|
Limb ischemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present study, we evaluated the therapeutic potential of gene-modified adipose-derived stromal cells (ADSC) that overexpress hepatocyte growth factor (HGF) in a mice hind limb ischemia model.
|
31238604 |
2019 |
|
Limb ischemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
A Randomized, Double-Blind, Placebo-Controlled Phase II Study of Hepatocyte Growth Factor in the Treatment of Critical Limb Ischemia.
|
31805256 |
2019 |
|
Limb ischemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The current advances of clinical trials of plasmid and adenovirus HGF in the treatment of critical limb ischemia and coronary heart disease in China are introduced.
|
29409352 |
2018 |
|
Limb ischemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Gram-scale production of plasmid pUDK-HGF with current good manufacturing practices for gene therapy of critical limb ischemia.
|
26853514 |
2016 |
|
Limb ischemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Clinical Safety and Preliminary Efficacy of Plasmid pUDK-HGF Expressing Human Hepatocyte Growth Factor (HGF) in Patients with Critical Limb Ischemia.
|
26122834 |
2015 |
|
Limb ischemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recently, two multicenter, double-blind, placebo-controlled clinical trials in Japan (Phase III) and the USA (Phase II) showed the benefits of hepatocyte growth factor (HGF) gene therapy for CLI patients.
|
25633211 |
2015 |
|
Limb ischemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Biochemical and immunomorphological evaluation of hepatocyte growth factor and c-Met pathway in patients with critical limb ischemia.
|
24947080 |
2014 |
|
Limb ischemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In vivo tests of VEGF165 and HGF genes co-transfer were conceived in mouse model of hind limb ischemia.
|
22719942 |
2012 |
|
Limb ischemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study investigated the efficacy and safety of intramuscular injection of naked plasmid DNA encoding the human hepatocyte growth factor gene in Japanese patients with Buerger's disease and critical limb ischemia.
|
21427651 |
2011 |
|
Limb ischemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Safety of a non-viral plasmid-encoding dual isoforms of hepatocyte growth factor in critical limb ischemia patients: a phase I study.
|
21430785 |
2011 |
|
Limb ischemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
A phase I clinical study of naked DNA expressing two isoforms of hepatocyte growth factor to treat patients with critical limb ischemia.
|
22015632 |
2011 |
|
Limb ischemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Phase I/IIa clinical trial of therapeutic angiogenesis using hepatocyte growth factor gene transfer to treat critical limb ischemia.
|
21183732 |
2011 |
|
Limb ischemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Safety of vascular endothelial and hepatocyte growth factor gene therapy in patients with critical limb ischemia.
|
21675956 |
2011 |
|
Limb ischemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The experimental study using a rat model of hind limb ischemia showed usefulness of 99mTc-MIBI scintigraphy to evaluate the angiogenic effect of HGF plasmid treatment.
|
21633313 |
2011 |
|
Limb ischemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Randomized, double-blind, placebo-controlled clinical trial of hepatocyte growth factor plasmid for critical limb ischemia.
|
20393508 |
2010 |
|
Limb ischemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Naked DNA expressing two isoforms of hepatocyte growth factor induces collateral artery augmentation in a rabbit model of limb ischemia.
|
20668482 |
2010 |
|
Limb ischemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Results of a double-blind, placebo-controlled study to assess the safety of intramuscular injection of hepatocyte growth factor plasmid to improve limb perfusion in patients with critical limb ischemia.
|
18559703 |
2008 |
|
Limb ischemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Using murine limb ischemia as a tumor-free assay system, we demonstrated that p70S6K inhibitor rapamycin (RAPA) targets mesenchymal cells to shut down the sustained expression of vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF), via silencing of the PDGFRalpha-p70S6K pathway.
|
15059936 |
2004 |
|
Limb ischemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we report that angiogenic growth factors, including HGF, were upregulated in a murine model of critical limb ischemia in vivo, a finding that was in conflict with previous in vitro data.
|
12433837 |
2002 |
|
Limb ischemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat diabetic hind limb ischemia model: molecular mechanisms of delayed angiogenesis in diabetes.
|
11696476 |
2001 |
|
Limb ischemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus in view of the decreased endogenous vascular HGF, rhHGF (500 micrograms/animal) was intra-arterially administered through the internal iliac artery of rabbits in which the femoral artery was excised to induce unilateral hind limb ischemia, to evaluate the angiogenic activity of HGF, which could potentially have a beneficial effect in hypoxia.
|
10373220 |
1999 |