Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We determined prevalence of chronic HCV infection in consecutive Alabama and Ontario referred adults with HFE p.C282Y homozygosity.
|
31056361 |
2020 |
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we correlated different host single-nucleotide polymorphisms (SNPs) in the IL28B, CTLA4, LDLr, and HFE genes and mitochondrial DNA (mtDNA) haplogroups with the outcome of HCV infection and the response to pegylated-interferon plus ribavirin (pegIFN-RBV) treatment.
|
25296442 |
2014 |
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To investigate the association of progression of HCC with ghrelin and HFE gene polymorphisms in HCV Egyptian patients.
|
23845776 |
2013 |
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Hepatitis B virus (4% and 9%; P = 0.04) and hepatitis C virus (6% and 19%; P = 0.002) infections were more frequent in patients with non-HFE-related iron overload.
|
20101754 |
2010 |
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In contrast, livers with hepatitis C showed a similar frequency of HFE mutations as the general population: C282Y=15%, H63D=27%.
|
20208481 |
2010 |
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Porphyria cutanea tarda, hepatitis C, uroporphyrinogen decarboxylase and mutations of HFE gene. A case-control study.
|
19001803 |
2009 |
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Hemochromatosis gene (HFE) mutations and the hepatitis C virus (HCV) are known risk factors for porphyria cutanea tarda (PCT), but interactions with erythrocytic uroporphyrinogen decarboxylase (UROD) have seldom been addressed.
|
19001803 |
2009 |
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To determine the prevalence of the HFE gene mutations p.Cys282Tyr (C282Y), p.His63Asp (H63D) and p.Ser65Cys (S65C), the p.Tyr250X (Y250X) mutation of the TFR2 gene, and HCV infection in patients with PCT in the Czech population, and to make comparison of the iron status among the respective genotypes.
|
18565178 |
2008 |
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The prevalence of HFE C282Y gene mutation is increased in Spanish patients with porphyria cutanea tarda without hepatitis C virus infection.
|
17062032 |
2006 |
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of this work was to assess the influence of HFE mutations and serum and hepatic measures of iron status on baseline features and response to lead-in therapy in subjects with advanced chronic hepatitis C enrolled in the Hepatitis C Anti-viral Long-term Treatment to prevent Cirrhosis (HALT-C) Trial.
|
17101320 |
2006 |
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The relationship of H63D HFE gene mutations with chronic hepatitis C and the possible influence of HCV infection on iron metabolism needs further analysis.
|
16273299 |
2005 |
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In all subjects, hepatitis B surface antigen (HBsAg), anti-HCV and HFE gene mutations were assayed; alcohol intake was recorded by history.
|
15894495 |
2005 |
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Additional tests for hepatitis C virus (HCV) and hemochromatosis gene mutations were carried out.
|
15761419 |
2005 |
Hepatitis C
|
0.400 |
Biomarker
|
disease |
CTD_human |
Ribavirin in the treatment of hepatitis C.
|
15865084 |
2005 |
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Iron, the HFE gene, and hepatitis C.
|
15464655 |
2004 |
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Therefore our aim was to assess associations between HFE mutations and hepatic inflammation and stage of fibrosis in German hepatitis C patients.
|
15287851 |
2004 |
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The recent increasing contribution of hepatitis C virus infection to PCT in Japan has also been recognized. but there have been no PCT cases in Japan with HFE gene mutations.
|
15239394 |
2004 |
Hepatitis C
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, the presence of HCV infection was determined and related to the patients' HFE gene status.
|
15101996 |
2004 |
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Severe alterations of the HFE gene (42 patients, 28%), hepatitis C virus infection (33 patients, 22%), and dysmetabolic syndrome with iron overload (DSIO) (22 patients, 15%) emerged as the main causes, and other single causes were found in 20 patients (13%).
|
12601495 |
2003 |
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To investigate the relations between hemochromatosis gene (HFE) mutations and PCT in the south of France and their links with chronic hepatitis C virus (HCV) infection.
|
12673077 |
2003 |
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
our results suggest that the C282Y mutation, but not the H63D mutation, of the HFE gene is frequently associated with stainable iron in the liver in HCV-related chronic hepatitis.
|
14972004 |
2003 |
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that HFE mutations accelerate hepatic fibrosis in hepatitis C but may not be responsible for progression to end-stage liver disease.
|
12557137 |
2003 |
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In HCV-infected patients, heterozygosity for the C282Y mutation in HFE was significantly associated with elevated serum ferritin levels, stainable liver iron, and advanced fibrosis or cirrhosis (F2-F4).
|
14557859 |
2003 |
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Screening for HFE mutations should be considered in HCV infection.
|
12586300 |
2003 |
Hepatitis C
|
0.400 |
Biomarker
|
disease |
BEFREE |
Serum markers of iron status and HFE mutations were determined in 179 patients with alcoholic cirrhosis and 98 patients with hepatitis B and/or hepatitis C virus-related cirrhosis.
|
12003382 |
2002 |