HGF, hepatocyte growth factor, 3082

N. diseases: 671; N. variants: 22
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.100 Biomarker disease BEFREE We examined a coronary artery disease predictive algorithm (CADPA) that includes 9 biomarkers involved in the pathogenesis of atherosclerosis initiated by endothelial damage and repair (hepatocyte growth factor, soluble FAS, Fas ligand, eotaxin, cutaneous T cell-attracting chemokine, monocyte chemotactic protein-3, interleukin-16, hemoglobin A1c, high-density lipoprotein-cholesterol), in addition to age, gender, diabetes, and family history of myocardial infarction that more accurately predicts 5-year risk of ACS to identify the patient population at discordantly high risk. 30563615 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.100 AlteredExpression disease BEFREE Both HGF and IGF-1 enhanced the expression of Cx43 and improved induced ventricular arrhythmia in rats with MI. 31555539 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.100 Biomarker disease BEFREE However, the anti-inflammatory effects of HGF on myocardial infarction are not defined. 29795355 2018
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.100 Biomarker disease BEFREE Serum hepatocyte growth factor (HGF) is positively associated with poor prognosis of heart failure and myocardial infarction, and it can also predict the risk of ischemic stroke in population. 29321335 2018
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.100 Biomarker disease BEFREE However, recent studies suggested that angiogenic growth factors have pleiotropic effects that may contribute to outcome so we expanded focus of our work to investigate potential mechanisms underlying action of VEGF165, HGF and their combination in MI. 29787588 2018
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.100 GeneticVariation disease BEFREE The present study evaluated the therapeutic effects of hepatocyte growth factor (HGF) gene-engineered skeletal myoblasts on tissue regeneration and restoration of heart function in a rat MI model. 28459804 2017
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.100 Biomarker disease BEFREE We tested a novel small-molecular hydrogel (SMH) on whether it could provide a scaffold for hepatocyte growth factor (HGF)-modified MSCs and alleviate ventricular remodeling while preserving cardiac function after MI. 29158523 2017
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.100 AlteredExpression disease BEFREE Cardiac-specific expression of the hepatocyte growth factor (HGF) under the control of a TnIc promoter confers a heart protective effect after myocardial infarction (MI). 24502539 2014
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.100 Biomarker disease BEFREE The seeded scaffolds were transplanted in rats two weeks after MI (group: PU-HGF-SkM) or the infection solution was intramyocardially injected (group: Inj-HGF-SkM). 21899570 2012
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.100 AlteredExpression disease BEFREE In conclusion, EPO accelerates angiogenesis via the upregulation of systemic levels such as HGF and FGF, and the local expression of VEGF and IGF, in porcine MI. 22038108 2012
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.100 Biomarker disease BEFREE We also analyse the role of HGF/Met in stem cell maintenance and in stem cell therapies for MI. 21327916 2011
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.100 AlteredExpression disease BEFREE Mesenchymal stem cells modified with stromal cell-derived factor 1 alpha improve cardiac remodeling via paracrine activation of hepatocyte growth factor in a rat model of myocardial infarction. 20016947 2010
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.100 Biomarker disease BEFREE 1.There is growing evidence of the beneficial effects of hepatocyte growth factor (HGF) in myocardial infarction, heart failure and occlusive peripheral arterial disease. 19215239 2009
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.100 Biomarker disease BEFREE Four weeks after MI, rats were randomly divided into a control group (n=11), HGF group (Adenovirus vector carrying human HGF (Ad-HGF)-transfected MSC transplanted into the infarct zone; n=11), G-CSF group (intraperitoneal injection with G-CSF; n=11), and HGF + G-CSF group (Ad-HGF-transfected MSC transplanted into the infarct zone and intraperitoneal injection with G-CSF; n=11). 18956268 2008
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.100 Biomarker disease BEFREE Hepatocyte growth factor (HGF) reportedly exerts beneficial effects on the heart following myocardial infarction and during nonischemic cardiomyopathy, but the precise mechanisms underlying the latter have not been well elucidated. 18083897 2008
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.100 Biomarker disease LHGDN Quantitative MR measurements of regional and global left ventricular function and strain after intramyocardial transfer of VM202 into infarcted swine myocardium. 18539758 2008
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.100 AlteredExpression disease BEFREE Four weeks after myocardial infarction (MI), Sprague Dawley rats were randomly divided into saline control group, MSC-GFP group, MSC-HGF group, and MSC-HGF+CsA group. 18164961 2008
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.100 Biomarker disease BEFREE In mice, on day 3 after myocardial infarction (MI), adenovirus encoding human HGF (Ad.CAG-HGF) was injected into the hindlimb muscles (n=13). 12695295 2003
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.100 Biomarker disease BEFREE It indicates a potent therapeutic value of HGF gene transfection for chronic ischemic heart diseases such as myocardial infarction. 12683576 2003
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.100 Biomarker disease BEFREE Our working hypothesis is that HGF may afford myocardial protection from myocardial infarction. 11399246 2001
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.100 Biomarker disease BEFREE Based on these facts, we hypothesized that HGF may prevent restenosis after angioplasty through re endothelialization and myocardial infarction through induction of angiogenesis. 11425038 2000
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.100 Biomarker disease BEFREE Furthermore, we studied the pathophysiological role of HGF in a myocardial infarction model. 10694824 2000