to increased levels of fetal hemoglobin which confers protection against malaria, we hypothesize that evolution in Africa of protection against malaria may have occurred at the cost of increased serum uric acid levels, contributing to the high rates of hyperuricemia and associated cardio-metabolic disorders observed in African Americans.
|
26686224 |
2015 |
|
Fanconi Anemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
In our study of 97 patients with an IBMFS, increased Hb F was associated with young age, male gender, anaemia, high erythropoietin levels, and alternative alleles in Xmn1-HBG2 [adjusted P = 0·04 for the total group, driven by Fanconi anaemia (P = 0·02) and dyskeratosis congenita (P = 0·09)].
|
23713742 |
2013 |
|
B-Cell Lymphomas
|
0.010 |
AlteredExpression
|
group |
BEFREE |
B-cell lymphoma 11A (BCL11A) downregulation in human primary adult erythroid progenitors results in elevated expression of fetal γ-globin.
|
23361909 |
2013 |
|
Dyskeratosis Congenita
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In our study of 97 patients with an IBMFS, increased Hb F was associated with young age, male gender, anaemia, high erythropoietin levels, and alternative alleles in Xmn1-HBG2 [adjusted P = 0·04 for the total group, driven by Fanconi anaemia (P = 0·02) and dyskeratosis congenita (P = 0·09)].
|
23713742 |
2013 |
|
NADH cytochrome B5 reductase deficiency
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Neonatal cyanosis in healthy newborns can be associated either with methemoglobin due to cytochrome b5 reductase deficiency or to M-hemoglobin, a group of hemoglobin variants resulting from mutations in the globin chain genes.
|
22935660 |
2013 |
|
Alzheimer's Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Hemoglobin binding to A beta and HBG2 SNP association suggest a role in Alzheimer's disease.
|
17157413 |
2008 |
|
Hereditary gingival fibromatosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
However, gene expression profile analysis revealed reduced expression of hemoglobin beta (HBB), hemoglobin delta (HBD), hemoglobin gamma A (HBG1) and hemoglobin gamma G (HBG2) genes at disease locus in HGF patients.
|
17075716 |
2007 |
|
Red blood cell disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
Newly identified modifiers of alpha- and gamma-globin synthesis and insights into the mechanisms of globin regulation provide the tools for potential new approaches to treating this and other red blood cell disorders.
|
15931385 |
2005 |