HDAC1, histone deacetylase 1, 3065

N. diseases: 277; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0205824
Disease: Liposarcoma, Dedifferentiated
Liposarcoma, Dedifferentiated
0.010 Biomarker disease BEFREE <i>In vitro</i>, treatment of DDLPS cell lines with the HDAC inhibitors MI-192 (HDAC2/3 inhibitor) or romidepsin (HDAC1/2 inhibitor) reduced <i>MDM2</i> expression and induced apoptosis. 31620242 2019
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.090 AlteredExpression phenotype BEFREE (1)H-HRMAS technology revealed metabolomically distinct groups according to the expression of HDAC1, HDAC4 and SIRT1, suggesting that these genes may play an important role in regulating brain tumorigenesis and cancer progression. 25791281 2015
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.100 PosttranslationalModification disease BEFREE 17beta-Estradiol decreased DNMT1 and HDAC1 protein expressions and their binding activity on MGMT promoter, and this may partially contribute to the gender difference of MGMT hypermethylation in lung cancer. 19596925 2009
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.100 PosttranslationalModification disease BEFREE 17beta-Estradiol decreased DNMT1 and HDAC1 protein expressions and their binding activity on MGMT promoter, and this may partially contribute to the gender difference of MGMT hypermethylation in lung cancer. 19596925 2009
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.090 PosttranslationalModification disease BEFREE 17beta-Estradiol decreased DNMT1 and HDAC1 protein expressions and their binding activity on MGMT promoter, and this may partially contribute to the gender difference of MGMT hypermethylation in lung cancer. 19596925 2009
CUI: C0025202
Disease: melanoma
melanoma
0.030 Biomarker disease LHGDN Melanoma senescence: HDAC1 in focus. 17850504 2007
CUI: C0019163
Disease: Hepatitis B
Hepatitis B
0.020 AlteredExpression disease BEFREE Hepatitis B virus X protein induces the expression of MTA1 and HDAC1, which enhances hypoxia signaling in hepatocellular carcinoma cells. 18264140 2008
CUI: C0238339
Disease: Hereditary pancreatitis
Hereditary pancreatitis
0.010 AlteredExpression disease BEFREE HP infection could promote HDAC1 and HDAC4 expression as determined by Western blotting. 28700998 2017
CUI: C0333983
Disease: Hyperplastic Polyp
Hyperplastic Polyp
0.010 AlteredExpression disease BEFREE HP infection could promote HDAC1 and HDAC4 expression as determined by Western blotting. 28700998 2017
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.030 AlteredExpression disease BEFREE Bone cancer caused significantly increased expression of HDAC1 in spinal microglia and neurons, with HDAC2 markedly increased in spinal astrocytes, which were accompanied by the upregulation of MAPK pathways and the activation of microglia and astrocytes in the SDH. 29096654 2017
CUI: C0279530
Disease: Malignant Bone Neoplasm
Malignant Bone Neoplasm
0.010 AlteredExpression disease BEFREE Bone cancer caused significantly increased expression of HDAC1 in spinal microglia and neurons, with HDAC2 markedly increased in spinal astrocytes, which were accompanied by the upregulation of MAPK pathways and the activation of microglia and astrocytes in the SDH. 29096654 2017
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.100 AlteredExpression disease BEFREE Histone deacetylase 1 represses the small GTPase RhoB expression in human nonsmall lung carcinoma cell line. 13679859 2003
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.100 AlteredExpression disease BEFREE HDAC1/GAPDH mRNA levels were significantly higher in T3 or T4 lung carcinoma (54.326 +/- 127.018) than in T1 or T2 lung cancers (14.790 +/- 48.670, P = 0.1601). 15474665 2004
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.030 AlteredExpression disease BEFREE HDAC1 and HDAC4 showed high expression in T-ALL and HDAC5 was highly expressed in B-lineage ALL. 20636436 2010
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 Biomarker group BEFREE Histone deacetylase 1 (HDAC1) and metastasis-associated protein 1 (MTA1) form the nucleosome remodeling and histone deacetylation (NuRD) complex and may possibly play a central role in cancer development. 21617866 2011
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker group BEFREE Histone deacetylase 1 (HDAC1) and metastasis-associated protein 1 (MTA1) form the nucleosome remodeling and histone deacetylation (NuRD) complex and may possibly play a central role in cancer development. 21617866 2011
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.100 AlteredExpression disease BEFREE Histone deacetylase 1 expression in gastric cancer. 21725604 2011
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 AlteredExpression disease BEFREE Histone deacetylase 1 expression in gastric cancer. 21725604 2011
CUI: C0004096
Disease: Asthma
Asthma
0.050 AlteredExpression disease BEFREE HDAC1 expression was increased in patients with severe asthma compared with healthy volunteers. 22156779 2012
CUI: C0014175
Disease: Endometriosis
Endometriosis
0.310 AlteredExpression disease BEFREE HDAC1 and HDAC2 are differentially expressed in endometriosis. 22344732 2012
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 AlteredExpression disease BEFREE HDAC1-3 were up-regulated in HCC samples from patients. 22641068 2012
Idiopathic pulmonary arterial hypertension
0.300 Biomarker disease CTD_human HDAC1 and HDAC5 protein levels were elevated in lungs from human idiopathic pulmonary arterial hypertension and in lungs and right ventricles from rats exposed to hypoxia. 22711276 2012
CUI: C0269102
Disease: Endometrioma
Endometrioma
0.310 AlteredExpression disease BEFREE Histone deacetylase-1 target mRNAs that were up-regulated by valproic acid (VPA) treatment in endometriotic cyst stromal cells (ECSCs) were identified by a global mRNA microarray technique. 23833041 2013
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE HDAC-I has both anti-tumor activity and radiation sensitization activity. 23888958 2014
Leukocyte adhesion deficiency type 1
0.020 AlteredExpression disease BEFREE HDAC1/4 levels in docetaxel-insensitive human LAD tissues, inversely correlated with miR-200b, were upregulated compared with docetaxel-sensitive tissues. 24830600 2014