These results indicate that CD209 has a crucial role in dengue pathogenesis, which discriminates between severe dengue fever and dengue hemorrhagic fever.
We demonstrated that the TT genotype of CLEC5A SNP (rs1285933 C>T) is associated with dengue severity (OR=2.25; p=0.03) and that GG genotype of -336G>A DCSIGN (CD209) SNP is associated with protection to severe dengue (OR=0.12; p=0.04).
A common CD209-336G/A (rs4804803) polymorphism in DC-SIGN may affect severity of dengue virus infection (DEN) and incidence of dengue fever (DF) or the more severe dengue hemorrhagic fever (DHF).
<i>Conclusions</i>: Dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (<i>DC-SIGN</i>) promoter-336G/A (<i>rs4804803</i>) polymorphism is association with severe dengue, and it acts in different directions for Asians and South-central Americans.