HDAC1, histone deacetylase 1, 3065

N. diseases: 277; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 GeneticVariation phenotype BEFREE In this study, we aimed to investigate the role of histone deacetylase 1 (HDAC1), which is an epigenetic mechanism on distant metastasis of PDAC. 29917299 2018
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.100 GeneticVariation disease BEFREE TMPRSS2 fusions with oncogenic ETS factors in prostate cancer involve unbalanced genomic rearrangements and are associated with HDAC1 and epigenetic reprogramming. 17079440 2006
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.100 GeneticVariation disease BEFREE This is the first report demonstrating that CXXC sequence containing MBD1 is overexpressed and can be the major factor of hypermethylated chromatin segments through HDAC1/2 translocation and histone deacetylation in human prostate cancer. 12646234 2003
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 GeneticVariation disease BEFREE This is the first report demonstrating that CXXC sequence containing MBD1 is overexpressed and can be the major factor of hypermethylated chromatin segments through HDAC1/2 translocation and histone deacetylation in human prostate cancer. 12646234 2003
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 GeneticVariation disease BEFREE TMPRSS2 fusions with oncogenic ETS factors in prostate cancer involve unbalanced genomic rearrangements and are associated with HDAC1 and epigenetic reprogramming. 17079440 2006
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 GeneticVariation phenotype BEFREE β-arr1-β-catenin interaction controls β-catenin target gene expressions, such as ET-1, Axin 2, Matrix metalloproteinase 2, and Cyclin D1, by promoting histone deacetylase 1 (HDAC1) dissociation and the recruitment of p300 acetyltransferase on these promoter genes, resulting in enhanced H3 and H4 histone acetylation, and gene transcription, required for cell migration, invasion and epithelial-to-mesenchymal transition. 23208497 2013
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 GeneticVariation disease BEFREE E-cadherin level is highly up-regulated in HDAC1 O-GlcNAc mutant-treated liver cancer cells, which inhibit the occurrence and development of HCC. 27060025 2016
CUI: C0004096
Disease: Asthma
Asthma
0.050 GeneticVariation disease BEFREE The present study demonstrated that rs1741981 in HDAC1 was significantly associated with the response to corticosteroid treatment in asthmatics. 24307847 2013
CUI: C0233794
Disease: Memory impairment
Memory impairment
0.030 GeneticVariation phenotype BEFREE We tested zinc-dependent HDACs using RNAi in Drosophila melanogaster and found memory deficits with RPD3 and HDAC6. 28178513 2017
CUI: C0002736
Disease: Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis
0.020 GeneticVariation disease BEFREE A common familial ALS-associated FUS mutation (FUS-R521C) is revealed to prefer to cooperate with RBM45 than HDAC1. 29140459 2017
CUI: C0235964
Disease: Renal dysgenesis
Renal dysgenesis
0.010 GeneticVariation disease BEFREE Finally, although HDAC1/2-deficient NPCs and RVs overexpress hyperacetylated p53, <i>Trp53</i> deletion failed to rescue the renal dysgenesis. 29712641 2018
CUI: C0521158
Disease: Recurrent tumor
Recurrent tumor
0.010 GeneticVariation phenotype BEFREE Combination of polymorphisms within the HDAC1 and HDAC3 gene predict tumor recurrence in hepatocellular carcinoma patients that have undergone transplant therapy. 20731616 2010
CUI: C0524910
Disease: Hepatitis C, Chronic
Hepatitis C, Chronic
0.010 GeneticVariation disease BEFREE To identify genetic markers that help optimize the IL-28B prediction of chronic hepatitis C (CHC) sustained virological response (SVR), we evaluated 27 single-nucleotide polymorphisms (SNPs) in HDAC1-11. 23615070 2014
CUI: C1862939
Disease: AMYOTROPHIC LATERAL SCLEROSIS 1
AMYOTROPHIC LATERAL SCLEROSIS 1
0.010 GeneticVariation disease BEFREE Using transgenic mice expressing a common FALS-associated FUS mutation (FUS-R521C mice), we found that mutant FUS proteins formed a stable complex with WT FUS proteins and interfered with the normal interactions between FUS and histone deacetylase 1 (HDAC1). 24509083 2014
Recurrent Dedifferentiated Liposarcoma
0.010 GeneticVariation disease BEFREE While the point mutation rate was modest, integrative analyses and additional screening identified somatic mutations in HDAC1 in 8.3% of DLPS. 22328974 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.360 Biomarker disease BEFREE Our data suggest that HDAC1 inhibition should be considered as a therapeutic approach to treat schizophrenia. 28533418 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.360 Biomarker disease PSYGENET Postmortem brain studies have shown that HDAC1-a lysine deacetylase with broad activity against histones and nonhistone proteins-is frequently expressed at increased levels in prefrontal cortex (PFC) of subjects diagnosed with schizophrenia and related disease. 23664640 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.360 Biomarker disease BEFREE To characterize the contribution of these factors to the developmental perturbation hypothesized to underlie SZ, lentiviral vectors carrying short hairpin RNA interference (shRNAi) for HDAC1 and DAXX were used. 26812044 2016
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.360 Biomarker disease PSYGENET The mRNA expression level of an epigenetically regulated schizophrenia candidate gene GAD67 was strongly and negatively correlated with the mRNA expression levels of HDAC1, HDAC3 and HDAC4 levels. 17961987 2008
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.320 Biomarker disease CTD_human Physical association of HDAC1 and HDAC2 with p63 mediates transcriptional repression and tumor maintenance in squamous cell carcinoma. 21527555 2011
CUI: C0014175
Disease: Endometriosis
Endometriosis
0.310 Biomarker disease CTD_human Nuclear receptor, coregulator signaling, and chromatin remodeling pathways suggest involvement of the epigenome in the steroid hormone response of endometrium and abnormalities in endometriosis. 22138541 2012
CUI: C0269102
Disease: Endometrioma
Endometrioma
0.310 Biomarker disease CTD_human Nuclear receptor, coregulator signaling, and chromatin remodeling pathways suggest involvement of the epigenome in the steroid hormone response of endometrium and abnormalities in endometriosis. 22138541 2012
CUI: C3463824
Disease: MYELODYSPLASTIC SYNDROME
MYELODYSPLASTIC SYNDROME
0.310 Biomarker group CTD_human Apoptotic cells significantly increased in both types of MDS. mRNA and protein levels of HDAC1 and TLR2 were reduced, whereas GATA-1 was increased in both types of MDS. 28963909 2017
CUI: C0018799
Disease: Heart Diseases
Heart Diseases
0.300 Biomarker group CTD_human Transgenic overexpression of Hdac3 in the heart produces increased postnatal cardiac myocyte proliferation but does not induce hypertrophy. 18625706 2008
Familial primary pulmonary hypertension
0.300 Biomarker disease CTD_human Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid. 22711276 2012