HDAC1, histone deacetylase 1, 3065

N. diseases: 277; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3714506
Disease: Meckel syndrome type 1
Meckel syndrome type 1
0.010 Biomarker disease BEFREE Rescue of HDAC1 in NFAT2-knockdown GSCs partially restored tumor growth and MES phenotype. 31400279 2020
CUI: C0000768
Disease: Congenital Abnormality
Congenital Abnormality
0.010 AlteredExpression group BEFREE Developmental stage-specific depletion of both HDAC1 and HDAC2 in radial glial progenitors results in mispositioning of IPs at the ventricular surface, where they divide and differentiate into neurons, thereby leading to the cortical malformation. 30709655 2019
CUI: C0003486
Disease: Aortic Aneurysm
Aortic Aneurysm
0.010 AlteredExpression disease BEFREE We also examined the expression of mRNA encoding enzymes that catalyze making and removing epigenetic modifications by real-time PCR: we found that mRNA levels of DNA methyltransferase (DNMT) 1 and DNMT3A were higher in the AAA than in the HC group, mRNA levels of methyl-CpG-binding domain protein (MBD) 2 and MBD4 were higher in the AAA than in the HC group (MBD2: 6.21 ± 2.57 vs 3.04 ± 1.45; MBD4: 7.76 ± 3.48 vs 4.97 ± 3.10; both P < 0.05), and mRNA levels of histone deacetylase (HDAC) 1 and HDAC5 were significantly up-regulated in the AAA compared with the HC group (HDAC1: 2.17 ± 1.18 vs 1.51 ± 0.99; HDAC5: 1.35 ± 0.49 vs 0.94 ± 0.76; both P < 0.05). 31001930 2019
CUI: C0007115
Disease: Malignant neoplasm of thyroid
Malignant neoplasm of thyroid
0.010 Biomarker disease BEFREE HDAC1 and HDAC2 Double Knockout Triggers Cell Apoptosis in Advanced Thyroid Cancer. 30669676 2019
CUI: C0009241
Disease: Cognition Disorders
Cognition Disorders
0.010 Biomarker group BEFREE Restoration of HDAC1 and HDAC2 activities (as evident from the increased acetylation of histones H3 and H4) using simvastatin significantly improves the cognitive deficit and social interaction behavior in AS mice. 31849603 2019
CUI: C0020981
Disease: Angioimmunoblastic Lymphadenopathy
Angioimmunoblastic Lymphadenopathy
0.010 AlteredExpression disease BEFREE Results revealed that 55.8% of patients with PTCL-NOS, 57.1% of patients with NK/TCL, 86.7% of patients ALCL and 50% of patients with AITL highly expressed HDAC1. 31423206 2019
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.010 Biomarker group BEFREE These results strongly suggest that inhibition of HDAC1 and HDAC2 activities may suppress the progression of human proteinuric kidney diseases through the regulation of EGR1. 30776024 2019
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.010 AlteredExpression disease BEFREE We identified 2 genes, histone deacetylase 1 (HDAC1) and HDAC2, contributing to the pathogenesis of proteinuric kidney diseases, the leading cause of end-stage kidney disease. mRNA expression profiling from proteinuric mouse glomeruli was linked to Connectivity Map databases, identifying HDAC1 and HDAC2 with the differentially expressed gene set reversible by HDAC inhibitors. 30776024 2019
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.010 AlteredExpression disease BEFREE HDAC1 was expressed in reactive ducts and hepatocyte buds of liver tissues from patients with cirrhosis. 30267710 2019
CUI: C0023895
Disease: Liver diseases
Liver diseases
0.010 Biomarker group BEFREE P300 and HDAC1 can be involved in the development of various liver diseases by regulating gene transcription. 30786008 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.010 AlteredExpression disease BEFREE Our results showed that ellagic acid significantly reduced protein expression of HDAC1, mRNA expression of collagen I, collagen III, MMP-2 and MMP-9 and the area of cardiac fibrosis in MI rats. 31168029 2019
CUI: C0035455
Disease: Rhinitis
Rhinitis
0.010 AlteredExpression disease BEFREE Studies conducted related to allergic rhinitis have shown the elevation in the levels of HDAC1, 3 and 11 in the nasal epithelia and HDAC inhibitors have shown effectiveness in decreasing the symptoms of rhinitis. 30878818 2019
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.010 Biomarker disease BEFREE These findings advance our understanding of the mechanism of KSHV-induced pathogenesis, and providing a rationale for therapeutic targeting of the vFLIP/SAP18/HDAC1 complex as a novel strategy of AIDS-KS. 30670829 2019
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm
0.010 Biomarker disease BEFREE HDAC1 and HDAC2 Double Knockout Triggers Cell Apoptosis in Advanced Thyroid Cancer. 30669676 2019
CUI: C0079774
Disease: Peripheral T-Cell Lymphoma
Peripheral T-Cell Lymphoma
0.010 AlteredExpression disease BEFREE The purpose of the present study was to investigate the clinical significance of enhancer of zeste homolog 2 (EZH2) and histone deacetylase 1 and 2 (HDAC1/2) expression in PTCL. 31423206 2019
CUI: C0149896
Disease: Primary gout
Primary gout
0.010 Biomarker disease BEFREE HDAC1/2 dual inhibition could therefore be a highly potent new treatment option for acute gout, although safety has to be determined in vivo. 30728075 2019
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal
0.010 AlteredExpression disease BEFREE We also examined the expression of mRNA encoding enzymes that catalyze making and removing epigenetic modifications by real-time PCR: we found that mRNA levels of DNA methyltransferase (DNMT) 1 and DNMT3A were higher in the AAA than in the HC group, mRNA levels of methyl-CpG-binding domain protein (MBD) 2 and MBD4 were higher in the AAA than in the HC group (MBD2: 6.21 ± 2.57 vs 3.04 ± 1.45; MBD4: 7.76 ± 3.48 vs 4.97 ± 3.10; both P < 0.05), and mRNA levels of histone deacetylase (HDAC) 1 and HDAC5 were significantly up-regulated in the AAA compared with the HC group (HDAC1: 2.17 ± 1.18 vs 1.51 ± 0.99; HDAC5: 1.35 ± 0.49 vs 0.94 ± 0.76; both P < 0.05). 31001930 2019
CUI: C0178664
Disease: Glomerulosclerosis (disorder)
Glomerulosclerosis (disorder)
0.010 Biomarker disease BEFREE Podocyte HDAC1 and HDAC2 activities were increased in mice podocytopathy models, and podocyte-associated Hdac1 and Hdac2 genetic ablation improved proteinuria and glomerulosclerosis. 30776024 2019
CUI: C0205824
Disease: Liposarcoma, Dedifferentiated
Liposarcoma, Dedifferentiated
0.010 Biomarker disease BEFREE <i>In vitro</i>, treatment of DDLPS cell lines with the HDAC inhibitors MI-192 (HDAC2/3 inhibitor) or romidepsin (HDAC1/2 inhibitor) reduced <i>MDM2</i> expression and induced apoptosis. 31620242 2019
Ki-1+ Anaplastic Large Cell Lymphoma
0.010 AlteredExpression disease BEFREE Results revealed that 55.8% of patients with PTCL-NOS, 57.1% of patients with NK/TCL, 86.7% of patients ALCL and 50% of patients with AITL highly expressed HDAC1. 31423206 2019
CUI: C0206698
Disease: Cholangiocarcinoma
Cholangiocarcinoma
0.010 AlteredExpression disease BEFREE ARID1A and histone deacetylase 1 were directly recruited to the ALDH1A1 promoter region in cholangiocarcinoma cells with undetectable ALDH1A expression by chromatin immunoprecipitation assay. 31665232 2019
CUI: C0278504
Disease: Non-small cell lung cancer stage I
Non-small cell lung cancer stage I
0.010 AlteredExpression disease BEFREE Patients with high EZH2 and high HDAC1 expression in stage I NSCLC specimens of both datasets had the lowest survival compared to the patients with low expression of either or both markers. 31456359 2019
CUI: C0302142
Disease: Deformity
Deformity
0.010 AlteredExpression group BEFREE Developmental stage-specific depletion of both HDAC1 and HDAC2 in radial glial progenitors results in mispositioning of IPs at the ventricular surface, where they divide and differentiate into neurons, thereby leading to the cortical malformation. 30709655 2019
Amputated structure (morphologic abnormality)
0.010 AlteredExpression phenotype BEFREE Supplementation of nerve factors BMP7, FGF2, and FGF8 in the stump ends after amputation on denervated limbs not only enabled HDAC1 up-regulation but also led to more extent of limb regeneration. 30826398 2019
CUI: C0398593
Disease: Specific granule deficiency
Specific granule deficiency
0.010 Biomarker disease BEFREE C/EBPε ΔRS derived from a neutrophil-specific granule deficiency patient interacts with HDAC1 and its dysfunction is restored by trichostatin A. 31256937 2019