Carcinoma of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Histone deacetylase 1 represses the small GTPase RhoB expression in human nonsmall lung carcinoma cell line.
|
13679859 |
2003 |
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.050 |
Biomarker
|
disease |
BEFREE |
Furthermore, we determined that HDAC1 complexed with Sp1 in PDAC cells and that TSA treatment interfered with this association.
|
12750289 |
2003 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our data also revealed accumulation of ICBP90 in breast-cancer cells, where it might suppress expression of tumor suppressor genes through deacetylation of histones after recruitment of HDAC1.
|
15361834 |
2004 |
Malignant neoplasm of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
HDAC1/GAPDH mRNA levels were significantly higher in T3 or T4 lung carcinoma (54.326 +/- 127.018) than in T1 or T2 lung cancers (14.790 +/- 48.670, P = 0.1601).
|
15474665 |
2004 |
Carcinoma of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The HDAC1/GAPDH mRNA levels were significantly higher in stage III or IV lung cancer (50.929 +/- 120.433) than in stage I lung cancer (11.430 +/- 25.611, P = 0.0472).
|
15474665 |
2004 |
Primary malignant neoplasm of lung
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
The HDAC1/GAPDH mRNA levels were significantly higher in stage III or IV lung cancer (50.929 +/- 120.433) than in stage I lung cancer (11.430 +/- 25.611, P = 0.0472).
|
15474665 |
2004 |
Mammary Neoplasms
|
0.030 |
Biomarker
|
group |
LHGDN |
Restoration of transforming growth factor-beta signaling through receptor RI induction by histone deacetylase activity inhibition in breast cancer cells.
|
15155736 |
2004 |
Prostatic Neoplasms
|
0.020 |
AlteredExpression
|
group |
LHGDN |
Upregulation and nuclear recruitment of HDAC1 in hormone refractory prostate cancer.
|
15042618 |
2004 |
Stage I Lung Cancer AJCC v6
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The HDAC1/GAPDH mRNA levels were significantly higher in stage III or IV lung cancer (50.929 +/- 120.433) than in stage I lung cancer (11.430 +/- 25.611, P = 0.0472).
|
15474665 |
2004 |
Stage I Lung Cancer AJCC v7
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The HDAC1/GAPDH mRNA levels were significantly higher in stage III or IV lung cancer (50.929 +/- 120.433) than in stage I lung cancer (11.430 +/- 25.611, P = 0.0472).
|
15474665 |
2004 |
Stage I Lung Cancer AJCC v8
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The HDAC1/GAPDH mRNA levels were significantly higher in stage III or IV lung cancer (50.929 +/- 120.433) than in stage I lung cancer (11.430 +/- 25.611, P = 0.0472).
|
15474665 |
2004 |
Malignant neoplasm of breast
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results imply that HDAC1 mRNA expression could have potential as an endocrine response marker and may have prognostic implications for breast cancer progression.
|
16172792 |
2005 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
It was found that HDAC1 mRNA was expressed at significantly higher levels in tumors from patients over 50 years of age and in those tumors without axillary lymph node involvement, that are less than 2 cm, that are of a non-high histological grade, that are HER2 negative and that are ERalpha/PgR positive.
|
16172792 |
2005 |
Malignant neoplasm of prostate
|
0.100 |
Biomarker
|
disease |
BEFREE |
Altogether, our findings indicate that epithelial and stromal cells exhibit distinct class I HDAC expression profiles, and the abundance of HDAC1 is not altered in human prostate cancer.
|
15590418 |
2005 |
Prostate carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Altogether, our findings indicate that epithelial and stromal cells exhibit distinct class I HDAC expression profiles, and the abundance of HDAC1 is not altered in human prostate cancer.
|
15590418 |
2005 |
Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results imply that HDAC1 mRNA expression could have potential as an endocrine response marker and may have prognostic implications for breast cancer progression.
|
16172792 |
2005 |
Retinoblastoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Following the subcloning of the promoter regions into a gene reporter system, we found that at least four promoter haplotypes associated with CCND1, E2F1, HDAC1 and RB1 significantly influenced transcriptional activity in an allele-specific manner.
|
16081466 |
2005 |
Mammary Neoplasms
|
0.030 |
AlteredExpression
|
group |
LHGDN |
Quantitation of HDAC1 mRNA expression in invasive carcinoma of the breast*.
|
16172792 |
2005 |
Invasive carcinoma of breast
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In the present study, the level of expression of HDAC1 mRNA was assessed by LightCycler-based quantitative real-time reverse transcriptase (RT)-PCR analysis in 162 cases of invasive carcinoma of the breast.
|
16172792 |
2005 |
Fatty Liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
The HDAC1 transgenic mice exhibited a high incidence of hepatic steatosis and nuclear pleomorphism.
|
15796905 |
2005 |
polyps
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We show that the upregulation of HDAC2 in colorectal cancer occurred early at the polyp stage, was more robust and occurred more frequently than HDAC1.
|
15665816 |
2005 |
Steatohepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The HDAC1 transgenic mice exhibited a high incidence of hepatic steatosis and nuclear pleomorphism.
|
15796905 |
2005 |
Fetal Growth Retardation
|
0.200 |
Biomarker
|
phenotype |
RGD |
Uteroplacental insufficiency affects epigenetic determinants of chromatin structure in brains of neonatal and juvenile IUGR rats.
|
16380407 |
2006 |
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Collectively, our data provide evidence of a positive cross-talk between HIF-1alpha and MTA1, which is mediated by HDAC1 recruitment, and indicate a close connection between MTA1-associated metastasis and HIF-1-induced tumor angiogenesis.
|
16511565 |
2006 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Consistent with its tumor suppressor functions, NKX3.1 engages cell cycle and cell death machinery via association with HDAC1, leading to increased p53 acetylation and half-life through MDM2-dependent mechanisms.
|
16697957 |
2006 |