|
Fibrosis, Liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together, our study indicated that HGF-transfected MSCs have therapeutic effects on DMN-induced liver fibrosis in rats.
|
31452434 |
2019 |
|
Fibrosis, Liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In vivo, the combination therapy reduced liver fibrosis (associated with increased matrix metalloproteinases expression), increased hepatocyte proliferation (associated with increased hepatocyte growth factor, vascular endothelial growth factor, and oncostatin M in the liver), and reduced blood levels of liver enzymes, more effectively than MSCs or id-BMMs monotherapy.
|
30394698 |
2019 |
|
Fibrosis, Liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
Outcome variables were: a) liver fibrosis (Metavir score) [fibrosis stage (F0, F1, F2, F3 and F4) and advanced fibrosis and cirrhosis (F ≥ 3 and F4, respectively)]; b) non-invasive indexes [FIB-4, APRI, and their cut-offs (FIB-4 ≥ 3.25 and APRI≥1.5)]; c) inflammation-related biomarkers (leptin, HGF, NGF, sFasL, sFas, MIF, HA, Ang-2, TIMP1, MMP1 and MMP2).
|
30336268 |
2019 |
|
Fibrosis, Liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Taken together, we first reported on the sequence of HGF from guinea pig and determined the anti-fibrotic activity of gmNK1 in hepatic fibrosis, which will be helpful for investigations into the biological roles of gHGF in this important animal model.
|
28837849 |
2018 |
|
Fibrosis, Liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
To investigate the modulating effects of date fruits on pro- and anti-apoptotic markers, cytochrome P450 2E1 (CYP2E1) and hepatocyte growth factor (HGF) in liver fibrosis.
|
27960551 |
2017 |
|
Fibrosis, Liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
Transplantation of MSCs Overexpressing HGF into a Rat Model of Liver Fibrosis.
|
26194009 |
2016 |
|
Fibrosis, Liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Increased miR-16 expression induced by hepatitis C virus infection promotes liver fibrosis through downregulation of hepatocyte growth factor and Smad7.
|
26071245 |
2015 |
|
Fibrosis, Liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
HGF expressed by hHGF-HUCB-MSCs exerted a stimulatory effect on hepatocyte proliferation in vitro. hHGF-HUCB-MSCs were transplanted to investigate the therapeutic effects of these cells on carbon tetrachloride (CCL4)-induced liver fibrosis in a rat model.
|
24115681 |
2014 |
|
Fibrosis, Liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, liver function was improved in animals receiving MSCs/HGF, indicating that MSC/HGF therapy resulted not only in reduction of liver fibrosis but also in improvement of hepatocyte function.
|
25145391 |
2014 |
|
Fibrosis, Liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
HGF-overexpressing ADSCs ameliorated radiation- induced liver fibrosis through down regulation of α-SMA and fibronectin.
|
25501583 |
2014 |
|
Fibrosis, Liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study evaluated the role of ASH1 and EZH2 in two mechanistically different therapeutic modalities, HGF and mMMP-9 gene transfer in CCl4 induced rat liver fibrosis.
|
25380300 |
2014 |
|
Fibrosis, Liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, we demonstrate that hepatocyte growth factor (HGF), an antifibrotic factor in the process of pulmonary, renal and liver fibrosis, is a negative regulator of cardiac fibroblast transformation in response to transforming growth factor‑β1 (TGF‑β1).
|
24840640 |
2014 |
|
Fibrosis, Liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Hepatic stellate cell-targeted delivery of hepatocyte growth factor transgene via bile duct infusion enhances its expression at fibrotic foci to regress dimethylnitrosamine-induced liver fibrosis.
|
23527815 |
2013 |
|
Fibrosis, Liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
We found that HGF/MSCs significantly inhibited the formation of liver fibrosis in rats undergoing SFSLT, while MSCs and HGF had synergistic effects in the process.
|
20025519 |
2010 |
|
Fibrosis, Liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Cirrhotic rats treated with rSVIGF-I had reduced serum bilirubin, transaminases and liver fibrosis scores and increased hepatic expression of hepatocyte growth factor and STAT3alpha as compared to cirrhotic animals.
|
17024107 |
2007 |
|
Fibrosis, Liver
|
0.400 |
Therapeutic
|
disease |
CTD_human |
Effects of hepatotrophic factors on the liver after portacaval shunt in rats with portal hypertension.
|
17097021 |
2006 |
|
Fibrosis, Liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here we evaluated the therapeutic efficacy of hepatocyte growth factor (HGF) on liver fibrosis induced by bile duct ligation (BDL) and investigated potential mechanisms.
|
16651617 |
2006 |
|
Fibrosis, Liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results suggest that the combination of HGF and TbetaTR gene therapy may increase the possibility of hepatectomy in a cirrhotic liver by improving fibrosis, hepatic function, and hepatocyte regeneration.
|
16627068 |
2006 |
|
Fibrosis, Liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Hepatocyte growth factor and c-Met expression in rat and human liver fibrosis.
|
15287857 |
2004 |