|
Alzheimer's Disease
|
0.700 |
Biomarker
|
disease |
HPO |
|
|
|
|
Alzheimer's Disease
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
Alzheimer's Disease
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
Alzheimer's Disease
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Alzheimer's Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
The hemochromatosis gene affects the age of onset of sporadic Alzheimer's disease.
|
11445256 |
2001 |
|
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Moreover, several studies have suggested that HFE mutations may be involved in several age-related chronic diseases such as Alzheimer's disease (AD) and coronary heart disease, but apparently paradoxically also with longevity.
|
12714262 |
2003 |
|
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Interaction of the H63D mutation in the hemochromatosis gene with the apolipoprotein E epsilon 4 allele modulates age at onset of Alzheimer's disease.
|
12584430 |
2003 |
|
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Although confirmation is required, these findings suggest that HFE mutations are associated with increased oxidative stress and Braak stage, and that HFE and APOE genotypes are different between AD patients, high pathology and low pathology controls.
|
12707938 |
2003 |
|
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Although confirmation is required, these findings suggest that HFE mutations are associated with increased oxidative stress and Braak stage, and that HFE and APOE genotypes are different between AD patients, high pathology and low pathology controls.
|
12707938 |
2003 |
|
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Evaluation of HFE (hemochromatosis) mutations as genetic modifiers in sporadic AD and MCI.
|
15013567 |
2004 |
|
Alzheimer's Disease
|
0.700 |
Biomarker
|
disease |
CTD_human |
We have examined the interaction between the C2 variant of the transferrin (TF) gene and the C282Y allele of the haemochromatosis (HFE) gene as risk factors for developing AD.
|
15060098 |
2004 |
|
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
We have examined the interaction between the C2 variant of the transferrin (TF) gene and the C282Y allele of the haemochromatosis (HFE) gene as risk factors for developing AD.
|
15060098 |
2004 |
|
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We have examined the interaction between the C2 variant of the transferrin (TF) gene and the C282Y allele of the haemochromatosis (HFE) gene as risk factors for developing AD.
|
15060098 |
2004 |
|
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The genetic discovery that alleles in the hemochromatosis gene accelerate the onset of disease by five years has certainly validated interest in the metallobiology of AD as originally described by biochemical criteria.
|
15270200 |
2004 |
|
Alzheimer's Disease
|
0.700 |
Biomarker
|
disease |
CTD_human |
Iron genes, iron load and risk of Alzheimer's disease.
|
17047092 |
2006 |
|
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Recently a number of studies have begun to investigate the frequency of mutations in the HFE gene in AD.
|
17119292 |
2006 |
|
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
APOE epsilon 4 allele was associated with an increased risk of AD and an earlier age at onset, whereas no association was found between TFC2 or HFE C282Y mutation and disease susceptibility.
|
17011669 |
2007 |
|
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this pilot study, common variants of the apolipoprotein E (APOE) and HFE genes resulting in the iron overload disorder of hereditary hemochromatosis (C282Y, H63D and S65C) were evaluated as factors in sporadic AD in an Ontario sample in which folic acid fortification has been mandatory since 1998.
|
18525129 |
2008 |
|
Alzheimer's Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
HFE participates in the regulation of iron metabolism, its mutations are primary cause of hereditary hemochromatosis and appear to be more frequent in neurodegenerative disorders such as Alzheimer's disease and amyotrophic lateral sclerosis.
|
18325820 |
2008 |
|
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that HFE variants are not strong determinants of AD in the general population but may modify the age of onset.
|
17628213 |
2009 |
|
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Recent studies that alleles in the hemochromatosis gene may accelerate the onset of Alzheimer's disease by five years have validated interest in the model in which metals (particularly iron) accelerate disease course.
|
19166904 |
2009 |
|
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
CAT53 and HFE alleles in Alzheimer's disease: a putative protective role of the C282Y HFE mutation.
|
19429178 |
2009 |
|
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
(2004); J Med Genet 41:261-265] reported that epistatic interaction between rs1049296 (rs1049296" genes_norm="7018">P589S) in the transferrin gene (TF) and rs1800562 (C282Y) in the hemochromatosis gene (HFE) results in significant association with risk for AD.
|
20029940 |
2010 |
|
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Previous studies in cell models have shown the H63D HFE variant to result in increased cellular iron, oxidative stress, glutamate dyshomeostasis, and an increase in tau phosphorylation; all processes thought to contribute to AD pathology.
|
20060900 |
2010 |
|
Alzheimer's Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These findings support our hypothesis that the presence of the HFE H63D allele enables factors that trigger neurodegenerative processes associated with AD and predisposes cells to cytotoxcity.
|
20734416 |
2010 |