HDAC1, histone deacetylase 1, 3065

N. diseases: 277; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.100 AlteredExpression disease BEFREE Histone deacetylase 1 represses the small GTPase RhoB expression in human nonsmall lung carcinoma cell line. 13679859 2003
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
0.050 Biomarker disease BEFREE Furthermore, we determined that HDAC1 complexed with Sp1 in PDAC cells and that TSA treatment interfered with this association. 12750289 2003
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression group BEFREE Our data also revealed accumulation of ICBP90 in breast-cancer cells, where it might suppress expression of tumor suppressor genes through deacetylation of histones after recruitment of HDAC1. 15361834 2004
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.100 AlteredExpression disease BEFREE HDAC1/GAPDH mRNA levels were significantly higher in T3 or T4 lung carcinoma (54.326 +/- 127.018) than in T1 or T2 lung cancers (14.790 +/- 48.670, P = 0.1601). 15474665 2004
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.100 AlteredExpression disease BEFREE The HDAC1/GAPDH mRNA levels were significantly higher in stage III or IV lung cancer (50.929 +/- 120.433) than in stage I lung cancer (11.430 +/- 25.611, P = 0.0472). 15474665 2004
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.090 AlteredExpression disease BEFREE The HDAC1/GAPDH mRNA levels were significantly higher in stage III or IV lung cancer (50.929 +/- 120.433) than in stage I lung cancer (11.430 +/- 25.611, P = 0.0472). 15474665 2004
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.030 Biomarker group LHGDN Restoration of transforming growth factor-beta signaling through receptor RI induction by histone deacetylase activity inhibition in breast cancer cells. 15155736 2004
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.020 AlteredExpression group LHGDN Upregulation and nuclear recruitment of HDAC1 in hormone refractory prostate cancer. 15042618 2004
CUI: C2981344
Disease: Stage I Lung Cancer AJCC v6
Stage I Lung Cancer AJCC v6
0.010 AlteredExpression disease BEFREE The HDAC1/GAPDH mRNA levels were significantly higher in stage III or IV lung cancer (50.929 +/- 120.433) than in stage I lung cancer (11.430 +/- 25.611, P = 0.0472). 15474665 2004
CUI: C4521966
Disease: Stage I Lung Cancer AJCC v7
Stage I Lung Cancer AJCC v7
0.010 AlteredExpression disease BEFREE The HDAC1/GAPDH mRNA levels were significantly higher in stage III or IV lung cancer (50.929 +/- 120.433) than in stage I lung cancer (11.430 +/- 25.611, P = 0.0472). 15474665 2004
CUI: C4526713
Disease: Stage I Lung Cancer AJCC v8
Stage I Lung Cancer AJCC v8
0.010 AlteredExpression disease BEFREE The HDAC1/GAPDH mRNA levels were significantly higher in stage III or IV lung cancer (50.929 +/- 120.433) than in stage I lung cancer (11.430 +/- 25.611, P = 0.0472). 15474665 2004
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.100 AlteredExpression disease BEFREE These results imply that HDAC1 mRNA expression could have potential as an endocrine response marker and may have prognostic implications for breast cancer progression. 16172792 2005
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression group BEFREE It was found that HDAC1 mRNA was expressed at significantly higher levels in tumors from patients over 50 years of age and in those tumors without axillary lymph node involvement, that are less than 2 cm, that are of a non-high histological grade, that are HER2 negative and that are ERalpha/PgR positive. 16172792 2005
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.100 Biomarker disease BEFREE Altogether, our findings indicate that epithelial and stromal cells exhibit distinct class I HDAC expression profiles, and the abundance of HDAC1 is not altered in human prostate cancer. 15590418 2005
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 Biomarker disease BEFREE Altogether, our findings indicate that epithelial and stromal cells exhibit distinct class I HDAC expression profiles, and the abundance of HDAC1 is not altered in human prostate cancer. 15590418 2005
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 AlteredExpression disease BEFREE These results imply that HDAC1 mRNA expression could have potential as an endocrine response marker and may have prognostic implications for breast cancer progression. 16172792 2005
CUI: C0035335
Disease: Retinoblastoma
Retinoblastoma
0.050 AlteredExpression disease BEFREE Following the subcloning of the promoter regions into a gene reporter system, we found that at least four promoter haplotypes associated with CCND1, E2F1, HDAC1 and RB1 significantly influenced transcriptional activity in an allele-specific manner. 16081466 2005
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.030 AlteredExpression group LHGDN Quantitation of HDAC1 mRNA expression in invasive carcinoma of the breast*. 16172792 2005
CUI: C0853879
Disease: Invasive carcinoma of breast
Invasive carcinoma of breast
0.020 AlteredExpression disease BEFREE In the present study, the level of expression of HDAC1 mRNA was assessed by LightCycler-based quantitative real-time reverse transcriptase (RT)-PCR analysis in 162 cases of invasive carcinoma of the breast. 16172792 2005
CUI: C0015695
Disease: Fatty Liver
Fatty Liver
0.010 Biomarker disease BEFREE The HDAC1 transgenic mice exhibited a high incidence of hepatic steatosis and nuclear pleomorphism. 15796905 2005
CUI: C0032584
Disease: polyps
polyps
0.010 Biomarker phenotype BEFREE We show that the upregulation of HDAC2 in colorectal cancer occurred early at the polyp stage, was more robust and occurred more frequently than HDAC1. 15665816 2005
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis
0.010 Biomarker disease BEFREE The HDAC1 transgenic mice exhibited a high incidence of hepatic steatosis and nuclear pleomorphism. 15796905 2005
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation
0.200 Biomarker phenotype RGD Uteroplacental insufficiency affects epigenetic determinants of chromatin structure in brains of neonatal and juvenile IUGR rats. 16380407 2006
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 Biomarker phenotype BEFREE Collectively, our data provide evidence of a positive cross-talk between HIF-1alpha and MTA1, which is mediated by HDAC1 recruitment, and indicate a close connection between MTA1-associated metastasis and HIF-1-induced tumor angiogenesis. 16511565 2006
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE Consistent with its tumor suppressor functions, NKX3.1 engages cell cycle and cell death machinery via association with HDAC1, leading to increased p53 acetylation and half-life through MDM2-dependent mechanisms. 16697957 2006