Pulmonary Fibrosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Moreover, berberine promoted both mRNA and protein levels of HGF and PTEN in colons, but only their protein levels in lungs of PF mice.
|
29408570 |
2018 |
Pulmonary Fibrosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our data further demonstrated that HGF upregulation played an important role in mediating the therapeutic effects of transplanted OSM-preconditioned MSCs in alleviating lung fibrosis in the mice.
|
28297588 |
2017 |
Pulmonary Fibrosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The secretome of induced pluripotent stem cells reduces lung fibrosis in part by hepatocyte growth factor.
|
25384638 |
2014 |
Pulmonary Fibrosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
We conclude that targeted HGF gene transfer specifically to AECII decreases bleomycin-induced lung fibrosis and may therefore represent a novel cell-specific gene transfer technology to treat pulmonary fibrosis.
|
23134111 |
2013 |
Pulmonary Fibrosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results suggest MSC-based HGF gene therapy not only reduces inflammation but also inhibits lung fibrosis.
|
23458413 |
2013 |
Pulmonary Fibrosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Human HGF, which was expressed specifically by alveolar epithelial type II cells after gene transfer, attenuated the bleomycin-induced pulmonary fibrosis in an animal model.
|
22744972 |
2012 |
Pulmonary Fibrosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Administration of HGF protein or ectopic expression of HGF has been demonstrated in animal models of pulmonary fibrosis to induce normal tissue repair and to prevent fibrotic remodeling.
|
21131996 |
2011 |
Pulmonary Fibrosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
By demonstrating an imbalance between HGFA and HAI-1 expression in BAL fluid, our results highlight a defective thrombin-dependent proHGF activation system at the fibrotic phase of bleomycin-induced pulmonary fibrosis.
|
19448157 |
2010 |
Pulmonary Fibrosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Electroporation-mediated in vivo HGF gene transfer using pCikhHGF 7 days after intratracheal bleomycin reduced pulmonary fibrosis as assessed by histology and hydroxyproline determination 14 days after bleomycin compared with controls treated with the same vector not containing the HGF sequence (pCik).
|
17056705 |
2007 |
Pulmonary Fibrosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Hepatocyte growth factor (HGF) protects against lung fibrosis in several animal models.
|
16574935 |
2006 |
Pulmonary Fibrosis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Gene expression of cytokines and growth factors in the lungs after paraquat administration in mice.
|
16324872 |
2006 |
Pulmonary Fibrosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results indicated that gene therapy by the transfection of the human HGF cDNA may thus be a useful therapy for SSc and lung fibrosis involved with SSc.
|
14712301 |
2004 |
Pulmonary Fibrosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
We studied the role of HGF in patients with idiopathic pulmonary fibrosis (IPF) (25 cases), lung fibrosis associated with rheumatoid arthritis (22 cases), and sarcoidosis (39 cases).
|
9115749 |
1997 |