Liposarcoma, Dedifferentiated
|
0.010 |
Biomarker
|
disease |
BEFREE |
<i>In vitro</i>, treatment of DDLPS cell lines with the HDAC inhibitors MI-192 (HDAC2/3 inhibitor) or romidepsin (HDAC1/2 inhibitor) reduced <i>MDM2</i> expression and induced apoptosis.
|
31620242 |
2019 |
Tumor Progression
|
0.090 |
AlteredExpression
|
phenotype |
BEFREE |
(1)H-HRMAS technology revealed metabolomically distinct groups according to the expression of HDAC1, HDAC4 and SIRT1, suggesting that these genes may play an important role in regulating brain tumorigenesis and cancer progression.
|
25791281 |
2015 |
Malignant neoplasm of lung
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
17beta-Estradiol decreased DNMT1 and HDAC1 protein expressions and their binding activity on MGMT promoter, and this may partially contribute to the gender difference of MGMT hypermethylation in lung cancer.
|
19596925 |
2009 |
Carcinoma of lung
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
17beta-Estradiol decreased DNMT1 and HDAC1 protein expressions and their binding activity on MGMT promoter, and this may partially contribute to the gender difference of MGMT hypermethylation in lung cancer.
|
19596925 |
2009 |
Primary malignant neoplasm of lung
|
0.090 |
PosttranslationalModification
|
disease |
BEFREE |
17beta-Estradiol decreased DNMT1 and HDAC1 protein expressions and their binding activity on MGMT promoter, and this may partially contribute to the gender difference of MGMT hypermethylation in lung cancer.
|
19596925 |
2009 |
melanoma
|
0.030 |
Biomarker
|
disease |
LHGDN |
Melanoma senescence: HDAC1 in focus.
|
17850504 |
2007 |
Hepatitis B
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Hepatitis B virus X protein induces the expression of MTA1 and HDAC1, which enhances hypoxia signaling in hepatocellular carcinoma cells.
|
18264140 |
2008 |
Hereditary pancreatitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
HP infection could promote HDAC1 and HDAC4 expression as determined by Western blotting.
|
28700998 |
2017 |
Hyperplastic Polyp
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
HP infection could promote HDAC1 and HDAC4 expression as determined by Western blotting.
|
28700998 |
2017 |
Osteosarcoma of bone
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Bone cancer caused significantly increased expression of HDAC1 in spinal microglia and neurons, with HDAC2 markedly increased in spinal astrocytes, which were accompanied by the upregulation of MAPK pathways and the activation of microglia and astrocytes in the SDH.
|
29096654 |
2017 |
Malignant Bone Neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Bone cancer caused significantly increased expression of HDAC1 in spinal microglia and neurons, with HDAC2 markedly increased in spinal astrocytes, which were accompanied by the upregulation of MAPK pathways and the activation of microglia and astrocytes in the SDH.
|
29096654 |
2017 |
Carcinoma of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Histone deacetylase 1 represses the small GTPase RhoB expression in human nonsmall lung carcinoma cell line.
|
13679859 |
2003 |
Malignant neoplasm of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
HDAC1/GAPDH mRNA levels were significantly higher in T3 or T4 lung carcinoma (54.326 +/- 127.018) than in T1 or T2 lung cancers (14.790 +/- 48.670, P = 0.1601).
|
15474665 |
2004 |
Acute lymphocytic leukemia
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
HDAC1 and HDAC4 showed high expression in T-ALL and HDAC5 was highly expressed in B-lineage ALL.
|
20636436 |
2010 |
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Histone deacetylase 1 (HDAC1) and metastasis-associated protein 1 (MTA1) form the nucleosome remodeling and histone deacetylation (NuRD) complex and may possibly play a central role in cancer development.
|
21617866 |
2011 |
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Histone deacetylase 1 (HDAC1) and metastasis-associated protein 1 (MTA1) form the nucleosome remodeling and histone deacetylation (NuRD) complex and may possibly play a central role in cancer development.
|
21617866 |
2011 |
Malignant neoplasm of stomach
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Histone deacetylase 1 expression in gastric cancer.
|
21725604 |
2011 |
Stomach Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Histone deacetylase 1 expression in gastric cancer.
|
21725604 |
2011 |
Asthma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
HDAC1 expression was increased in patients with severe asthma compared with healthy volunteers.
|
22156779 |
2012 |
Endometriosis
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
HDAC1 and HDAC2 are differentially expressed in endometriosis.
|
22344732 |
2012 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
HDAC1-3 were up-regulated in HCC samples from patients.
|
22641068 |
2012 |
Idiopathic pulmonary arterial hypertension
|
0.300 |
Biomarker
|
disease |
CTD_human |
HDAC1 and HDAC5 protein levels were elevated in lungs from human idiopathic pulmonary arterial hypertension and in lungs and right ventricles from rats exposed to hypoxia.
|
22711276 |
2012 |
Endometrioma
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Histone deacetylase-1 target mRNAs that were up-regulated by valproic acid (VPA) treatment in endometriotic cyst stromal cells (ECSCs) were identified by a global mRNA microarray technique.
|
23833041 |
2013 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
HDAC-I has both anti-tumor activity and radiation sensitization activity.
|
23888958 |
2014 |
Leukocyte adhesion deficiency type 1
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
HDAC1/4 levels in docetaxel-insensitive human LAD tissues, inversely correlated with miR-200b, were upregulated compared with docetaxel-sensitive tissues.
|
24830600 |
2014 |