Neoplasm Metastasis
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
In this study, we aimed to investigate the role of histone deacetylase 1 (HDAC1), which is an epigenetic mechanism on distant metastasis of PDAC.
|
29917299 |
2018 |
Malignant neoplasm of prostate
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TMPRSS2 fusions with oncogenic ETS factors in prostate cancer involve unbalanced genomic rearrangements and are associated with HDAC1 and epigenetic reprogramming.
|
17079440 |
2006 |
Malignant neoplasm of prostate
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This is the first report demonstrating that CXXC sequence containing MBD1 is overexpressed and can be the major factor of hypermethylated chromatin segments through HDAC1/2 translocation and histone deacetylation in human prostate cancer.
|
12646234 |
2003 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This is the first report demonstrating that CXXC sequence containing MBD1 is overexpressed and can be the major factor of hypermethylated chromatin segments through HDAC1/2 translocation and histone deacetylation in human prostate cancer.
|
12646234 |
2003 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TMPRSS2 fusions with oncogenic ETS factors in prostate cancer involve unbalanced genomic rearrangements and are associated with HDAC1 and epigenetic reprogramming.
|
17079440 |
2006 |
Tumor Cell Invasion
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
β-arr1-β-catenin interaction controls β-catenin target gene expressions, such as ET-1, Axin 2, Matrix metalloproteinase 2, and Cyclin D1, by promoting histone deacetylase 1 (HDAC1) dissociation and the recruitment of p300 acetyltransferase on these promoter genes, resulting in enhanced H3 and H4 histone acetylation, and gene transcription, required for cell migration, invasion and epithelial-to-mesenchymal transition.
|
23208497 |
2013 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
E-cadherin level is highly up-regulated in HDAC1 O-GlcNAc mutant-treated liver cancer cells, which inhibit the occurrence and development of HCC.
|
27060025 |
2016 |
Asthma
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
The present study demonstrated that rs1741981 in HDAC1 was significantly associated with the response to corticosteroid treatment in asthmatics.
|
24307847 |
2013 |
Memory impairment
|
0.030 |
GeneticVariation
|
phenotype |
BEFREE |
We tested zinc-dependent HDACs using RNAi in Drosophila melanogaster and found memory deficits with RPD3 and HDAC6.
|
28178513 |
2017 |
Amyotrophic Lateral Sclerosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
A common familial ALS-associated FUS mutation (FUS-R521C) is revealed to prefer to cooperate with RBM45 than HDAC1.
|
29140459 |
2017 |
Renal dysgenesis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Finally, although HDAC1/2-deficient NPCs and RVs overexpress hyperacetylated p53, <i>Trp53</i> deletion failed to rescue the renal dysgenesis.
|
29712641 |
2018 |
Recurrent tumor
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Combination of polymorphisms within the HDAC1 and HDAC3 gene predict tumor recurrence in hepatocellular carcinoma patients that have undergone transplant therapy.
|
20731616 |
2010 |
Hepatitis C, Chronic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To identify genetic markers that help optimize the IL-28B prediction of chronic hepatitis C (CHC) sustained virological response (SVR), we evaluated 27 single-nucleotide polymorphisms (SNPs) in HDAC1-11.
|
23615070 |
2014 |
AMYOTROPHIC LATERAL SCLEROSIS 1
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Using transgenic mice expressing a common FALS-associated FUS mutation (FUS-R521C mice), we found that mutant FUS proteins formed a stable complex with WT FUS proteins and interfered with the normal interactions between FUS and histone deacetylase 1 (HDAC1).
|
24509083 |
2014 |
Recurrent Dedifferentiated Liposarcoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
While the point mutation rate was modest, integrative analyses and additional screening identified somatic mutations in HDAC1 in 8.3% of DLPS.
|
22328974 |
2011 |
Schizophrenia
|
0.360 |
Biomarker
|
disease |
BEFREE |
Our data suggest that HDAC1 inhibition should be considered as a therapeutic approach to treat schizophrenia.
|
28533418 |
2017 |
Schizophrenia
|
0.360 |
Biomarker
|
disease |
PSYGENET |
Postmortem brain studies have shown that HDAC1-a lysine deacetylase with broad activity against histones and nonhistone proteins-is frequently expressed at increased levels in prefrontal cortex (PFC) of subjects diagnosed with schizophrenia and related disease.
|
23664640 |
2013 |
Schizophrenia
|
0.360 |
Biomarker
|
disease |
BEFREE |
To characterize the contribution of these factors to the developmental perturbation hypothesized to underlie SZ, lentiviral vectors carrying short hairpin RNA interference (shRNAi) for HDAC1 and DAXX were used.
|
26812044 |
2016 |
Schizophrenia
|
0.360 |
Biomarker
|
disease |
PSYGENET |
The mRNA expression level of an epigenetically regulated schizophrenia candidate gene GAD67 was strongly and negatively correlated with the mRNA expression levels of HDAC1, HDAC3 and HDAC4 levels.
|
17961987 |
2008 |
Squamous cell carcinoma
|
0.320 |
Biomarker
|
disease |
CTD_human |
Physical association of HDAC1 and HDAC2 with p63 mediates transcriptional repression and tumor maintenance in squamous cell carcinoma.
|
21527555 |
2011 |
Endometriosis
|
0.310 |
Biomarker
|
disease |
CTD_human |
Nuclear receptor, coregulator signaling, and chromatin remodeling pathways suggest involvement of the epigenome in the steroid hormone response of endometrium and abnormalities in endometriosis.
|
22138541 |
2012 |
Endometrioma
|
0.310 |
Biomarker
|
disease |
CTD_human |
Nuclear receptor, coregulator signaling, and chromatin remodeling pathways suggest involvement of the epigenome in the steroid hormone response of endometrium and abnormalities in endometriosis.
|
22138541 |
2012 |
MYELODYSPLASTIC SYNDROME
|
0.310 |
Biomarker
|
group |
CTD_human |
Apoptotic cells significantly increased in both types of MDS. mRNA and protein levels of HDAC1 and TLR2 were reduced, whereas GATA-1 was increased in both types of MDS.
|
28963909 |
2017 |
Heart Diseases
|
0.300 |
Biomarker
|
group |
CTD_human |
Transgenic overexpression of Hdac3 in the heart produces increased postnatal cardiac myocyte proliferation but does not induce hypertrophy.
|
18625706 |
2008 |
Familial primary pulmonary hypertension
|
0.300 |
Biomarker
|
disease |
CTD_human |
Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid.
|
22711276 |
2012 |