Myocardial Infarction
|
0.100 |
Biomarker
|
disease |
BEFREE |
We examined a coronary artery disease predictive algorithm (CADPA) that includes 9 biomarkers involved in the pathogenesis of atherosclerosis initiated by endothelial damage and repair (hepatocyte growth factor, soluble FAS, Fas ligand, eotaxin, cutaneous T cell-attracting chemokine, monocyte chemotactic protein-3, interleukin-16, hemoglobin A1c, high-density lipoprotein-cholesterol), in addition to age, gender, diabetes, and family history of myocardial infarction that more accurately predicts 5-year risk of ACS to identify the patient population at discordantly high risk.
|
30563615 |
2019 |
Myocardial Infarction
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Both HGF and IGF-1 enhanced the expression of Cx43 and improved induced ventricular arrhythmia in rats with MI.
|
31555539 |
2019 |
Myocardial Infarction
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the anti-inflammatory effects of HGF on myocardial infarction are not defined.
|
29795355 |
2018 |
Myocardial Infarction
|
0.100 |
Biomarker
|
disease |
BEFREE |
Serum hepatocyte growth factor (HGF) is positively associated with poor prognosis of heart failure and myocardial infarction, and it can also predict the risk of ischemic stroke in population.
|
29321335 |
2018 |
Myocardial Infarction
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, recent studies suggested that angiogenic growth factors have pleiotropic effects that may contribute to outcome so we expanded focus of our work to investigate potential mechanisms underlying action of VEGF165, HGF and their combination in MI.
|
29787588 |
2018 |
Myocardial Infarction
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present study evaluated the therapeutic effects of hepatocyte growth factor (HGF) gene-engineered skeletal myoblasts on tissue regeneration and restoration of heart function in a rat MI model.
|
28459804 |
2017 |
Myocardial Infarction
|
0.100 |
Biomarker
|
disease |
BEFREE |
We tested a novel small-molecular hydrogel (SMH) on whether it could provide a scaffold for hepatocyte growth factor (HGF)-modified MSCs and alleviate ventricular remodeling while preserving cardiac function after MI.
|
29158523 |
2017 |
Myocardial Infarction
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Cardiac-specific expression of the hepatocyte growth factor (HGF) under the control of a TnIc promoter confers a heart protective effect after myocardial infarction (MI).
|
24502539 |
2014 |
Myocardial Infarction
|
0.100 |
Biomarker
|
disease |
BEFREE |
The seeded scaffolds were transplanted in rats two weeks after MI (group: PU-HGF-SkM) or the infection solution was intramyocardially injected (group: Inj-HGF-SkM).
|
21899570 |
2012 |
Myocardial Infarction
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, EPO accelerates angiogenesis via the upregulation of systemic levels such as HGF and FGF, and the local expression of VEGF and IGF, in porcine MI.
|
22038108 |
2012 |
Myocardial Infarction
|
0.100 |
Biomarker
|
disease |
BEFREE |
We also analyse the role of HGF/Met in stem cell maintenance and in stem cell therapies for MI.
|
21327916 |
2011 |
Myocardial Infarction
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Mesenchymal stem cells modified with stromal cell-derived factor 1 alpha improve cardiac remodeling via paracrine activation of hepatocyte growth factor in a rat model of myocardial infarction.
|
20016947 |
2010 |
Myocardial Infarction
|
0.100 |
Biomarker
|
disease |
BEFREE |
1.There is growing evidence of the beneficial effects of hepatocyte growth factor (HGF) in myocardial infarction, heart failure and occlusive peripheral arterial disease.
|
19215239 |
2009 |
Myocardial Infarction
|
0.100 |
Biomarker
|
disease |
BEFREE |
Four weeks after MI, rats were randomly divided into a control group (n=11), HGF group (Adenovirus vector carrying human HGF (Ad-HGF)-transfected MSC transplanted into the infarct zone; n=11), G-CSF group (intraperitoneal injection with G-CSF; n=11), and HGF + G-CSF group (Ad-HGF-transfected MSC transplanted into the infarct zone and intraperitoneal injection with G-CSF; n=11).
|
18956268 |
2008 |
Myocardial Infarction
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hepatocyte growth factor (HGF) reportedly exerts beneficial effects on the heart following myocardial infarction and during nonischemic cardiomyopathy, but the precise mechanisms underlying the latter have not been well elucidated.
|
18083897 |
2008 |
Myocardial Infarction
|
0.100 |
Biomarker
|
disease |
LHGDN |
Quantitative MR measurements of regional and global left ventricular function and strain after intramyocardial transfer of VM202 into infarcted swine myocardium.
|
18539758 |
2008 |
Myocardial Infarction
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Four weeks after myocardial infarction (MI), Sprague Dawley rats were randomly divided into saline control group, MSC-GFP group, MSC-HGF group, and MSC-HGF+CsA group.
|
18164961 |
2008 |
Myocardial Infarction
|
0.100 |
Biomarker
|
disease |
BEFREE |
In mice, on day 3 after myocardial infarction (MI), adenovirus encoding human HGF (Ad.CAG-HGF) was injected into the hindlimb muscles (n=13).
|
12695295 |
2003 |
Myocardial Infarction
|
0.100 |
Biomarker
|
disease |
BEFREE |
It indicates a potent therapeutic value of HGF gene transfection for chronic ischemic heart diseases such as myocardial infarction.
|
12683576 |
2003 |
Myocardial Infarction
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our working hypothesis is that HGF may afford myocardial protection from myocardial infarction.
|
11399246 |
2001 |
Myocardial Infarction
|
0.100 |
Biomarker
|
disease |
BEFREE |
Based on these facts, we hypothesized that HGF may prevent restenosis after angioplasty through re endothelialization and myocardial infarction through induction of angiogenesis.
|
11425038 |
2000 |
Myocardial Infarction
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, we studied the pathophysiological role of HGF in a myocardial infarction model.
|
10694824 |
2000 |