HDAC1, histone deacetylase 1, 3065

N. diseases: 277; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0264408
Disease: Childhood asthma
Childhood asthma 		0.010 Biomarker disease BEFREE These results suggested that FBXO6, HDAC1 and APP may interact with PCNA, ITGA4, CTNNA1, NF‑κB1 and mTOR in the progression of asthma in children. 29956778 2018
CUI: C0521607
Disease: Peritoneal Fibrosis
Peritoneal Fibrosis 		0.010 Biomarker disease BEFREE Overall, our study, pinpointing a role for HDAC1, revealed a new player in the regulation of peritoneal fibrosis, providing the rationale for future therapeutic opportunities. 29855565 2018
CUI: C0917805
Disease: Transient Cerebral Ischemia
Transient Cerebral Ischemia 		0.010 Biomarker disease BEFREE TOPK Promotes Microglia/Macrophage Polarization towards M2 Phenotype via Inhibition of HDAC1 and HDAC2 Activity after Transient Cerebral Ischemia. 29896413 2018
CUI: C1270972
Disease: Mild cognitive disorder
Mild cognitive disorder 		0.010 Biomarker disease BEFREE Immunoblots revealed significant increases in HDAC1 and HDAC3 in MCI and mAD, followed by a decrease in sAD compared to NCI. 29439356 2018
CUI: C1275278
Disease: Extraskeletal Myxoid Chondrosarcoma
Extraskeletal Myxoid Chondrosarcoma 		0.010 AlteredExpression disease BEFREE HDAC1 nuclear expression adversely affected overall survival in SEC (P=0.02) and EMC (P=0.03), and HDAC7 cytoplasmic expression in CCC was associated with a poor prognosis (P=0.06). 29456726 2018
CUI: C1290884
Disease: Inflammatory disorder
Inflammatory disorder 		0.010 Biomarker group BEFREE Targeting the butyrate-HDAC1-T-cell axis offers an effective novel approach in the treatment of inflammatory disease. 29796620 2018
CUI: C1328504
Disease: Hormone refractory prostate cancer
Hormone refractory prostate cancer 		0.010 Biomarker disease BEFREE However, the results of clinical studies using HDAC inhibitors (directed against HDAC1, 2, 3, and 8) in CRPC are equivocal, a result that some have attributed to their ability to induce an epithelial to mesenchymal transition (EMT) and neuroendocrine differentiation. 29243324 2018
CUI: C1333064
Disease: Classical Hodgkin's Lymphoma
Classical Hodgkin's Lymphoma 		0.010 AlteredExpression disease BEFREE Increased expression of HDAC1 was correlated negatively with progression-free survival and OS, and increased expression of HDAC11 had a borderline relationship with the OS rate in patients with cHL. 29481474 2018
CUI: C1961102
Disease: Precursor Cell Lymphoblastic Leukemia Lymphoma
Precursor Cell Lymphoblastic Leukemia Lymphoma 		0.010 Biomarker disease BEFREE HDAC1,2 inhibition and doxorubicin impair Mre11-dependent DNA repair and DISC to override BCR-ABL1-driven DSB repair in Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia. 28579617 2018
CUI: C1969372
Disease: Tubulointerstitial fibrosis
Tubulointerstitial fibrosis 		0.010 Biomarker phenotype BEFREE Inhibition of histone deacetylase 1 ameliorates renal tubulointerstitial fibrosis via modulation of inflammation and extracellular matrix gene transcription in mice. 29115561 2018
CUI: C2347747
Disease: Adult Classical Hodgkin Lymphoma
Adult Classical Hodgkin Lymphoma 		0.010 AlteredExpression disease BEFREE Increased expression of HDAC1 was correlated negatively with progression-free survival and OS, and increased expression of HDAC11 had a borderline relationship with the OS rate in patients with cHL. 29481474 2018
CUI: C0017601
Disease: Glaucoma
Glaucoma 		0.010 Biomarker disease BEFREE Therefore, the current study concluded that 6 DEGs, including HEPH, SELENBP1, RFTN1, ID1, HDAC‑1 and PBX1 and three TFs, including FOXD3, HNF‑4 and AP‑1 may be involved with the pathogenesis of glaucoma. 28990066 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.010 Biomarker group BEFREE VPA prevented HFD-induced hypertension by downregulating angiotensin II and its receptor via inhibition of HDAC1, offering a novel therapeutic option for HFD-induced hypertension. 28720877 2017
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma 		0.010 AlteredExpression disease BEFREE Translation of cugWT1 is initiated from a CUG codon upstream and in-frame with the coding region of augWT1. cugWT1 induced cell transformation and increased the gene expression of c-myc, bcl-2 and egfr, whereas overexpression of augWT1 repressed colony formation of cancer cells and inhibited the expression of the same target genes by recruiting histone deacetylase 1 (HDAC1). 29040381 2017
CUI: C0038443
Disease: Stress, Psychological
Stress, Psychological 		0.010 Biomarker disease BEFREE HDAC1 links early life stress to schizophrenia-like phenotypes. 28533418 2017
CUI: C0038826
Disease: Superinfection
Superinfection 		0.010 Biomarker group BEFREE HIV superinfection initially downregulated HDAC1 and upregulated acetyl-histone H3 and histone H3 (K4), while HIV-2 superinfection demonstrated an increase in HDAC1 and a decrease in acetyl-histone H3 and histone H3 (K4) relative to HIV-1 superinfection. 27662631 2017
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.010 Biomarker disease BEFREE HDAC1 gene/protein expressions were increased in TB patients as compared with that in HS, whereas KDM6B gene/protein expressions were decreased. 28469799 2017
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary 		0.010 AlteredExpression disease BEFREE Histone H3K14 hypoacetylation and H3K27 hypermethylation along with HDAC1 up-regulation and KDM6B down-regulation are associated with active pulmonary tuberculosis disease. 28469799 2017
CUI: C0154251
Disease: Lipid Metabolism Disorders
Lipid Metabolism Disorders 		0.010 Biomarker group BEFREE These data suggest that HDAC1-related H3K9ac plays a key role in Hcy-mediated lipid metabolism disorders, and that miR-34a may be a novel therapeutic target in Hcy-related atherosclerosis.. 28485501 2017
CUI: C0238339
Disease: Hereditary pancreatitis
Hereditary pancreatitis 		0.010 AlteredExpression disease BEFREE HP infection could promote HDAC1 and HDAC4 expression as determined by Western blotting. 28700998 2017
CUI: C0267026
Disease: Actinic cheilitis
Actinic cheilitis 		0.010 Biomarker disease BEFREE HDAC1 and HAT1 nuclear immunostaining were higher in AC, with no statistical significance. 28107582 2017
CUI: C0279530
Disease: Malignant Bone Neoplasm
Malignant Bone Neoplasm 		0.010 AlteredExpression disease BEFREE Bone cancer caused significantly increased expression of HDAC1 in spinal microglia and neurons, with HDAC2 markedly increased in spinal astrocytes, which were accompanied by the upregulation of MAPK pathways and the activation of microglia and astrocytes in the SDH. 29096654 2017
CUI: C0333983
Disease: Hyperplastic Polyp
Hyperplastic Polyp 		0.010 AlteredExpression disease BEFREE HP infection could promote HDAC1 and HDAC4 expression as determined by Western blotting. 28700998 2017
CUI: C0595921
Disease: Intraocular pressure disorder
Intraocular pressure disorder 		0.010 AlteredExpression disease BEFREE Based on the RT‑qPCR results, the expression levels of 3 DEGs, raftlin, lipid raft linker 1 (RFTN1), PBX homeobox 1 (PBX1), HDAC1 were significantly upregulated and the expression of GEM was significantly downregulated in acute IOP elevation rat model at the first and fifth day. 28990066 2017
CUI: C0685938
Disease: Malignant neoplasm of gastrointestinal tract
Malignant neoplasm of gastrointestinal tract 		0.010 AlteredExpression disease BEFREE We found that the expression level of HDAC1 in gastrointestinal malignancies, especially in colorectal cancer (OR = 10.84, 95% CI = 5.33-22.07, P< 0.00001), was higher than that in noncancerous tissue, and HDAC1 expression was closely associated with some clinical features of gastrointestinal cancer patients, such as tumor stage (OR = 1.62, 95% CI = 1.28-2.05, P < 0.0001) and tumor grade (OR = 1.75, 95% CI = 1.03-2.95, P = 0.04). 28424407 2017