HGF, hepatocyte growth factor, 3082

N. diseases: 671; N. variants: 22
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.400 AlteredExpression disease BEFREE Moreover, berberine promoted both mRNA and protein levels of HGF and PTEN in colons, but only their protein levels in lungs of PF mice. 29408570 2018
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.400 AlteredExpression disease BEFREE Taken together, our data further demonstrated that HGF upregulation played an important role in mediating the therapeutic effects of transplanted OSM-preconditioned MSCs in alleviating lung fibrosis in the mice. 28297588 2017
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.400 Biomarker disease BEFREE The secretome of induced pluripotent stem cells reduces lung fibrosis in part by hepatocyte growth factor. 25384638 2014
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.400 Biomarker disease BEFREE We conclude that targeted HGF gene transfer specifically to AECII decreases bleomycin-induced lung fibrosis and may therefore represent a novel cell-specific gene transfer technology to treat pulmonary fibrosis. 23134111 2013
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.400 Biomarker disease BEFREE These results suggest MSC-based HGF gene therapy not only reduces inflammation but also inhibits lung fibrosis. 23458413 2013
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.400 AlteredExpression disease BEFREE Human HGF, which was expressed specifically by alveolar epithelial type II cells after gene transfer, attenuated the bleomycin-induced pulmonary fibrosis in an animal model. 22744972 2012
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.400 AlteredExpression disease BEFREE Administration of HGF protein or ectopic expression of HGF has been demonstrated in animal models of pulmonary fibrosis to induce normal tissue repair and to prevent fibrotic remodeling. 21131996 2011
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.400 Biomarker disease BEFREE By demonstrating an imbalance between HGFA and HAI-1 expression in BAL fluid, our results highlight a defective thrombin-dependent proHGF activation system at the fibrotic phase of bleomycin-induced pulmonary fibrosis. 19448157 2010
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.400 Biomarker disease BEFREE Electroporation-mediated in vivo HGF gene transfer using pCikhHGF 7 days after intratracheal bleomycin reduced pulmonary fibrosis as assessed by histology and hydroxyproline determination 14 days after bleomycin compared with controls treated with the same vector not containing the HGF sequence (pCik). 17056705 2007
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.400 Biomarker disease BEFREE Hepatocyte growth factor (HGF) protects against lung fibrosis in several animal models. 16574935 2006
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.400 Biomarker disease CTD_human Gene expression of cytokines and growth factors in the lungs after paraquat administration in mice. 16324872 2006
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.400 Biomarker disease BEFREE These results indicated that gene therapy by the transfection of the human HGF cDNA may thus be a useful therapy for SSc and lung fibrosis involved with SSc. 14712301 2004
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.400 Biomarker disease BEFREE We studied the role of HGF in patients with idiopathic pulmonary fibrosis (IPF) (25 cases), lung fibrosis associated with rheumatoid arthritis (22 cases), and sarcoidosis (39 cases). 9115749 1997