Meckel syndrome type 1
|
0.010 |
Biomarker
|
disease |
BEFREE |
Rescue of HDAC1 in NFAT2-knockdown GSCs partially restored tumor growth and MES phenotype.
|
31400279 |
2020 |
Congenital Abnormality
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Developmental stage-specific depletion of both HDAC1 and HDAC2 in radial glial progenitors results in mispositioning of IPs at the ventricular surface, where they divide and differentiate into neurons, thereby leading to the cortical malformation.
|
30709655 |
2019 |
Aortic Aneurysm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We also examined the expression of mRNA encoding enzymes that catalyze making and removing epigenetic modifications by real-time PCR: we found that mRNA levels of DNA methyltransferase (DNMT) 1 and DNMT3A were higher in the AAA than in the HC group, mRNA levels of methyl-CpG-binding domain protein (MBD) 2 and MBD4 were higher in the AAA than in the HC group (MBD2: 6.21 ± 2.57 vs 3.04 ± 1.45; MBD4: 7.76 ± 3.48 vs 4.97 ± 3.10; both P < 0.05), and mRNA levels of histone deacetylase (HDAC) 1 and HDAC5 were significantly up-regulated in the AAA compared with the HC group (HDAC1: 2.17 ± 1.18 vs 1.51 ± 0.99; HDAC5: 1.35 ± 0.49 vs 0.94 ± 0.76; both P < 0.05).
|
31001930 |
2019 |
Malignant neoplasm of thyroid
|
0.010 |
Biomarker
|
disease |
BEFREE |
HDAC1 and HDAC2 Double Knockout Triggers Cell Apoptosis in Advanced Thyroid Cancer.
|
30669676 |
2019 |
Cognition Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Restoration of HDAC1 and HDAC2 activities (as evident from the increased acetylation of histones H3 and H4) using simvastatin significantly improves the cognitive deficit and social interaction behavior in AS mice.
|
31849603 |
2019 |
Angioimmunoblastic Lymphadenopathy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Results revealed that 55.8% of patients with PTCL-NOS, 57.1% of patients with NK/TCL, 86.7% of patients ALCL and 50% of patients with AITL highly expressed HDAC1.
|
31423206 |
2019 |
Kidney Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
These results strongly suggest that inhibition of HDAC1 and HDAC2 activities may suppress the progression of human proteinuric kidney diseases through the regulation of EGR1.
|
30776024 |
2019 |
Kidney Failure, Chronic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We identified 2 genes, histone deacetylase 1 (HDAC1) and HDAC2, contributing to the pathogenesis of proteinuric kidney diseases, the leading cause of end-stage kidney disease. mRNA expression profiling from proteinuric mouse glomeruli was linked to Connectivity Map databases, identifying HDAC1 and HDAC2 with the differentially expressed gene set reversible by HDAC inhibitors.
|
30776024 |
2019 |
Liver Cirrhosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
HDAC1 was expressed in reactive ducts and hepatocyte buds of liver tissues from patients with cirrhosis.
|
30267710 |
2019 |
Liver diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
P300 and HDAC1 can be involved in the development of various liver diseases by regulating gene transcription.
|
30786008 |
2019 |
Myocardial Infarction
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our results showed that ellagic acid significantly reduced protein expression of HDAC1, mRNA expression of collagen I, collagen III, MMP-2 and MMP-9 and the area of cardiac fibrosis in MI rats.
|
31168029 |
2019 |
Rhinitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Studies conducted related to allergic rhinitis have shown the elevation in the levels of HDAC1, 3 and 11 in the nasal epithelia and HDAC inhibitors have shown effectiveness in decreasing the symptoms of rhinitis.
|
30878818 |
2019 |
Kaposi Sarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings advance our understanding of the mechanism of KSHV-induced pathogenesis, and providing a rationale for therapeutic targeting of the vFLIP/SAP18/HDAC1 complex as a novel strategy of AIDS-KS.
|
30670829 |
2019 |
Thyroid Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
HDAC1 and HDAC2 Double Knockout Triggers Cell Apoptosis in Advanced Thyroid Cancer.
|
30669676 |
2019 |
Peripheral T-Cell Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The purpose of the present study was to investigate the clinical significance of enhancer of zeste homolog 2 (EZH2) and histone deacetylase 1 and 2 (HDAC1/2) expression in PTCL.
|
31423206 |
2019 |
Primary gout
|
0.010 |
Biomarker
|
disease |
BEFREE |
HDAC1/2 dual inhibition could therefore be a highly potent new treatment option for acute gout, although safety has to be determined in vivo.
|
30728075 |
2019 |
Aortic Aneurysm, Abdominal
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We also examined the expression of mRNA encoding enzymes that catalyze making and removing epigenetic modifications by real-time PCR: we found that mRNA levels of DNA methyltransferase (DNMT) 1 and DNMT3A were higher in the AAA than in the HC group, mRNA levels of methyl-CpG-binding domain protein (MBD) 2 and MBD4 were higher in the AAA than in the HC group (MBD2: 6.21 ± 2.57 vs 3.04 ± 1.45; MBD4: 7.76 ± 3.48 vs 4.97 ± 3.10; both P < 0.05), and mRNA levels of histone deacetylase (HDAC) 1 and HDAC5 were significantly up-regulated in the AAA compared with the HC group (HDAC1: 2.17 ± 1.18 vs 1.51 ± 0.99; HDAC5: 1.35 ± 0.49 vs 0.94 ± 0.76; both P < 0.05).
|
31001930 |
2019 |
Glomerulosclerosis (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
Podocyte HDAC1 and HDAC2 activities were increased in mice podocytopathy models, and podocyte-associated Hdac1 and Hdac2 genetic ablation improved proteinuria and glomerulosclerosis.
|
30776024 |
2019 |
Liposarcoma, Dedifferentiated
|
0.010 |
Biomarker
|
disease |
BEFREE |
<i>In vitro</i>, treatment of DDLPS cell lines with the HDAC inhibitors MI-192 (HDAC2/3 inhibitor) or romidepsin (HDAC1/2 inhibitor) reduced <i>MDM2</i> expression and induced apoptosis.
|
31620242 |
2019 |
Ki-1+ Anaplastic Large Cell Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Results revealed that 55.8% of patients with PTCL-NOS, 57.1% of patients with NK/TCL, 86.7% of patients ALCL and 50% of patients with AITL highly expressed HDAC1.
|
31423206 |
2019 |
Cholangiocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
ARID1A and histone deacetylase 1 were directly recruited to the ALDH1A1 promoter region in cholangiocarcinoma cells with undetectable ALDH1A expression by chromatin immunoprecipitation assay.
|
31665232 |
2019 |
Non-small cell lung cancer stage I
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Patients with high EZH2 and high HDAC1 expression in stage I NSCLC specimens of both datasets had the lowest survival compared to the patients with low expression of either or both markers.
|
31456359 |
2019 |
Deformity
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Developmental stage-specific depletion of both HDAC1 and HDAC2 in radial glial progenitors results in mispositioning of IPs at the ventricular surface, where they divide and differentiate into neurons, thereby leading to the cortical malformation.
|
30709655 |
2019 |
Amputated structure (morphologic abnormality)
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Supplementation of nerve factors BMP7, FGF2, and FGF8 in the stump ends after amputation on denervated limbs not only enabled HDAC1 up-regulation but also led to more extent of limb regeneration.
|
30826398 |
2019 |
Specific granule deficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
C/EBPε ΔRS derived from a neutrophil-specific granule deficiency patient interacts with HDAC1 and its dysfunction is restored by trichostatin A.
|
31256937 |
2019 |