Malignant neoplasm of breast
|
0.300 |
Biomarker
|
disease |
MGD |
|
|
|
Malignant neoplasm of breast
|
0.300 |
Biomarker
|
disease |
BEFREE |
Hepatocyte growth factor/scatter factor (HGF/SF), via its receptor c-MET, has been implicated to play a pivotal role in breast cancer development and progression.
|
11489839 |
2001 |
Malignant neoplasm of breast
|
0.300 |
Biomarker
|
disease |
BEFREE |
HGF and Met are therefore candidate targets for therapeutic intervention in the treatment of breast cancer.
|
11934261 |
2002 |
Malignant neoplasm of breast
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Hepatocyte growth factor enhances CXCR4 expression favoring breast cancer cell invasiveness.
|
16112111 |
2005 |
Malignant neoplasm of breast
|
0.300 |
Biomarker
|
disease |
BEFREE |
HGF is considered to be a marker of progression and of the aggressiveness of breast cancer; our data fully corresponds to this.
|
22199345 |
2011 |
Malignant neoplasm of breast
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
HGF was highly expressed in breast cancer patients and was not associated with patient age, location, size or hormone receptor status of the tumor (P>0.05), however, HGF expression was associated with tumor‑node‑metastasis (TNM) clinical stage, histological grade, lymph node metastasis and prognosis (P<0.05).
|
25351134 |
2015 |
Malignant neoplasm of breast
|
0.300 |
Biomarker
|
disease |
BEFREE |
Hepatocyte growth factor induces breast cancer cell invasion via the PI3K/Akt and p38 MAPK signaling pathways to up-regulate the expression of COX2.
|
28861172 |
2017 |
Malignant neoplasm of breast
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
HGF/SF and c-met were determined in 73 breast cancers (median follow up: 61 months) and 10 samples of tumour-free breast tissue.
|
8837300 |
1996 |
Malignant neoplasm of breast
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Certain well-known oncogenes (MYC and HGF), cytokines (CSF2, IFNG and IL5) and microRNAs (miR-21, miR-155-5p and let-7) may participate in the ILF2 expression network in breast cancer.
|
30018709 |
2018 |
Malignant neoplasm of breast
|
0.300 |
Biomarker
|
disease |
BEFREE |
Cooperative Effect of Oncogenic <i>MET</i> and <i>PIK3CA</i> in an HGF-Dominant Environment in Breast Cancer.
|
30518672 |
2019 |
Malignant neoplasm of breast
|
0.300 |
Biomarker
|
disease |
BEFREE |
Deregulation of hepatocyte growth factor (HGF)/mesenchymal-epithelial transition factor (MET) signalling has been associated with poor clinical outcome in breast cancer and other cancers.
|
24910416 |
2014 |
Malignant neoplasm of breast
|
0.300 |
Biomarker
|
disease |
BEFREE |
Detection of hepatocyte growth factor/scatter factor receptor (c-Met) in axillary drainage after operations for breast cancer using reverse transcriptase-polymerase chain reaction.
|
12793903 |
2003 |
Malignant neoplasm of breast
|
0.300 |
Biomarker
|
disease |
BEFREE |
Extracellular superoxide dismutase inhibits hepatocyte growth factor-mediated breast cancer-fibroblast interactions.
|
29296173 |
2017 |
Malignant neoplasm of breast
|
0.300 |
Biomarker
|
disease |
BEFREE |
Finally, decreased cell viability of Met receptor expressing breast cancer cells treated with delphinidin argues for a potential role of the agent in the prevention of HGF-mediated activation of various signaling pathways implicated in breast cancer.
|
18499206 |
2008 |
Malignant neoplasm of breast
|
0.300 |
Biomarker
|
disease |
BEFREE |
Genetically (siMET) or pharmacologically (INCB28060) targeting MET inhibited both HGF- and pre-OB CM- mediated BC cell migration.
|
26934743 |
2016 |
Malignant neoplasm of breast
|
0.300 |
Biomarker
|
disease |
BEFREE |
Here we demonstrate that treatment of breast cancer cells sensitive to EGFR TKIs with recombinant HGF confers a resistance to EGFR TKIs.
|
22788954 |
2012 |
Malignant neoplasm of breast
|
0.300 |
Biomarker
|
disease |
BEFREE |
Here we show that stimulation of breast cancer cells with the ligand for Met, hepatocyte growth factor, promotes invadopodia formation, and in aggressive gastric tumor cells where Met is amplified, invadopodia formation is dependent on Met activity.
|
22366451 |
2012 |
Malignant neoplasm of breast
|
0.300 |
Biomarker
|
disease |
BEFREE |
Here, we investigated whether HGFK1 is a key regulator of breast cancer bone metastasis.
|
22767217 |
2012 |
Malignant neoplasm of breast
|
0.300 |
Biomarker
|
disease |
BEFREE |
Herein we investigate the regulation of Brk kinase activity and cell migration in response to treatment of keratinocytes (HaCaT cells) and breast cancer cell lines (MDA-MB-231 and T47D cells) with hepatocyte growth factor (HGF) and macrophage stimulating protein (MSP), peptide ligands for Met and Ron receptors, respectively.
|
20687930 |
2010 |
Malignant neoplasm of breast
|
0.300 |
PosttranslationalModification
|
disease |
BEFREE |
In fact, inducing disassociation of MCF-7 and T47D cells in culture by treating with HGF/scatter factor resulted in a loss of CLDN-7 expression within 24 h. Silencing of CLDN-7 expression correlated with promoter hypermethylation as determined by methylation-specific PCR (MSP) and nucleotide sequencing in breast cancer cell lines (3/3), but not in IDCs (0/5).
|
12673207 |
2003 |
Malignant neoplasm of breast
|
0.300 |
Biomarker
|
disease |
BEFREE |
In vitro and in vivo effects of suppressor of cytokine signalling 7 knockdown in breast cancer: the influence on cellular response to hepatocyte growth factor.
|
25162020 |
2014 |
Malignant neoplasm of breast
|
0.300 |
Biomarker
|
disease |
BEFREE |
Inhibition of HGF/SF-induced breast cancer cell motility and invasion by the HGF/SF variant, NK4.
|
10832594 |
2000 |
Malignant neoplasm of breast
|
0.300 |
Biomarker
|
disease |
BEFREE |
Met and its ligand HGF are associated with clinical outcome in breast cancer.
|
27175600 |
2016 |
Malignant neoplasm of breast
|
0.300 |
Biomarker
|
disease |
BEFREE |
Overexpression of LRIG1 destabilizes endogenous Met receptor in breast cancer cells and impairs their ability to respond to HGF.
|
17178829 |
2007 |
Malignant neoplasm of breast
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Reports have demonstrated that HGF/c-Met signalling plays an important part in breast cancer progression and that their expression is linked to poor patient outcome.
|
30314527 |
2018 |